Abstract:
:NMDA receptors are a subclass of excitatory, ionotropic L-glutamate neurotransmitter receptors. They are.heteromeric, integral membrane proteins being formed by the assembly of the obligatory NR1 subunit together with modulatory NR2 subunits of which four different types, NR2A-NR2D, have been described. This results in a heterogenous population of receptor proteins with distinct pharmacological and biophysical properties thus yielding potential for the development of NMDA receptor subtype-selective therapeutic agents. Anti-NMDA receptor subunit antibodies have been generated and used in immunoprecipitation or immunoaffinity purification studies to determine the in vivo subunit complements of NMDA receptors. This article summarizes knowledge on the subunit compositions of NMDA receptors based on these approaches together with the current status of NMDA receptor subunit stoichiometry and hence quaternary structure. of native NMDA receptors.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Stephenson FAdoi
10.2174/1389450013348461keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
233-9issue
3eissn
1389-4501issn
1873-5592journal_volume
2pub_type
杂志文章,评审abstract::Vaccines have been described as "weapons of mass protection". The eradication of many diseases is testament to their utility and effectiveness. Nevertheless, many vaccine preventable diseases remain prevalent because of political and economic barriers. Additionally, the effects of immaturity and old age, therapies tha...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 历史文章,杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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journal_title:Current drug targets
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更新日期:2013-07-01 00:00:00
abstract::Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biolo...
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008786949379
更新日期:2008-12-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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