Inflammasome Activation in Chronic Glomerular Diseases.

abstract：:Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...

journal_title：Current drug targets

authors： Kulkarni S,Ghosh SP,Hauer-Jensen M,Kumar KS

更新日期：2010-11-01 00:00:00

abstract：:The most widely used mouse models for atherosclerosis are LDL receptor knockout (KO) mice and apolipoprotein E (apoE) KO mice fed standard chow diets or lipid-supplemented diets. Unfortunately, these do not usually exhibit myocardial infarction or other features of human cardiovascular disease such as occlusive corona...

journal_title：Current drug targets

authors： Braun A,Rigotti A,Trigatti BL

更新日期：2008-03-01 00:00:00

abstract：:Infiltrating inflammatory cells into the kidney mediate the initiation and progression of damage by direct cytotoxicity, the secretion of soluble factors such as cytokines and proteases, or by the subsequent induction of further immune response. Before leukocytes can exert their effects on renal damage or repair, they...

journal_title：Current drug targets

authors： Panzer U,Steinmetz OM,Stahl RA,Wolf G

更新日期：2006-01-01 00:00:00

abstract：:Multi-target drugs against particular multiple targets get better protection, resistance profiles and curative influence by cooperative rules of a key beneficial target with resistance behavior and compensatory elements. Computational techniques can assist us in the efforts to design novel drugs (ligands) with a prefe...

journal_title：Current drug targets

authors： Abdolmaleki A,Ghasemi JB,Ghasemi F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...

journal_title：Current drug targets

authors： Kwon S,Wang AH,Sadowski CA,Yuksel N,Doschak MR

更新日期：2018-01-01 00:00:00

abstract：:Vaccines have been described as "weapons of mass protection". The eradication of many diseases is testament to their utility and effectiveness. Nevertheless, many vaccine preventable diseases remain prevalent because of political and economic barriers. Additionally, the effects of immaturity and old age, therapies tha...

journal_title：Current drug targets

authors： Eisen DP,Liley HG,Minchinton RM

更新日期：2004-01-01 00:00:00

abstract：:The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

journal_title：Current drug targets

authors： De Gaudio AR,Rinaldi S

更新日期：2005-11-01 00:00:00

abstract：:Nowadays, natural compounds of plant origin with anticancer effects have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway that may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve artic...

journal_title：Current drug targets

authors： Forouzanfar F,Mousavi SH

更新日期：2020-01-01 00:00:00

abstract：:It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheuma...

journal_title：Current drug targets

authors： Morimoto J,Kon S,Matsui Y,Uede T

更新日期：2010-04-01 00:00:00

abstract：:Recently, a significant number of breast cancer (BC) patients have been diagnosed at an early stage. It is therefore critical to accurately predict the risk of recurrence and distant metastasis for better management of BC in this setting. Clinicopathologic patterns, particularly lymph node status, tumor size, and horm...

journal_title：Current drug targets

authors： Gouri A,Benarba B,Dekaken A,Aoures H,Benharkat S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Recently, there are scientific attempts to discover new drugs in the biotechnology industry in order to treat various diseases including atherosclerosis. OBJECTIVE:The main objective of the present review was to highlight the cellular, molecular biology and inflammatory process related to the atheromatous p...

journal_title：Current drug targets

authors： Thent ZC,Chakraborty C,Mahakkanukrauh P,Nik Ritza Kosai Nik Mahmood N,Rajan R,Das S

更新日期：2017-01-01 00:00:00

abstract：:The liver is essential for the control of glucose and lipid metabolism. Excessive accumulation of fat in the liver disturbs its function and leads to the development of fatty liver diseases. The nonalcoholic fatty liver disease (NAFLD) is a common type of fatty liver disease found in patients who have not consumed sig...

journal_title：Current drug targets

authors： Chen G

更新日期：2015-01-01 00:00:00

abstract：:Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the overproduction of membrane transport proteins that are capable to pump chemotherapeutics, antibiotics, detergents, dyes and organic solvents out of the cell. In Gram-negat...

journal_title：Current drug targets

authors： Seeger MA,Diederichs K,Eicher T,Brandstätter L,Schiefner A,Verrey F,Pos KM

更新日期：2008-09-01 00:00:00

abstract：:Virtual screening for active compounds has become an essential step within the drug development pipeline. The computer based prediction of compound binding modes is one of the most time and cost efficient methods for screening ligand libraries and enrich results of potential drugs. Here we present an overview about cu...

journal_title：Current drug targets

authors： Krüger J,Thiel P,Merelli I,Grunzke R,Gesing S

更新日期：2016-01-01 00:00:00

abstract：:The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...

journal_title：Current drug targets

authors： Chiozzini C,Toschi E

更新日期：2016-01-01 00:00:00

abstract：:Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific frater...

journal_title：Current drug targets

authors： Varghese R,Dalvi YB

更新日期：2020-12-30 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...

journal_title：Current drug targets

authors： Simonsson B,Hjorth-Hansen H,Bjerrum OW,Porkka K

更新日期：2011-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (referred here as pancreatic cancer) is a lethal disease with the worst prognosis among all solid tumors. Surgical resection represents the only hope for cure but it is possible only in patients that present with local disease (about 20% of cases). Whether dismal prognosis of pancreati...

journal_title：Current drug targets

authors： Corbo V,Tortora G,Scarpa A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds...

journal_title：Current drug targets

authors： Farhat SM,Ahmed T

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...

journal_title：Current drug targets

authors： Dauri M,Faria S,Gatti A,Celidonio L,Carpenedo R,Sabato AF

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...

journal_title：Current drug targets

authors： Virgili G,Novielli N,Menchini F,Murro V,Giacomelli G

更新日期：2011-02-01 00:00:00

abstract：:The last decade has witnessed the introduction of a large number of novel, molecularly targeted agents into the therapeutic armamentarium against diverse forms of cancer, including leukemia. Such agents include signal transduction, cell cycle, histone deacetylase, Hsp90, proteasome, and Bcl-2 family member inhibitors,...

journal_title：Current drug targets

authors： Grant S,Dent P

更新日期：2007-06-01 00:00:00

abstract：:Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...

journal_title：Current drug targets

authors： Fisher KW,Montironi R,Lopez Beltran A,Moch H,Wang L,Scarpelli M,Williamson SR,Koch MO,Cheng L

更新日期：2015-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:There exists an immediate need to develop novel medications for the treatment of mood disorders such as bipolar disorder and depression. Initial interest in glycogen synthase kinase-3 (GSK-3) as a target for the treatment of mood disorders arose from the finding that the mood stabilizing drug lithium directly inhibite...

journal_title：Current drug targets

authors： Gould TD,Picchini AM,Einat H,Manji HK

更新日期：2006-11-01 00:00:00

abstract：:Osteoporosis causes bone loss, and makes bone to susceptible to fracture. The main cause of osteoporosis is estrogen deficiency. Estrogen, calcitonin, calcium, vitamin D and antioxidants can be used to prevent osteoporosis. For the treatment of osteoporosis, the potential biological activities of traditional medicines...

journal_title：Current drug targets

authors： Süntar I,Akkol EK

更新日期：2013-12-01 00:00:00

abstract：:RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four units is relatively low ...

journal_title：Current drug targets

authors： Cairns MJ,Saravolac EG,Sun LQ

更新日期：2002-06-01 00:00:00

abstract：:Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

journal_title：Current drug targets

authors： Rutkowska A,Dev KK,Sailer AW

更新日期：2016-01-01 00:00:00

abstract：:5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. The pathophysiological effects of LTs can be modulated by the selective inhibition o...

journal_title：Current drug targets

authors： Anwar Y,Sabir JS,Qureshi MI,Saini KS

更新日期：2014-04-01 00:00:00

abstract：:Patients with heart failure undergoing non-cardiac surgery still have an unacceptably high morbidity and mortality. Compromised myocardial physiologic reserves in combination with extensive surgery and anesthesia appear to play a crucial role in determining high perioperative morbidity and mortality. Nevertheless, sev...

journal_title：Current drug targets

authors： Morelli A,Ertmer C,Pietropaoli P,Westphal M

更新日期：2009-09-01 00:00:00