Abstract:
BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds to α7 nicotinic acetylcholine receptors (nAChRs) with very high affinity. This discovery has led to extensive exploration of the possible outcomes of this binding, ranging from the subcellular signaling pathways to its effects on behavioral and cognitive functions. Intriguingly, there are conflicting reports about the effects of this Aβ and α7 nAChR interaction; a few studies report a neuroprotective role of this interaction while others claim that it is neurotoxic. CONCLUSION:This review focuses on the neurotoxic and neuroprotective effects of Aβ and α7 nAChR interaction and its implications on different cell signaling pathways and other physiological functions. Moreover, the implications this interaction might have on Alzheimer's disease therapy are also discussed.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Farhat SM,Ahmed Tdoi
10.2174/1389450117666161005145143subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1537-1544issue
13eissn
1389-4501issn
1873-5592pii
CDT-EPUB-78766journal_volume
18pub_type
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