Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy.

abstract：:Dysbiosis has been repeatedly observed in inflammatory bowel disease (IBD) and is now recognized as an essential factor in the gut inflammatory process. IBD is a significant burden to health-care systems, mainly due to treatment-related costs. Available treatments have several limitations: up to 30% of patients are pr...

journal_title：Current drug targets

authors： Zatorski H,Nakov R

更新日期：2020-01-01 00:00:00

abstract：:One approach to identify new drugs with antimicrobial activities is to screen large libraries of molecules directly for their capacity to block the growth of bacterial or fungal monocultures. A more relevant way to assess both a product's efficacy and its potential cytotoxicity is undoubtedly to use an in vivo infecti...

journal_title：Current drug targets

authors： Squiban B,Kurz CL

更新日期：2011-06-01 00:00:00

abstract：:The complexity of the central nervous system (CNS) exposes it to a number of different diseases, often caused by only small variations in gene sequence or expression level. Antisense oligonucleotides and RNA interference-mediated therapies hold great promise for the treatment of CNS diseases in which neurodegeneration...

journal_title：Current drug targets

authors： Forte A,Cipollaro M,Cascino A,Galderisi U

更新日期：2005-02-01 00:00:00

abstract：:Epithelia are the layers of cells that form barriers between external milieu and underlying tissues and thus, are important components of most organs of the body. Epithelial layers of organs, such as the lung, are exposed to various challenges resulting in frequent injury. Epithelial wound healing represents an import...

journal_title：Current drug targets

authors： Allahverdian S,Patchell BJ,Dorscheid DR

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...

journal_title：Current drug targets

authors： Virgili G,Novielli N,Menchini F,Murro V,Giacomelli G

更新日期：2011-02-01 00:00:00

abstract：:The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discuss...

journal_title：Current drug targets

authors： Coates L,Myles DA

更新日期：2004-02-01 00:00:00

abstract：:Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkh...

journal_title：Current drug targets

authors： Velikova N,Wells JM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds...

journal_title：Current drug targets

authors： Farhat SM,Ahmed T

更新日期：2017-01-01 00:00:00

abstract：:Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...

journal_title：Current drug targets

authors： Kulkarni S,Ghosh SP,Hauer-Jensen M,Kumar KS

更新日期：2010-11-01 00:00:00

abstract：:Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...

journal_title：Current drug targets

authors： Tan JX,Lv H,Wang F,Dao FY,Chen W,Ding H

更新日期：2019-01-01 00:00:00

abstract：:Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytom...

journal_title：Current drug targets

authors： Hasanpourghadi M,Looi CY,Pandurangan AK,Sethi G,Wong WF,Mustafa MR

更新日期：2017-01-01 00:00:00

abstract：:Candida species, in particular C. albicans, represent a major threat to immunocompromised patients. Able to exist as a commensal on mucosal surfaces of healthy individuals, these opportunistic fungi frequently cause superficial infections of mucosae and skin. Furthermore, in hospital settings, Candida species may caus...

journal_title：Current drug targets

authors： Mavor AL,Thewes S,Hube B

更新日期：2005-12-01 00:00:00

abstract：:Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by chronic inflammation affecting the colonic mucosa, that can extend to the whole large bowel. The severity of mucosal lesions directly reflects the disease activity and severity and may be prognostic for an aggressive behavior of the pathol...

journal_title：Current drug targets

authors： Fiorino G,Cesarini M,Indriolo A,Malesci A

更新日期：2011-09-01 00:00:00

abstract：:The production of reactive oxygen species is a normal part of cell physiology, but many internal and external stimuli are able to trigger the production of excess levels of oxidants that are potentially damaging. The threat of oxidative damage is particularly significant to DNA, as damaged bases can interfere with rep...

journal_title：Current drug targets

authors： Shaukat Z,Liu D,Hussain R,Khan M,Gregory SL

更新日期：2016-01-01 00:00:00

abstract：:Breast cancer is the most common cancer in women in the United States, with African-American (AA) women showing significantly higher rates than Caucasian-American (CA) women do. The reason for this racial disparity remains unknown, and factors that might be responsible for the differences in incidence and mortality ha...

journal_title：Current drug targets

authors： Rahman KM,Sakr WA

更新日期：2012-12-01 00:00:00

abstract：:Nature provides science and society with a virtually unlimited supply of structurally diverse and biologically active molecules; the natural products. While some are directly useful in commercial applications, others are valuable for studying and understanding biological phenomena at the molecular level. An example is...

journal_title：Current drug targets

authors： Nilsson J,Sterner O

更新日期：2011-10-01 00:00:00

abstract：:The rationale for surfactant replacement therapy in patients with acute respiratory distress syndrome (ARDS) is to restore the normal composition of the surfactant system, as well as to overcome ongoing inactivation of present surfactant. Indeed, surfactant replacement therapy can normalize the composition of the surf...

journal_title：Current drug targets

authors： Schultz MJ,Kesecioglu J

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative patient outcome in osteosarcoma. Third-generation nitrogen-containing bisphosphonates, such as zoledronic acid, have been shown to reduce ...

journal_title：Current drug targets

authors： Ouyang Z,Li H,Zhai Z,Xu J,Dass CR,Qin A,Dai K

更新日期：2018-01-01 00:00:00

abstract：:Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

journal_title：Current drug targets

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2017-01-01 00:00:00

abstract：:The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may interfere with gene expression and, in addition to potential therapeutic applications, can be helpful for the investigation of DNA processing, chromatin packag...

journal_title：Current drug targets

authors： Besch R,Giovannangeli C,Degitz K

更新日期：2004-11-01 00:00:00

abstract：:The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

journal_title：Current drug targets

authors： De Gaudio AR,Rinaldi S

更新日期：2005-11-01 00:00:00

abstract：:Retinal neovascularization and macular edema are central features of diabetic retinopathy, a major cause of blindness in working age adults. The currently established treatment for diabetic retinopathy targets the vascular pathology by laser photocoagulation. This approach is associated with significant adverse effect...

journal_title：Current drug targets

authors： Caldwell RB,Bartoli M,Behzadian MA,El-Remessy AE,Al-Shabrawey M,Platt DH,Liou GI,Caldwell RW

更新日期：2005-06-01 00:00:00

abstract：:The incidence of lung cancer in 2007 is estimated to be 213,380 with 160,390 deaths in the United States. It will contribute to 31% of male and 26% of female cancer-related deaths and is the largest cause of cancer-related mortality in both men and women. Despite some advances in the treatment of advanced non-small ce...

journal_title：Current drug targets

authors： Chen M,Shao W,He J,Wang D

更新日期：2010-01-01 00:00:00

abstract：:Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. Whi...

journal_title：Current drug targets

authors： Oliveira-Paula GH,Tanus-Santos JE

更新日期：2019-01-01 00:00:00

abstract：:The etiopathogenesis of Crohn's disease (CD) and ulcerative Colitis (UC), the two major forms of inflammatory bowel disease (IBD), is still unknown. Although the exact cause and mechanisms of both IBD have yet to be completely understood, it is widely accepted that both CD and UC result from an inappropriate immune re...

journal_title：Current drug targets

authors： Stefanelli T,Malesci A,Repici A,Vetrano S,Danese S

更新日期：2008-05-01 00:00:00

abstract：:Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recogn...

journal_title：Current drug targets

authors： Passarelli AL,Guarino LA

更新日期：2007-10-01 00:00:00

abstract：:Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to ov...

journal_title：Current drug targets

authors： Guiard BP,Lanfumey L,Gardier AM

更新日期：2006-02-01 00:00:00

abstract：:The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...

journal_title：Current drug targets

authors： Perrotti D,Silvestri G,Stramucci L,Yu J,Trotta R

更新日期：2017-01-01 00:00:00

abstract：:Efforts to interfere with the initiation and promotion of breast and other cancers by endocrine manipulation are not new. It is of obvious benefit to cancer patients to administer substances that combine minimal general toxicity with maximal oestrogen inhibition. Raloxifene is a relatively recent addition to a group o...

journal_title：Current drug targets

authors： Kellen JA

更新日期：2001-12-01 00:00:00

abstract：:Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Tra...

journal_title：Current drug targets

authors： Vanhamme L

更新日期：2008-11-01 00:00:00