Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.

abstract：:Hypertriglyceridaemia is associated with insulin resistance, hypertension, obesity and diabetes. The management of hypertriglyceridaemia and atherogenic dyslipidaemias increasingly involves the use of several drugs for different aspects of the metabolic syndrome. This review highlights the agents for treatment of bloo...

journal_title：Current drug targets

authors： Viljoen A,Wierzbicki AS

更新日期：2009-04-01 00:00:00

abstract：:Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...

journal_title：Current drug targets

authors： Tan JX,Lv H,Wang F,Dao FY,Chen W,Ding H

更新日期：2019-01-01 00:00:00

abstract：:Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative stress makes cancer cells vulnerable to agents that further augment ROS levels, the use of pro-oxidant agents is emerging as an exciting strategy to selectively targ...

journal_title：Current drug targets

authors： Martin-Cordero C,Leon-Gonzalez AJ,Calderon-Montano JM,Burgos-Moron E,Lopez-Lazaro M

更新日期：2012-07-01 00:00:00

abstract：AIMS:The aim of this study is to provide an overview of several emerging anti-diabetic molecules. BACKGROUND:Diabetes is a complex metabolic disorder involving the dysregulation of glucose homeostasis at various levels. Insulin, which is produced by β-pancreatic cells, is a chief regulator of glucose metabolism, regul...

journal_title：Current drug targets

authors： Wu P,Liu Z,Jiang X,Fang H

更新日期：2020-01-01 00:00:00

abstract：:The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...

journal_title：Current drug targets

authors： Epifano F,Curini M,Marcotullio MC,Genovese S

更新日期：2011-12-01 00:00:00

abstract：:Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of...

journal_title：Current drug targets

authors： Bruining DH

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：:Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...

journal_title：Current drug targets

authors： Lahm A,Yagnik A,Tramontano A,Koch U

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins...

journal_title：Current drug targets

authors： Chowdhury D,Kumar D,Sarma P,Tangutur AD,Bhadra MP

更新日期：2017-11-30 00:00:00

abstract：:Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...

journal_title：Current drug targets

authors： Xiong X,Xu Z,Yang Z,Liu Y,Wang D,Dong M,Parker EJ,Zhu W

更新日期：2013-06-01 00:00:00

abstract：:The heterogeneity of proteoglycans (PG)s contributes to their functional diversity. Many functions depend on their ability to bind and modulate the activity of components of the extracellular matrix (ECM). The ability of PGs to interact with other molecules, such as growth factors, is largely determined by the fine st...

journal_title：Current drug targets

authors： Fjeldstad K,Kolset SO

更新日期：2005-09-01 00:00:00

abstract：:The development of databases devoted to biological information opened the possibility to integrate, query and analyze biological data obtained from several sources that otherwise would be scattered through the web. Several issues arise in the handling of biological information, mainly due to the diversity of biologica...

journal_title：Current drug targets

authors： Timmers LF,Pauli I,Barcellos GB,Rocha KB,Caceres RA,de Azevedo WF Jr,Soares MB

更新日期：2009-03-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability in Western countries. The most common cause of CVD derives from the harmful effects of acute myocardial ischemia and subsequent reperfusion injury. Cardioprotection against acute ischemia/ reperfusion injury is made possible b...

journal_title：Current drug targets

authors： Penna C,Granata R,Tocchetti CG,Gallo MP,Alloatti G,Pagliaro P

更新日期：2015-01-01 00:00:00

abstract：:Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), have been identified as potential drug ta...

journal_title：Current drug targets

authors： Vassilev AO,Tibbles HE,DuMez D,Venkatachalam TK,Uckun FM

更新日期：2006-03-01 00:00:00

abstract：:In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...

journal_title：Current drug targets

authors： Marcu KB,Otero M,Olivotto E,Borzi RM,Goldring MB

更新日期：2010-05-01 00:00:00

abstract：:Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biolo...

journal_title：Current drug targets

authors： Gulcan HO,Orhan IE

更新日期：2021-01-20 00:00:00

abstract：:Androgen and androgen receptor (AR) play a critical role in the development of prostate cancer. Androgen deprivation therapy (ADT) has become the therapeutic mainstay for patients with metastatic prostate cancer. ADT can reduce the serum testosterone level from the normal range between 500 and 600 ng/dl to the castrat...

journal_title：Current drug targets

authors： Hara N,Nishiyama T

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's, a degenerative cause of the brain cells, is called as a progressive neurodegenerative disease and appears to have a heterogeneous etiology with main emphasis on amyloid-cascade and hyperphosphorylated tau-cascade hypotheses, that are directly linked with macromolecules called enzymes such as β- & γ-secret...

journal_title：Current drug targets

authors： Alam J,Sharma L

更新日期：2019-01-01 00:00:00

abstract：:It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders. Translation of the knowledge gained from CR research in animal models to disease prevention stra...

journal_title：Current drug targets

authors： Duan W,Ross CA

更新日期：2010-10-01 00:00:00

abstract：:To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...

journal_title：Current drug targets

authors： Ve T,Gay NJ,Mansell A,Kobe B,Kellie S

更新日期：2012-10-01 00:00:00

abstract：:Our aim was to provide a narrative review regarding the prevalence, the associated pathophysiologic pathways and the potential management methods of sexual dysfunction related to ablative surgical techniques for Benign Prostatic Enlargement (BPE). Men suffering from BPE are at high risk of sexual dysfunction due to th...

journal_title：Current drug targets

authors： Mykoniatis I,Renterghem KV,Sokolakis I

更新日期：2021-01-01 00:00:00

abstract：:It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheuma...

journal_title：Current drug targets

authors： Morimoto J,Kon S,Matsui Y,Uede T

更新日期：2010-04-01 00:00:00

abstract：:Using a portable infusion pump, intravenous opioid patient-controlled analgesia (PCA) permits a patient to self-deliver a small bolus of opioid to achieve prompt relief without over sedation. Use of PCA for pain management is increasing in hospitals, largely because it can provide equivalent or better analgesia than c...

journal_title：Current drug targets

authors： Mann C,Ouro-Bang'na F,Eledjam JJ

更新日期：2005-11-01 00:00:00

abstract：:A group of oxytocinergic neurons originating in the paraventricular nucleus of the hypothalamus and projecting to extrahypothalamic brain areas (e.g. hippocampus, medulla oblongata and spinal cord) control penile erection. Activation of these neurons by dopamine and dopamine agonists, excitatory amino acids (N-methyl-...

journal_title：Current drug targets

authors： Melis MR,Argiolas A

更新日期：2003-01-01 00:00:00

abstract：:According to international guidelines, treatment of cervical cancer (CC) consists of surgery in early stages and of chemoradiation in locally advanced disease. Metastatic disease is usually treated with palliative chemotherapeutic regimens, but cytostatic drugs present significant side effects and show limited activit...

journal_title：Current drug targets

authors： Tomao F,Di Tucci C,Imperiale L,Boccia SM,Marchetti C,Palaia I,Muzii L,Panici PB

更新日期：2014-01-01 00:00:00

abstract：:The liver is essential for the control of glucose and lipid metabolism. Excessive accumulation of fat in the liver disturbs its function and leads to the development of fatty liver diseases. The nonalcoholic fatty liver disease (NAFLD) is a common type of fatty liver disease found in patients who have not consumed sig...

journal_title：Current drug targets

authors： Chen G

更新日期：2015-01-01 00:00:00

abstract：:Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

journal_title：Current drug targets

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2017-01-01 00:00:00

abstract：:The α7-nAChR plays critical roles in numerous organs and cells by regulating highly organ and cell typespecific functions. In this special issue different Authors have contributed to clarify the different roles played by the α7- nAChR. Post-translational processes such as receptor "underactivation" or "overactivation"...

journal_title：Current drug targets

authors： Russo P,Cardinale A,Shuller H

更新日期：2012-05-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a major type of ionotropic glutamate receptor. Many studies have shown that NMDA receptors play a pivotal role in the central nervous system (CNS) under both physiological and pathological conditions. The functional diversity of NMDA receptors can be mainly attributed to the...

journal_title：Current drug targets

authors： Li ST,Ju JG

更新日期：2012-02-01 00:00:00

abstract：:Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...

journal_title：Current drug targets

authors： Improta G,Broccardo M

更新日期：2006-08-01 00:00:00