Abstract:
:It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheumatoid arthritis (RA) is also a chronic inflammatory disease characterized by synovial inflammation in which several inflammatory cytokines are involved. On the other hand, Osteopontin (Opn) is a pleiotropic cytokine expressed by activated T cells, dendritic cells (DCs) and macrophages and its expression is up-regulated during inflammation. Secreted form of Opn (s-Opn), which is modified by phosphorylation, glycosylation and proteolytic cleavage with thrombin, has activities as a T helper type 1 (Th1) cytokine and as a chemoattractant for many types of cells through integrin receptors and CD44. Recently, it has been uncovered that intracellular form of Opn (i-Opn) is a critical regulator for Toll like receptor-9 (TLR-9), TLR-7-dependent interferon-alpha (IFN-alpha) expression by plasmacytoid DCs and Th17 development. In this review, we have summarized recent progress in understanding of Opn's role in variety of inflammatory disorders.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Morimoto J,Kon S,Matsui Y,Uede Tdoi
10.2174/138945010790980321subject
Has Abstractpub_date
2010-04-01 00:00:00pages
494-505issue
4eissn
1389-4501issn
1873-5592pii
CDT-ms48journal_volume
11pub_type
杂志文章,评审abstract::Stroke is one of the leading causes of death and disability worldwide. Because stroke is a multifactorial disease with a short therapeutic window many clinical stroke trials have failed and the only currently approved therapy is thrombolysis. MicroRNAs (miRNA) are endogenously expressed noncoding short single-stranded...
journal_title:Current drug targets
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doi:10.2174/138945013804806424
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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更新日期:2016-01-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033491000
更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.2174/138945007780058933
更新日期:2007-03-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011794751492
更新日期:2011-04-01 00:00:00
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abstract::Breast cancer is the most common cancer in women in the United States, with African-American (AA) women showing significantly higher rates than Caucasian-American (CA) women do. The reason for this racial disparity remains unknown, and factors that might be responsible for the differences in incidence and mortality ha...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Current drug targets
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journal_title:Current drug targets
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更新日期:2014-01-01 00:00:00
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journal_title:Current drug targets
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更新日期:2017-01-01 00:00:00
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journal_title:Current drug targets
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更新日期:2017-01-01 00:00:00