Mechanism of Action: How Nano-Antimicrobials Act?

abstract：:The etiopathogenesis of Crohn's disease (CD) and ulcerative Colitis (UC), the two major forms of inflammatory bowel disease (IBD), is still unknown. Although the exact cause and mechanisms of both IBD have yet to be completely understood, it is widely accepted that both CD and UC result from an inappropriate immune re...

journal_title：Current drug targets

authors： Stefanelli T,Malesci A,Repici A,Vetrano S,Danese S

更新日期：2008-05-01 00:00:00

abstract：:In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...

journal_title：Current drug targets

authors： Marcu KB,Otero M,Olivotto E,Borzi RM,Goldring MB

更新日期：2010-05-01 00:00:00

abstract：:Thrombus formation at a site of arterial injury (eg, rupture of an atherosclerotic plaque in a carotid artery), a crucial step in the pathogenesis of cerebral ischemia, is initiated by the adhesion of platelets to the arterial wall. In vivo, activated platelets release adenosine diphosphate (ADP), whose binding to the...

journal_title：Current drug targets

authors： Giossi A,Pezzini A,Del Zotto E,Volonghi I,Costa P,Ferrari D,Padovani A

更新日期：2010-03-01 00:00:00

abstract：:FOXO transcription factors control proliferation, apoptosis, differentiation and metabolic processes. Loss of FOXO function has been identified in several human cancers, and results in increased cellular survival and a predisposition to neoplasia, especially in epithelial cancer. FOXO factors are therefore bona fide t...

journal_title：Current drug targets

authors： Monsalve M,Olmos Y

更新日期：2011-08-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a remarkably aggressive thoracic malignancy with a limited survival of only 5-12 months. However, MPM still remains unresponsive to conventional standards of treatment, including pleurectomy and decortication, extrapleural pneumonectomy for resectable disease with or without che...

journal_title：Current drug targets

authors： Cheng L,Li N,Xu XL,Mao WM

更新日期：2020-01-01 00:00:00

abstract：:Endogenous opioid peptides have been studied extensively as potential therapeutics for the treatment of pain. The major problems of using natural opioid peptides as drug candidates are their poor receptor specificity, metabolic instability and inability to reach the brain after systemic administration. A lot of synthe...

journal_title：Current drug targets

authors： Piekielna J,Perlikowska R,Gach K,Janecka A

更新日期：2013-06-01 00:00:00

abstract：:Currently, low density lipoprotein cholesterol (LDL-C) levels are the main, if not the only, lipid target in the effort to reduce cardiovascular disease (CVD) morbidity and mortality. Several primary and secondary CVD prevention trials with statins shaped current guidelines and provided detailed targets across a range...

journal_title：Current drug targets

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Karagiannis A,Hatzitolios A,Tziomalos K,Ganotakis ES,Liberopoulos EN,Elisaf M

更新日期：2007-03-01 00:00:00

abstract：:The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...

journal_title：Current drug targets

authors： Halford JC,Harrold JA,Lawton CL,Blundell JE

更新日期：2005-03-01 00:00:00

abstract：:Patients with heart failure undergoing non-cardiac surgery still have an unacceptably high morbidity and mortality. Compromised myocardial physiologic reserves in combination with extensive surgery and anesthesia appear to play a crucial role in determining high perioperative morbidity and mortality. Nevertheless, sev...

journal_title：Current drug targets

authors： Morelli A,Ertmer C,Pietropaoli P,Westphal M

更新日期：2009-09-01 00:00:00

abstract：:Alzheimer's disease (AD) has become linked to inflammation and metal biology. Metals (copper, zinc and iron) and inflammatory cytokines are significant factors that increase the onset of sporadic late onset forms of the dementia. The genetic discovery that alleles in the hemochromatosis gene accelerate the onset of di...

journal_title：Current drug targets

authors： Rogers JT,Lahiri DK

更新日期：2004-08-01 00:00:00

abstract：:Mucosal healing has been incorporated in the assessment of treatment efficacy in ulcerative colitis, but in Crohn's disease this concept has only emerged after biological therapies have been evaluated in clinical trials. Systemic steroids don't induce mucosal healing in Crohn's disease, but purine analogues and anti T...

journal_title：Current drug targets

authors： van Assche G,Vermeire S,Rutgeerts P

更新日期：2010-02-01 00:00:00

abstract：:The hedgehog signal transduction network is a critical regulator of metazoan development. Inappropriate activation of this network is implicated in several different cancers, including breast. Genetic evidence in mice as well as molecular biological studies in human cells clearly indicate that activated signaling can ...

journal_title：Current drug targets

authors： Visbal AP,Lewis MT

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：:The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk betw...

journal_title：Current drug targets

authors： Mo YY,Tang H,Miele L

更新日期：2013-09-01 00:00:00

abstract：:Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases. For example, Zinostatin s...

journal_title：Current drug targets

authors： Wang Y,Du H,Zhai G

更新日期：2014-06-01 00:00:00

abstract：:Natural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived fro...

journal_title：Current drug targets

authors： Neal CP,Berry DP,Doucas H,Manson MM,Steward W,Garcea G

更新日期：2006-03-01 00:00:00

abstract：:Methionine aminopeptidases (MetAP) are intracellular metalloproteins responsible for the removal of the initiator NH(2)-terminal methionine from newly synthesized proteins, thereby facilitating their intracellular translocation from the ribosome. Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), whic...

journal_title：Current drug targets

authors： Mauriz JL,Martín-Renedo J,García-Palomo A,Tuñón MJ,González-Gallego J

更新日期：2010-11-01 00:00:00

abstract：:The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...

journal_title：Current drug targets

authors： El Mourabet M,El-Hachem S,Harrison JR,Binion DG

更新日期：2010-02-01 00:00:00

abstract：:The CD6 molecule is a pan T cell marker involved in T cell regulation. Although CD6 expression has been correlated with human autoimmune diseases, only a few therapeutic approaches are exploring this molecule as target in the clinic. The biological functions and mechanisms of actions of CD6 have not been definitively ...

journal_title：Current drug targets

authors： Hernández P,Moreno E,Aira LE,Rodríguez PC

更新日期：2016-01-01 00:00:00

abstract：:Over the past years, there was an explosion in the knowledge of the protein target and molecular mechanism associated with various disease types and in the new research of drugs of natural origin. The key idea is to evaluate bioactive natural products interacting with protein domains of different genetic origin but st...

journal_title：Current drug targets

authors： Braca A,Dal Piaz F,Marzocco S,Autore G,Vassallo A,De Tommasi N

更新日期：2011-03-01 00:00:00

abstract：:Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to ov...

journal_title：Current drug targets

authors： Guiard BP,Lanfumey L,Gardier AM

更新日期：2006-02-01 00:00:00

abstract：:Autophagy is a process the primary role of which is to clear up damaged cellular components such as long-lived proteins and organelles, thus participating in the conservation of different cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism with suppression of bone format...

journal_title：Current drug targets

authors： Wang T,He H,Liu S,Jia C,Fan Z,Zhong C,Yu J,Liu H,He C

更新日期：2019-01-01 00:00:00

abstract：:With the development of modern assisted reproductive technology(ART), the treatment of infertility and the pregnant outcome by ART have been significantly improved. However, implantation failure, particularly the unexplained repeated implantation failure (RIF), is still the unsolved and principal problem to affect the...

journal_title：Current drug targets

authors： Li J,Liang X,Chen Z

更新日期：2013-07-01 00:00:00

abstract：:The development of databases devoted to biological information opened the possibility to integrate, query and analyze biological data obtained from several sources that otherwise would be scattered through the web. Several issues arise in the handling of biological information, mainly due to the diversity of biologica...

journal_title：Current drug targets

authors： Timmers LF,Pauli I,Barcellos GB,Rocha KB,Caceres RA,de Azevedo WF Jr,Soares MB

更新日期：2009-03-01 00:00:00

abstract：:Mannosylphospho dolichol synthase (DPMS) catalyzes the transfer reaction GDP-mannose + Dol-P <--> Dol-P-Man + GDP, a 'key step' in the assembly of lipid-linked oligosaccharide (LLO) and a pre-requisite for asparagine-linked (N-linked) protein glycosylation. DPMS is present from a protozoan parasite to human, and its s...

journal_title：Current drug targets

authors： Baksi K,Tavárez-Pagán JJ,Martínez JA,Banerjee DK

更新日期：2008-04-01 00:00:00

abstract：:It is well documented that elevated levels of PAI-1 in plasma can decrease the fibrinolytic activity in blood with an associated increased risk of thrombus formation. A diverse range of molecules including bacterial lipopolysaccharide (LPS), the inflammatory mediators tumor necrosis factor alpha (TNFalpha) and interle...

journal_title：Current drug targets

authors： Balsara RD,Xu Z,Ploplis VA

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Galanin (GAL) constitutes a family of neuropeptides composed of four peptides: (i) galanin (GAL), (ii) galanin-message associated peptide (GAMP), (iii) galanin-like peptide (GALP), and (iv) alarin. GAL contains 29/30 amino acids, and its biological action occurs through the interactions with its various rece...

journal_title：Current drug targets

authors： Oliveira Volpe CM,Vaz T,Rocha-Silva F,Villar-Delfino PH,Nogueira-Machado JA

更新日期：2020-01-01 00:00:00

abstract：:Imaging of the kidneys can provide valuable information in the work up and management of acute kidney injury. Several different imaging modalities are used to gather information on anatomy of the kidney, to rule out obstruction, differentiate acute kidney injury (AKI) and chronic kidney disease and to obtain informati...

journal_title：Current drug targets

authors： Kalantarinia K

更新日期：2009-12-01 00:00:00

abstract：:Aberrant activation of receptor-tyrosine kinase c-Met/HGF pathway is shown to be associated with cell proliferation, invasion, metastasis and poor-prognosis in several tumor types, including upper gastrointestinal-malignancies. The interaction of c-Met with multiple signalling-pathways involved in tumorigenic-properti...

journal_title：Current drug targets

authors： Gholamin S,Fiuji H,Maftouh M,Mirhafez R,Shandiz FH,Avan A

更新日期：2014-01-01 00:00:00

abstract：:Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytom...

journal_title：Current drug targets

authors： Hasanpourghadi M,Looi CY,Pandurangan AK,Sethi G,Wong WF,Mustafa MR

更新日期：2017-01-01 00:00:00