Considering Circadian Pattern of Blood Pressure in the Treatment of Hypertension via Chronotherapy: A Conducive or Maladroit Approach.

Abstract:

:Medical chronobiology deals with the way body's rhythm influences a person's health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeostasis has been the base for the treatment of diseases. Little importance has been given in understanding biologic rhythms and their underlying mechanisms. Designing of cardiovascular drug is done to achieve a constant or near-constant effect throughout the 24-hour with the prescribed dose. However in many cases, medication requirement during night and day time are not the same. Body rhythms may have profound effect on the treatment outcomes. It is a wrongful approach to assume that a drug dosed in the morning or evening will have the same antihypertensive effect. The vast literature record of circadian variations in Blood Pressure (BP), heart rate, hormone secretion, and platelet aggregation are examples of the impact of chronobiology. In this study we analyze the effect of circadian pattern of blood pressure on action of various antihypertensives and investigate the perspective of chronotherapeutics- whether it is a fruitful approach and rationalize its utility in the treatment of hypertension.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

Das R,Mehta DK

doi

10.2174/1389450120666190527114529

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1244-1254

issue

12

eissn

1389-4501

issn

1873-5592

pii

CDT-EPUB-98625

journal_volume

20

pub_type

杂志文章,评审
  • Expression and functions of galectin-1 in sensory and motoneurons.

    abstract::Galectin-1 (Gal1) was the first identified member of the galectin family of beta-galactosidase-binding proteins. Gal1 has important roles in processes fundamental to growth and survival of an organism, including cell adhesion, cell proliferation and apoptosis, and is expressed in many tissues, including the nervous sy...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450054021864

    authors: Gaudet AD,Steeves JD,Tetzlaff W,Ramer MS

    更新日期:2005-06-01 00:00:00

  • Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences.

    abstract:BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009788982513

    authors: Dauri M,Faria S,Gatti A,Celidonio L,Carpenedo R,Sabato AF

    更新日期:2009-08-01 00:00:00

  • The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR).

    abstract::Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude the chemotherapic f...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006777709520

    authors: Teodori E,Dei S,Martelli C,Scapecchi S,Gualtieri F

    更新日期:2006-07-01 00:00:00

  • The therapeutic value of natural agents to treat miRNA targeted breast cancer in African-American and Caucasian-American women.

    abstract::Breast cancer is the most common cancer in women in the United States, with African-American (AA) women showing significantly higher rates than Caucasian-American (CA) women do. The reason for this racial disparity remains unknown, and factors that might be responsible for the differences in incidence and mortality ha...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945012804545461

    authors: Rahman KM,Sakr WA

    更新日期:2012-12-01 00:00:00

  • Novel targeted therapies to overcome trastuzumab resistance in HER2-overexpressing metastatic breast cancer.

    abstract::Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/13894501113149990161

    authors: Huang Y,Fu P,Fan W

    更新日期:2013-07-01 00:00:00

  • Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review.

    abstract::Due to potential health benefits and the general assumption that natural products are safe, there is an increasing trend in the general population - including pregnant women - to supplement their diet with flavonoid-based food supplements. In addition, preclinical studies aim to prevent developmental adverse effects i...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150804110049

    authors: Barenys M,Masjosthusmann S,Fritsche E

    更新日期:2017-01-01 00:00:00

  • Biomarkers, critical disease pathways, drug targets, and alternative medicine in male breast cancer.

    abstract::While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009787122842

    authors: Barh D

    更新日期:2009-01-01 00:00:00

  • Targeting transcription: a new concept of anti-inflammatory therapy of airway diseases.

    abstract::Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006777435326

    authors: Quarcoo D,Hamelmann E

    更新日期:2006-06-01 00:00:00

  • The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis.

    abstract::Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450118666170925154428

    authors: Mohamed N,Muhammad N,Shuid AN,Soelaiman IN

    更新日期:2018-01-01 00:00:00

  • Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy.

    abstract::Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. Whi...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450119666180816120816

    authors: Oliveira-Paula GH,Tanus-Santos JE

    更新日期:2019-01-01 00:00:00

  • Animal models of carcinogenesis in inflamed colorectum: potential use in chemoprevention study.

    abstract::Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945012804545452

    authors: Tanaka T

    更新日期:2012-12-01 00:00:00

  • Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents.

    abstract::The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a growth factor- and cytokine-inducible gene. Concomitant with these pharmaceutical successes is the advances in our understanding of the molecu...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450013348830

    authors: Kalgutkar AS,Zhao Z

    更新日期:2001-03-01 00:00:00

  • Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance.

    abstract::Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666151001105230

    authors: Turrini E,Ferruzzi L,Fimognari C

    更新日期:2017-01-01 00:00:00

  • Carbohydrates and epithelial repair - more than just post-translational modification.

    abstract::Epithelia are the layers of cells that form barriers between external milieu and underlying tissues and thus, are important components of most organs of the body. Epithelial layers of organs, such as the lung, are exposed to various challenges resulting in frequent injury. Epithelial wound healing represents an import...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006776818719

    authors: Allahverdian S,Patchell BJ,Dorscheid DR

    更新日期:2006-05-01 00:00:00

  • Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer.

    abstract::Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010791170842

    authors: Yang H,Dou QP

    更新日期:2010-06-01 00:00:00

  • Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatmen...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450120666191112141901

    authors: Bartoszek A,Fichna J,Tarasiuk A,Binienda A,Fabisiak A,Krajewska JB,Mosińska P,Niewinna K,Salaga M

    更新日期:2020-01-01 00:00:00

  • Study of Monocytes/Macrophages Stimuli as the Targets of Treating Inflammatory Bone Diseases.

    abstract::Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different c...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450120666191015211737

    authors: Liu Y,Cao Y,Smith W,He B,Yan L

    更新日期:2020-01-01 00:00:00

  • Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors.

    abstract::Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), have been identified as potential drug ta...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006776054997

    authors: Vassilev AO,Tibbles HE,DuMez D,Venkatachalam TK,Uckun FM

    更新日期:2006-03-01 00:00:00

  • Reproductive Toxicity of T Cells in Early Life: Abnormal Immune Development and Postnatal Diseases.

    abstract::Immunity is a balanced status with adequate biological defenses to recognize and fight "non-self", as well as adequate tolerance to recognize "self". To maintain this immune homeostasis, a well-organized T cell immune network is required, which in part depends on the well-controlled development of alternative effector...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666161124145641

    authors: Liu HX,Jiang A,Chen T,Qu W,Yan HY,Ping J

    更新日期:2017-01-01 00:00:00

  • Nanotheranostics in evidence based personalized medicine.

    abstract::Efficient drug delivery systems are exceedingly important for novel drug discovery. The evidence-based personalized medicine (EBPM) promises to deliver the right drug at the right time to a right patient as it covers clinicallysignificant genetic predisposition and chronopharmacological aspects of nanotheranostics. Re...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:

    authors: Sharma S

    更新日期:2014-01-01 00:00:00

  • Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.

    abstract::Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945008785132394

    authors: Sakane F,Imai S,Kai M,Yasuda S,Kanoh H

    更新日期:2008-08-01 00:00:00

  • EGFR Transactivation by Peptide G Protein-Coupled Receptors in Cancer.

    abstract::Lung cancer kills approximately 1.3 million citizens in the world annually. The tyrosine kinase inhibitors (TKI) erlotinib and gefitinib are effective anti-tumor agents especially in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The goal is to increase the potency of TKI in lung cancer p...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150107153609

    authors: Moody TW,Nuche-Berenguer B,Nakamura T,Jensen RT

    更新日期:2016-01-01 00:00:00

  • Can radiology replace endoscopy in IBD?

    abstract::Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945012802429633

    authors: Bruining DH

    更新日期:2012-09-01 00:00:00

  • Osteopontin; as a target molecule for the treatment of inflammatory diseases.

    abstract::It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheuma...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010790980321

    authors: Morimoto J,Kon S,Matsui Y,Uede T

    更新日期:2010-04-01 00:00:00

  • Aldose reductase, still a compelling target for diabetic neuropathy.

    abstract::Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945008783431781

    authors: Oates PJ

    更新日期:2008-01-01 00:00:00

  • TGF-betal/Smad signaling in prostate cancer.

    abstract::Adenocarcinoma of the prostate is the most common type of cancer, excluding skin cancer, and the second leading cause of cancer death in adult men in the United States. The lifetime risk for developing symptomatic prostate cancer is one in five for an American man. A pivotal step in carcinogenesis is a shift in the ba...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450033491118

    authors: Bello-DeOcampo D,Tindall DJ

    更新日期:2003-04-01 00:00:00

  • The Epitome of Novel Techniques and Targeting Approaches in Drug Delivery for Treating Lymphatic Filariasis.

    abstract:BACKGROUND:Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the ...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450121666200630111250

    authors: Shrivastava S,Gupta A,Kaur CD

    更新日期:2020-01-01 00:00:00

  • Novel imaging techniques in acute kidney injury.

    abstract::Imaging of the kidneys can provide valuable information in the work up and management of acute kidney injury. Several different imaging modalities are used to gather information on anatomy of the kidney, to rule out obstruction, differentiate acute kidney injury (AKI) and chronic kidney disease and to obtain informati...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009789753246

    authors: Kalantarinia K

    更新日期:2009-12-01 00:00:00

  • Cell death targeting therapies in B lymphoid malignancies.

    abstract::Programmed cell death, commonly associated with the term apoptosis, is an integrated intracellular program that plays a critical role in lymphoid tissue homeostasis. Alterations in this highly regulated process is a common feature of most lymphoid malignancies, thus facilitating tumor escape from traditional chemother...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010791320863

    authors: Saborit-Villarroya I,Roué G,López-Guerra M,Alonso R,Xargay-Torrent S,Rosich L,Colomer D

    更新日期:2010-07-01 00:00:00

  • Doxorubicin Action on Mitochondria: Relevance to Osteosarcoma Therapy?

    abstract:BACKGROUND:The mitochondria may very well determine the final commitment of the cell to death, particularly in times of energy stress. Cancer chemotherapeutics such as the anthracycline doxorubicin perturb mitochondrial structure and function in tumour cells, as evidenced in osteosarcoma, for which doxorubicin is used ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150416115852

    authors: Armstrong J,Dass CR

    更新日期:2018-01-01 00:00:00