Gene therapy for arthritis.

abstract：BACKGROUND:It becomes increasingly evident that the SARS-CoV-2 infection is not limited to the respiratory system. In addition to being a target of the virus, the kidney also seems to have a substantial influence on the outcomes of the disease. METHODS:Data was obtained by a comprehensive and non-systematic search in ...

journal_title：Current drug targets

authors： Bitencourt L,Pedrosa AL,de Brito SBCS,Fróes ACF,de Carvalho ST,Fonseca GG,Ferreira GC,Fradico PF,Simões E Silva AC

更新日期：2021-01-01 00:00:00

abstract：:Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...

journal_title：Current drug targets

authors： Mohamed RMP,Kumar J,Yap E,Mohamed IN,Sidi H,Adam RL,Das S

更新日期：2019-01-01 00:00:00

abstract：:Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. surplus energy intake over expenditure, is at the core f...

journal_title：Current drug targets

authors： Liu Z,Yang B

更新日期：2019-01-01 00:00:00

abstract：:Adenocarcinoma of the prostate is the most common type of cancer, excluding skin cancer, and the second leading cause of cancer death in adult men in the United States. The lifetime risk for developing symptomatic prostate cancer is one in five for an American man. A pivotal step in carcinogenesis is a shift in the ba...

journal_title：Current drug targets

authors： Bello-DeOcampo D,Tindall DJ

更新日期：2003-04-01 00:00:00

abstract：:Viral myocarditis is a cardiac disease caused by Group B Coxsackie virus of Enterovirus genus in the Picorna viridae family. It causes heart failure in children, young and adults. Ten Percent (10%) of acute heart failure and 12% of sudden deaths in young and adults who are less than 40 years is due to this viral myoca...

journal_title：Current drug targets

authors： Daba TM,Zhao Y,Pan Z

更新日期：2019-01-01 00:00:00

abstract：:Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. These databases are devoted to a wide spectrum of scientific fields. Here we are concerned with databases related to protein-drug interactions. More specifically, databases...

journal_title：Current drug targets

authors： Timmers LF,Pauli I,Caceres RA,de Azevedo WF Jr

更新日期：2008-12-01 00:00:00

abstract：:The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...

journal_title：Current drug targets

authors： Perrotti D,Silvestri G,Stramucci L,Yu J,Trotta R

更新日期：2017-01-01 00:00:00

abstract：:Virtual screening for active compounds has become an essential step within the drug development pipeline. The computer based prediction of compound binding modes is one of the most time and cost efficient methods for screening ligand libraries and enrich results of potential drugs. Here we present an overview about cu...

journal_title：Current drug targets

authors： Krüger J,Thiel P,Merelli I,Grunzke R,Gesing S

更新日期：2016-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. Existing therapies have shown to be insufficient and novel strategies are urgently necessary. New advances in understanding the disease a...

journal_title：Current drug targets

authors： Nascimento AV,Bousbaa H,Ferreira D,Sarmento B

更新日期：2015-01-01 00:00:00

abstract：:Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific frater...

journal_title：Current drug targets

authors： Varghese R,Dalvi YB

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension. OBJECTIVE:Nanotechnology in drug delivery has been evid...

journal_title：Current drug targets

authors： Jain A,Kumari R,Tiwari A,Verma A,Tripathi A,Shrivastava A,Jain SK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic ...

journal_title：Current drug targets

authors： Kugo H,Moriyama T,Zaima N

更新日期：2018-01-01 00:00:00

abstract：:The overuse of antibiotics which exerts the selective pressure for bacterial pathogens has facilitated the spread of antibiotics' resistance. Metallo-β-lactamases (MβLs) are zinc enzymes produced by an increasing number of bacterial pathogens. They can readily cleave carbapenems and most other β-lactams that are mains...

journal_title：Current drug targets

authors： Guo Z,Ma S

更新日期：2014-01-01 00:00:00

abstract：:Autophagy is a process the primary role of which is to clear up damaged cellular components such as long-lived proteins and organelles, thus participating in the conservation of different cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism with suppression of bone format...

journal_title：Current drug targets

authors： Wang T,He H,Liu S,Jia C,Fan Z,Zhong C,Yu J,Liu H,He C

更新日期：2019-01-01 00:00:00

abstract：:Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...

journal_title：Current drug targets

authors： Fisher KW,Montironi R,Lopez Beltran A,Moch H,Wang L,Scarpelli M,Williamson SR,Koch MO,Cheng L

更新日期：2015-01-01 00:00:00

abstract：:Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biolo...

journal_title：Current drug targets

authors： Gulcan HO,Orhan IE

更新日期：2021-01-20 00:00:00

abstract：:Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...

journal_title：Current drug targets

authors： Improta G,Broccardo M

更新日期：2006-08-01 00:00:00

abstract：:Over the past years, there was an explosion in the knowledge of the protein target and molecular mechanism associated with various disease types and in the new research of drugs of natural origin. The key idea is to evaluate bioactive natural products interacting with protein domains of different genetic origin but st...

journal_title：Current drug targets

authors： Braca A,Dal Piaz F,Marzocco S,Autore G,Vassallo A,De Tommasi N

更新日期：2011-03-01 00:00:00

abstract：:Candida species, in particular C. albicans, represent a major threat to immunocompromised patients. Able to exist as a commensal on mucosal surfaces of healthy individuals, these opportunistic fungi frequently cause superficial infections of mucosae and skin. Furthermore, in hospital settings, Candida species may caus...

journal_title：Current drug targets

authors： Mavor AL,Thewes S,Hube B

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the ...

journal_title：Current drug targets

authors： Shrivastava S,Gupta A,Kaur CD

更新日期：2020-01-01 00:00:00

abstract：:Five programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for the treatment of locally advanced or metastatic urothelial carcinoma of the bladder and the upper urinary tract. Following the FDA and EMA restrictions of first-line treatment with Atezolizumab and Pembrolizumab in platinum...

journal_title：Current drug targets

authors： Gevaert T,Cimadamore A,Montironi R,Eckstein M

更新日期：2020-05-09 00:00:00

abstract：:Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...

journal_title：Current drug targets

authors： Yang H,Dou QP

更新日期：2010-06-01 00:00:00

abstract：:Stroke is one of the major causes of mortality and disability in adults in industrialized countries. Despite numerous preclinical studies and clinical trials in the field of cerebral ischemia, no pharmacological agent has been validated in the treatment of acute ischemic, except thrombolysis. Cerebral ischemia is not ...

journal_title：Current drug targets

authors： Ouk T,Potey C,Gautier S,Bastide M,Deplanque D,Staels B,Duriez P,Leys D,Bordet R

更新日期：2013-06-01 00:00:00

abstract：:Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...

journal_title：Current drug targets

authors： Huang Y,Fu P,Fan W

更新日期：2013-07-01 00:00:00

abstract：:Type 2 diabetes, which has dramatically increased during the last decade normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. Numerous human epidemiological stu...

journal_title：Current drug targets

authors： Reusens B,Ozanne SE,Remacle C

更新日期：2007-08-01 00:00:00

abstract：:Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...

journal_title：Current drug targets

authors： Dhote V,Samundre P,Ganeshpurkar A,Upaganlawar A

更新日期：2020-12-09 00:00:00

abstract：:The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...

journal_title：Current drug targets

authors： Epifano F,Curini M,Marcotullio MC,Genovese S

更新日期：2011-12-01 00:00:00

abstract：:The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/beta-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. ...

journal_title：Current drug targets

authors： Qi J,Zhu YQ

更新日期：2008-07-01 00:00:00

abstract：:Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without damaging normal cells. In recent years, ACP has been pre-clinically used for cancer treatment. Therefore, accurate identification of ACPs will promote their clinical applications. In contrast to labor-intensive experimental techniq...

journal_title：Current drug targets

authors： Feng P,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:The androgen receptor (AR) signalling pathway remains a key driver of prostate cancer progression despite castrate levels of testosterone in advanced disease. The androgen biosynthesis inhibitor abiraterone and the anti-androgen enzalutamide have been shown to prolong survival in randomized clinical trials both pre-an...

journal_title：Current drug targets

authors： Assi R,Temraz S,Shamseddine A,Mukherji D

更新日期：2016-01-01 00:00:00