Three-Dimensional Manufactured Supports for Breast Cancer Stem Cell Population Characterization.

abstract：:Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...

journal_title：Current drug targets

authors： Tan JX,Lv H,Wang F,Dao FY,Chen W,Ding H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Endometriosis (EMS) is a gynecological disease defined by the translocation and growth of endometrial tissue in other tissues or organs outside the uterus. Its clinical manifestations are dysmenorrhea, irregular menstruation, and even infertility. Although EMS is a benign disease, it has the characteristics ...

journal_title：Current drug targets

authors： Ding L,Yang L,Ren C,Zhang H,Lu J,Wang S,Wu Z,Yang Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...

journal_title：Current drug targets

authors： Kwon S,Wang AH,Sadowski CA,Yuksel N,Doschak MR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Different clinical studies have given inconsistent results on whether the use of antipsychotics increases the risk of thromboembolism. In this paper, we reviewed all relevant literature to provide suggestions for clinical diagnosis and treatment. METHODS:PubMed, Web of Science, EMBASE, MEDLINE, Cochrane and...

journal_title：Current drug targets

authors： Dai L,Zuo Q,Chen F,Chen L,Shen Y

更新日期：2020-01-01 00:00:00

abstract：:Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

journal_title：Current drug targets

authors： Rutkowska A,Dev KK,Sailer AW

更新日期：2016-01-01 00:00:00

abstract：:Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. These databases are devoted to a wide spectrum of scientific fields. Here we are concerned with databases related to protein-drug interactions. More specifically, databases...

journal_title：Current drug targets

authors： Timmers LF,Pauli I,Caceres RA,de Azevedo WF Jr

更新日期：2008-12-01 00:00:00

abstract：:The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...

journal_title：Current drug targets

authors： Sartiani L,Romanelli MN,Mugelli A,Cerbai E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The Coronavirus Disease 2019 (COVID-19) is becoming the major health issue in recent human history with thousands of deaths and millions of cases worldwide. Newer research and old experience with other corona-viruses highlighted a probable underlying mechanism of disturbance of the renin-angiotensin system (...

journal_title：Current drug targets

authors： Vieira C,Nery L,Martins L,Jabour L,Dias R,Simões E Silva AC

更新日期：2020-10-20 00:00:00

abstract：:The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...

journal_title：Current drug targets

authors： Epifano F,Curini M,Marcotullio MC,Genovese S

更新日期：2011-12-01 00:00:00

abstract：:Recent progress in molecular biology has provided application of gene transfer methods in arthritis. Two clinical trails using ex vivo retrovirus mediated delivery of interleukin -1 receptor antagonist gene for rheumatoid arthritis has begun in USA and Germany. However, there are still many issues to be elucidated; on...

journal_title：Current drug targets

authors： Tomita T,Hashimoto H,Yoshikawa H

更新日期：2003-11-01 00:00:00

abstract：:One approach to identify new drugs with antimicrobial activities is to screen large libraries of molecules directly for their capacity to block the growth of bacterial or fungal monocultures. A more relevant way to assess both a product's efficacy and its potential cytotoxicity is undoubtedly to use an in vivo infecti...

journal_title：Current drug targets

authors： Squiban B,Kurz CL

更新日期：2011-06-01 00:00:00

abstract：:Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to ov...

journal_title：Current drug targets

authors： Guiard BP,Lanfumey L,Gardier AM

更新日期：2006-02-01 00:00:00

abstract：:It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheuma...

journal_title：Current drug targets

authors： Morimoto J,Kon S,Matsui Y,Uede T

更新日期：2010-04-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) metabolizes heme to generate carbon monoxide (CO), biliverdin, and iron. Biliverdin is subsequently metabolized to bilirubin by biliverdin reductase. HO-1 has recently emerged as a promising therapeutic target in the treatment of vascular disease. Pharmacological induction or gene transfer of H...

journal_title：Current drug targets

authors： Durante W

更新日期：2010-12-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a major type of ionotropic glutamate receptor. Many studies have shown that NMDA receptors play a pivotal role in the central nervous system (CNS) under both physiological and pathological conditions. The functional diversity of NMDA receptors can be mainly attributed to the...

journal_title：Current drug targets

authors： Li ST,Ju JG

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE:Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhancing the efficacy and improving the safet...

journal_title：Current drug targets

authors： Barkat MA,Harshita,Ahmad J,Khan MA,Beg S,Ahmad FJ

更新日期：2018-01-01 00:00:00

abstract：:Cell proliferation, differentiation, and survival are regulated by a number of extracellular hormones, growth factors, and cytokines in complex organisms. The transduction of the signals by these factors from the outside to the nucleus often requires the presence of small intracellular proteins (i.e. ras and other sma...

journal_title：Current drug targets

authors： Caraglia M,Budillon A,Tagliaferri P,Marra M,Abbruzzese A,Caponigro F

更新日期：2005-05-01 00:00:00

abstract：:Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivit...

journal_title：Current drug targets

authors： Walsh M,Fritz S,Hake D,Son M,Greve S,Jbara M,Chitta S,Fritz B,Miller A,Bader MK,McCollester J,Binz S,Liew-Spilger A,Thomas S,Crepinsek A,Shariff F,Ploplis V,Castellino FJ

更新日期：2016-01-01 00:00:00

abstract：:Epithelia are the layers of cells that form barriers between external milieu and underlying tissues and thus, are important components of most organs of the body. Epithelial layers of organs, such as the lung, are exposed to various challenges resulting in frequent injury. Epithelial wound healing represents an import...

journal_title：Current drug targets

authors： Allahverdian S,Patchell BJ,Dorscheid DR

更新日期：2006-05-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...

journal_title：Current drug targets

authors： Simonsson B,Hjorth-Hansen H,Bjerrum OW,Porkka K

更新日期：2011-03-01 00:00:00

abstract：:Galectin-1 (Gal1) was the first identified member of the galectin family of beta-galactosidase-binding proteins. Gal1 has important roles in processes fundamental to growth and survival of an organism, including cell adhesion, cell proliferation and apoptosis, and is expressed in many tissues, including the nervous sy...

journal_title：Current drug targets

authors： Gaudet AD,Steeves JD,Tetzlaff W,Ramer MS

更新日期：2005-06-01 00:00:00

abstract：:Atherosclerosis is now widely appreciated to represent a chronic inflammatory reaction of the vascular wall in response to dyslipidemia and endothelial distress involving the inflammatory recruitment of leukocytes and the activation of resident vascular cells. The proliferative response of smooth muscle cells critical...

journal_title：Current drug targets

authors： Weber C,Schober A,Zernecke A

更新日期：2010-08-01 00:00:00

abstract：:Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...

journal_title：Current drug targets

authors： Mohamed N,Muhammad N,Shuid AN,Soelaiman IN

更新日期：2018-01-01 00:00:00

abstract：:Adipose tissue plays an active role in energy balance because it is not only a lipid storing and mobilizing tissue but consists of functionally specialized tissues able to produce heat (in brown adipose tissue) and to produce or release a vast number of so called adipokines or adipocytokines. These consist of polypept...

journal_title：Current drug targets

authors： Klaus S

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain lar...

journal_title：Current drug targets

authors： Song X,Luo X,Gao Q,Wang Y,Gao Q,Long W

更新日期：2017-01-01 00:00:00

abstract：:Epigenetic modifications ensure the maintenance of normal cellular functions, and their dysregulation is frequently found in many disease states, including cancer. Nowadays, the most studied epigenetic dysregulation associated with tumorigenesis, cancer progression and metastasis refers to the variations in DNA methyl...

journal_title：Current drug targets

authors： Lin SQ,Li X

更新日期：2020-01-01 00:00:00

abstract：:Disorders of emotion regulation such as anxiety disorders and depression are common and yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the regulation of emotion. Mice with targeted deletion of genes encoding mediators of the serotonergic transmission have proven to be a powerful to...

journal_title：Current drug targets

authors： Araragi N,Lesch KP

更新日期：2013-05-01 00:00:00

abstract：:The last 15 years have witnessed a resurgence of the role of surgical options for prevention of ischemic stroke. The landmark randomized trials including NASCET and ECST were published and explored the role of carotid endarterectomy in this regard. Patients with high grade stenosis of the internal carotid artery (> or...

journal_title：Current drug targets

authors： Rajamani K,Chaturvedi S

更新日期：2007-07-01 00:00:00

abstract：:Alzheimer's disease (AD) has become linked to inflammation and metal biology. Metals (copper, zinc and iron) and inflammatory cytokines are significant factors that increase the onset of sporadic late onset forms of the dementia. The genetic discovery that alleles in the hemochromatosis gene accelerate the onset of di...

journal_title：Current drug targets

authors： Rogers JT,Lahiri DK

更新日期：2004-08-01 00:00:00

abstract：:Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...

journal_title：Current drug targets

authors： Oates PJ

更新日期：2008-01-01 00:00:00