An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes.

abstract：:Prostaglandins serve as the connecting link between inflammation and cancer. mPGES1, the downstream enzyme in the prostaglandin pathway is considered a better target than COX-2 against the progression of cancer due to the cardiovascular and other complications associated with the inhibition of the latter. Despite the ...

journal_title：Current drug targets

authors： Ramanan M,Doble M

更新日期：2017-01-01 00:00:00

abstract：:Disorders of emotion regulation such as anxiety disorders and depression are common and yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the regulation of emotion. Mice with targeted deletion of genes encoding mediators of the serotonergic transmission have proven to be a powerful to...

journal_title：Current drug targets

authors： Araragi N,Lesch KP

更新日期：2013-05-01 00:00:00

abstract：:Resveratrol (3,4',5 tri-hydroxystilbene) is a phytoalexin produced in hudge amount in grapevine skin in response to infection by Bothrytis cinerea. This production of resveratrol blocks the proliferation of the pathogen, thereby acting as a natural antibiotic. Numerous studies have reported interesting properties of t...

journal_title：Current drug targets

authors： Delmas D,Lançon A,Colin D,Jannin B,Latruffe N

更新日期：2006-04-01 00:00:00

abstract：:Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. Whi...

journal_title：Current drug targets

authors： Oliveira-Paula GH,Tanus-Santos JE

更新日期：2019-01-01 00:00:00

abstract：:Stroke is one of the major causes of mortality and disability in adults in industrialized countries. Despite numerous preclinical studies and clinical trials in the field of cerebral ischemia, no pharmacological agent has been validated in the treatment of acute ischemic, except thrombolysis. Cerebral ischemia is not ...

journal_title：Current drug targets

authors： Ouk T,Potey C,Gautier S,Bastide M,Deplanque D,Staels B,Duriez P,Leys D,Bordet R

更新日期：2013-06-01 00:00:00

abstract：:Inflammation plays a central role in chronic obstructive pulmonary disease (COPD). COPD related inflammation is less responsive to inhaled steroids compared to asthma. There are three major novel anti-inflammatory approaches to the management of COPD. The first approach is phosphodiesterase inhibitors, such as roflumi...

journal_title：Current drug targets

authors： Loukides S,Bartziokas K,Vestbo J,Singh D

更新日期：2013-02-01 00:00:00

abstract：:Various herpes- and poxviruses contain DNA sequences encoding proteins with homology to cellular chemokine receptors, which belong to the family of G protein-coupled receptors (GPCRs). Since GPCRs play a crucial role in cellular communication and chemokine receptors play a prominent role in the immune system, the vira...

journal_title：Current drug targets

authors： Smit MJ,Vink C,Verzijl D,Casarosa P,Bruggeman CA,Leurs R

更新日期：2003-07-01 00:00:00

abstract：:5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. The pathophysiological effects of LTs can be modulated by the selective inhibition o...

journal_title：Current drug targets

authors： Anwar Y,Sabir JS,Qureshi MI,Saini KS

更新日期：2014-04-01 00:00:00

abstract：:Transport molecules can significantly affect the pharmacodynamics and pharmacokinetics of drugs. An important transport molecule, the 170 kDa P-glycoprotein (Pgp), is constitutively expressed at several organ sites in the human body. Pgp is expressed at the blood-brain barrier, in the kidneys, liver, intestines and in...

journal_title：Current drug targets

authors： Liang XJ,Aszalos A

更新日期：2006-08-01 00:00:00

abstract：:In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...

journal_title：Current drug targets

authors： Marcu KB,Otero M,Olivotto E,Borzi RM,Goldring MB

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：:Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...

journal_title：Current drug targets

authors： Sakane F,Imai S,Kai M,Yasuda S,Kanoh H

更新日期：2008-08-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by relatively selective degeneration of dopaminergic neurons in the substantia nigra and loss of dopamine in the striatum. More than 50 epidemiological studies confirmed the low incidence of PD in smokers. Examining the distribution of subtypes of nicotinic acetylcholine recep...

journal_title：Current drug targets

authors： Kawamata J,Suzuki S,Shimohama S

更新日期：2012-05-01 00:00:00

abstract：:Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative stress makes cancer cells vulnerable to agents that further augment ROS levels, the use of pro-oxidant agents is emerging as an exciting strategy to selectively targ...

journal_title：Current drug targets

authors： Martin-Cordero C,Leon-Gonzalez AJ,Calderon-Montano JM,Burgos-Moron E,Lopez-Lazaro M

更新日期：2012-07-01 00:00:00

abstract：:In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...

journal_title：Current drug targets

authors： Suarez-Kurtz G,Pena SD

更新日期：2006-12-01 00:00:00

abstract：:Programmed cell death, commonly associated with the term apoptosis, is an integrated intracellular program that plays a critical role in lymphoid tissue homeostasis. Alterations in this highly regulated process is a common feature of most lymphoid malignancies, thus facilitating tumor escape from traditional chemother...

journal_title：Current drug targets

authors： Saborit-Villarroya I,Roué G,López-Guerra M,Alonso R,Xargay-Torrent S,Rosich L,Colomer D

更新日期：2010-07-01 00:00:00

abstract：:Saponins are plant glycosides that consist of a steroid, steroid alkaloid or triterpenoid aglycone and one or more sugar chains that are covalently linked by glycosidic binding to the aglycone. Glucose, galactose, glucuronic acid, xylose and rhamnose are commonly bound monosaccharides. Saponins are found in all organs...

journal_title：Current drug targets

authors： Fuchs H,Bachran D,Panjideh H,Schellmann N,Weng A,Melzig MF,Sutherland M,Bachran C

更新日期：2009-02-01 00:00:00

abstract：:Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical appl...

journal_title：Current drug targets

authors： Gupta PN,Vyas SP

更新日期：2011-04-01 00:00:00

abstract：:Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity. Conjugation of Ub or UBLs to target proteins is dynamica...

journal_title：Current drug targets

authors： Li J,Johnson JA,Su H

更新日期：2018-01-01 00:00:00

abstract：:The sialyltransferase family represents a group of enzymes that transfers sialic acid from its common nucleotide sugar donor, CMP-NeuAc, to the terminal carbohydrates group of various glycoproteins and glycolipids. Cloning of these enzymes from mammalian sources indicated these are all type II membrane proteins with t...

journal_title：Current drug targets

authors： Datta AK

更新日期：2009-06-01 00:00:00

abstract：:Methionine aminopeptidases (MetAP) are intracellular metalloproteins responsible for the removal of the initiator NH(2)-terminal methionine from newly synthesized proteins, thereby facilitating their intracellular translocation from the ribosome. Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), whic...

journal_title：Current drug targets

authors： Mauriz JL,Martín-Renedo J,García-Palomo A,Tuñón MJ,González-Gallego J

更新日期：2010-11-01 00:00:00

abstract：:Excessive production of reactive oxygen species is an important mechanism underlying the pathogenesis of diabetes associated macrovascular and microvascular complications including diabetic nephropathy. Diabetic nephropathy is characterized by glomerular enlargement, early albuminuria and progressive glomerulosclerosi...

journal_title：Current drug targets

authors： Arora MK,Singh UK

更新日期：2014-05-01 00:00:00

abstract：:Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal...

journal_title：Current drug targets

authors： Barton LA,Ren J

更新日期：2018-01-01 00:00:00

abstract：:The complexity of the central nervous system (CNS) exposes it to a number of different diseases, often caused by only small variations in gene sequence or expression level. Antisense oligonucleotides and RNA interference-mediated therapies hold great promise for the treatment of CNS diseases in which neurodegeneration...

journal_title：Current drug targets

authors： Forte A,Cipollaro M,Cascino A,Galderisi U

更新日期：2005-02-01 00:00:00

abstract：:NMDA receptors are a subclass of excitatory, ionotropic L-glutamate neurotransmitter receptors. They are.heteromeric, integral membrane proteins being formed by the assembly of the obligatory NR1 subunit together with modulatory NR2 subunits of which four different types, NR2A-NR2D, have been described. This results i...

journal_title：Current drug targets

authors： Stephenson FA

更新日期：2001-09-01 00:00:00

abstract：:The use of predictive biomarkers provides potential individualized cancer therapeutic options to prevent therapy failure as well as serious toxicities. Several recent studies showed that predictive and prognostic biomarkers are a notable personalized strategy to improve patients' care in several cancers. Trabectedin (...

journal_title：Current drug targets

authors： Souid S,Aissaoui D,Srairi-Abid N,Essafi-Benkhadir K

更新日期：2020-01-01 00:00:00

abstract：:Mannosylphospho dolichol synthase (DPMS) catalyzes the transfer reaction GDP-mannose + Dol-P <--> Dol-P-Man + GDP, a 'key step' in the assembly of lipid-linked oligosaccharide (LLO) and a pre-requisite for asparagine-linked (N-linked) protein glycosylation. DPMS is present from a protozoan parasite to human, and its s...

journal_title：Current drug targets

authors： Baksi K,Tavárez-Pagán JJ,Martínez JA,Banerjee DK

更新日期：2008-04-01 00:00:00

abstract：:Using a portable infusion pump, intravenous opioid patient-controlled analgesia (PCA) permits a patient to self-deliver a small bolus of opioid to achieve prompt relief without over sedation. Use of PCA for pain management is increasing in hospitals, largely because it can provide equivalent or better analgesia than c...

journal_title：Current drug targets

authors： Mann C,Ouro-Bang'na F,Eledjam JJ

更新日期：2005-11-01 00:00:00

abstract：:Nowadays, natural compounds of plant origin with anticancer effects have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway that may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve artic...

journal_title：Current drug targets

authors： Forouzanfar F,Mousavi SH

更新日期：2020-01-01 00:00:00

abstract：:It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of osteoarthritis. This might be related to continuous mechanical wear and tear and/or result from time/age-related modifications of cartilage matrix components. Also a mere loss of viable cells over ...

journal_title：Current drug targets

authors： Aigner T,Haag J,Martin J,Buckwalter J

更新日期：2007-02-01 00:00:00