Abstract:
:Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative stress makes cancer cells vulnerable to agents that further augment ROS levels, the use of pro-oxidant agents is emerging as an exciting strategy to selectively target tumor cells. Natural products have provided a significant contribution to the development of several drugs currently used in cancer chemotherapy. Although many natural products are known to affect the redox state of the cell, most studies on these compounds have focused on their antioxidant activity instead of on their pro-oxidant properties. This article provides an overview of natural products with pro-oxidant and anticancer activities, with special focus on plant secondary metabolites, and discusses their possible use as cancer chemotherapeutic agents.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Martin-Cordero C,Leon-Gonzalez AJ,Calderon-Montano JM,Burgos-Moron E,Lopez-Lazaro Mdoi
10.2174/138945012802009044subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1006-28issue
8eissn
1389-4501issn
1873-5592pii
CDT-EPUB-20120517-23journal_volume
13pub_type
杂志文章,评审abstract::Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesi...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450115666140930150047
更新日期:2014-01-01 00:00:00
abstract::Fracture healing is a process of recovering injured bone tissue forms and functions. Osteoporosis can delay the healing process, which contributes to personal suffering and loss of activities. Osteoporosis patients tend to lose bone mass at the metaphyseal region which require treatment to increase bone mass. Postmeno...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/13894501113149990195
更新日期:2013-12-01 00:00:00
abstract::Type 2 diabetes, which has dramatically increased during the last decade normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. Numerous human epidemiological stu...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007781386866
更新日期:2007-08-01 00:00:00
abstract::Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different c...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666191015211737
更新日期:2020-01-01 00:00:00
abstract::Adipose tissue plays an active role in energy balance because it is not only a lipid storing and mobilizing tissue but consists of functionally specialized tissues able to produce heat (in brown adipose tissue) and to produce or release a vast number of so called adipokines or adipocytokines. These consist of polypept...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043490523
更新日期:2004-04-01 00:00:00
abstract::Epigenetic modifications ensure the maintenance of normal cellular functions, and their dysregulation is frequently found in many disease states, including cancer. Nowadays, the most studied epigenetic dysregulation associated with tumorigenesis, cancer progression and metastasis refers to the variations in DNA methyl...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200325093104
更新日期:2020-01-01 00:00:00
abstract::The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011798184128
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009788982513
更新日期:2009-08-01 00:00:00
abstract::Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterize...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033490902
更新日期:2003-08-01 00:00:00
abstract::Calcium is a key determinant of cardiac excitation, contraction and relaxation. Cardiac excitation and contraction is powered by ATP that is synthesized within mitochondria via a calcium-dependent process known as oxidative phosphorylation. During this process oxygen molecules within the mitochondria are converted to ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011795378603
更新日期:2011-05-01 00:00:00
abstract::The overuse of antibiotics which exerts the selective pressure for bacterial pathogens has facilitated the spread of antibiotics' resistance. Metallo-β-lactamases (MβLs) are zinc enzymes produced by an increasing number of bacterial pathogens. They can readily cleave carbapenems and most other β-lactams that are mains...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140326094504
更新日期:2014-01-01 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314060009
更新日期:2013-06-01 00:00:00
abstract::The etiopathogenesis of Crohn's disease (CD) and ulcerative Colitis (UC), the two major forms of inflammatory bowel disease (IBD), is still unknown. Although the exact cause and mechanisms of both IBD have yet to be completely understood, it is widely accepted that both CD and UC result from an inappropriate immune re...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008784221170
更新日期:2008-05-01 00:00:00
abstract::Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160622220915
更新日期:2018-01-01 00:00:00
abstract::Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytom...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160401124842
更新日期:2017-01-01 00:00:00
abstract::Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012804545452
更新日期:2012-12-01 00:00:00
abstract::The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945005774574542
更新日期:2005-11-01 00:00:00
abstract::Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/13894501113149990161
更新日期:2013-07-01 00:00:00
abstract::Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biolo...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450122666210120144921
更新日期:2021-01-20 00:00:00
abstract::As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the β-lactam ring. Later, an enzyme mediated by an R-...
journal_title:Current drug targets
pub_type: 历史文章,杂志文章,评审
doi:10.2174/1389450116666151001112859
更新日期:2016-01-01 00:00:00
abstract::Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201209202247
更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180115164103
更新日期:2018-01-01 00:00:00
abstract::Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external to the membrane. TM binds thrombin changing thrombin's substrate specificity fro...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012799424606
更新日期:2012-03-01 00:00:00
abstract::An understanding of the historical paths that have lead to our current state of knowledge in the field of platelet studies can be both illuminating and inspiring. Considering that the existence and function of platelets were initially described just barely over 100 years ago it is exciting to recognize how far our kno...
journal_title:Current drug targets
pub_type: 历史文章,杂志文章
doi:10.2174/138945011797635858
更新日期:2011-11-01 00:00:00
abstract::Human proteins are subjected to more than 200 known post-translational modifications (PTMs) (e.g., phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation, Nacetylation, and citrullination) and these PTMs can alter protein structure and function with consequent effects on the multitude of pathways...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150202160954
更新日期:2015-01-01 00:00:00
abstract::Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033491109
更新日期:2003-05-01 00:00:00
abstract::The sphingomyelin (SM) pathway is an ubiquitous and evolutionarily conserved signaling system in which ceramide (CA), generated from SM by the action of various isoforms of sphingomyelinases (SMases) functions as an important second messenger. Recent evidence suggests that branching pathways of sphingolipid metabolism...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450003349272
更新日期:2000-09-01 00:00:00
abstract::Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases. For example, Zinostatin s...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
abstract::The last 15 years have witnessed a resurgence of the role of surgical options for prevention of ischemic stroke. The landmark randomized trials including NASCET and ECST were published and explored the role of carotid endarterectomy in this regard. Patients with high grade stenosis of the internal carotid artery (> or...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007781077391
更新日期:2007-07-01 00:00:00
abstract::Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Tra...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008786786064
更新日期:2008-11-01 00:00:00