Abstract:
BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic and vascular risk. For example, ectopic fat in perivascular tissue promotes atherosclerotic plaque formation in the arterial wall. OBJECTIVE:Recently, it has been reported that ectopic fat (adipocyte) in the vascular wall of an abdominal aortic aneurysm (AAA) is present in both human and experimental animal models. The pathological significance of adipocytes in the AAA wall has not been fully understood. In this review, we summarized the functions of adipocytes and discussed potential new drugs that target vascular adipocytes for AAA treatment. RESULT:Previous studies suggest that adipocytes in vascular wall play an important role in the development of AAA. CONCLUSION:Adipocytes in the vascular wall could be novel targets for the development of AAA therapeutic drugs.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Kugo H,Moriyama T,Zaima Ndoi
10.2174/1389450119666180115164103subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1228-1232issue
11eissn
1389-4501issn
1873-5592pii
CDT-EPUB-87937journal_volume
19pub_type
杂志文章,评审abstract:BACKGROUND:Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension. OBJECTIVE:Nanotechnology in drug delivery has been evid...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180131105822
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abstract::Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...
journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666161227125121
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abstract::The androgen receptor (AR) signalling pathway remains a key driver of prostate cancer progression despite castrate levels of testosterone in advanced disease. The androgen biosynthesis inhibitor abiraterone and the anti-androgen enzalutamide have been shown to prolong survival in randomized clinical trials both pre-an...
journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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abstract::The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006775515428
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abstract::Adenocarcinoma of the prostate is the most common type of cancer, excluding skin cancer, and the second leading cause of cancer death in adult men in the United States. The lifetime risk for developing symptomatic prostate cancer is one in five for an American man. A pivotal step in carcinogenesis is a shift in the ba...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章,评审
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abstract::Vaccines have been described as "weapons of mass protection". The eradication of many diseases is testament to their utility and effectiveness. Nevertheless, many vaccine preventable diseases remain prevalent because of political and economic barriers. Additionally, the effects of immaturity and old age, therapies tha...
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abstract:BACKGROUND:Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative patient outcome in osteosarcoma. Third-generation nitrogen-containing bisphosphonates, such as zoledronic acid, have been shown to reduce ...
journal_title:Current drug targets
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abstract::The last decade has witnessed the introduction of a large number of novel, molecularly targeted agents into the therapeutic armamentarium against diverse forms of cancer, including leukemia. Such agents include signal transduction, cell cycle, histone deacetylase, Hsp90, proteasome, and Bcl-2 family member inhibitors,...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007780830764
更新日期:2007-06-01 00:00:00
abstract::The contribution of proteases to developmental, physiological and pathological processes has been well accepted. Cleavage of matrix proteins is a key requirement for cell migration and remodeling of the extracellular environment. The constant process of matrix turnover is dependent on the delicate balance between degr...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00