Abstract:
:Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytometabolites is the Warburg effect. The Warburg effect describes the observation that cancer cells exhibit an increased rate of glycolysis and aberrant redox activity compared to normal cells. This phenomenon promotes further cancer development and progression. Recent observations revealed that some phytometabolites could target metabolic-related enzymes (e.g. Hexokinase, Pyruvate kinase M2, HIF-1) in cancer cells, with little or no harm to normal cells. Since hyper-proliferation of cancer cells is fueled by higher cellular metabolism, phytometabolites targeting these metabolic pathways can create synergistic crosstalk with induced apoptotic pathways and sensitize cancer cells to chemotherapeutic agents. In this review, we discuss phytometabolites that target the Warburg effect and the underlying molecular mechanism that leads to tumor growth suppression.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Hasanpourghadi M,Looi CY,Pandurangan AK,Sethi G,Wong WF,Mustafa MRdoi
10.2174/1389450117666160401124842subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1086-1094issue
9eissn
1389-4501issn
1873-5592pii
CDT-EPUB-74721journal_volume
18pub_type
杂志文章,评审abstract::Acute myeloid leukemia (AML) was the first malignancy for which immunotherapy, in the form of allogeneic hematopoietic stem cell transplantation (allo-HSCT), was integrated into the standard of care. Allo-HSCT however is an imperfect therapy associated with significant morbidity and mortality while offering only incom...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150223120005
更新日期:2017-01-01 00:00:00
abstract::Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/13894501113149990161
更新日期:2013-07-01 00:00:00
abstract::Target discovery using the molecular approach, as opposed to the more traditional systems approach requires the study of the cellular or biological process underlying a condition or disease. The approaches that are employed by the "bench" scientist may be genetic, genomic or proteomic and each has its rightful place i...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450115666141120110323
更新日期:2015-01-01 00:00:00
abstract::Autophagy is a process the primary role of which is to clear up damaged cellular components such as long-lived proteins and organelles, thus participating in the conservation of different cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism with suppression of bone format...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180626120852
更新日期:2019-01-01 00:00:00
abstract::Retinal neovascularization and macular edema are central features of diabetic retinopathy, a major cause of blindness in working age adults. The currently established treatment for diabetic retinopathy targets the vascular pathology by laser photocoagulation. This approach is associated with significant adverse effect...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450054021981
更新日期:2005-06-01 00:00:00
abstract::PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666141219120125
更新日期:2015-01-01 00:00:00
abstract::In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006779025392
更新日期:2006-12-01 00:00:00
abstract::Stroke is one of the leading causes of death and disability worldwide. Because stroke is a multifactorial disease with a short therapeutic window many clinical stroke trials have failed and the only currently approved therapy is thrombolysis. MicroRNAs (miRNA) are endogenously expressed noncoding short single-stranded...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945013804806424
更新日期:2013-01-01 00:00:00
abstract::The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190715102510
更新日期:2019-01-01 00:00:00
abstract::The heterogeneity of proteoglycans (PG)s contributes to their functional diversity. Many functions depend on their ability to bind and modulate the activity of components of the extracellular matrix (ECM). The ability of PGs to interact with other molecules, such as growth factors, is largely determined by the fine st...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450054863662
更新日期:2005-09-01 00:00:00
abstract::Treatment with anti-cancer agents in most cases ultimately results in apoptotic cell death of the target tumor cells. Unfortunately, tumor cells can develop multidrug resistance, e.g., by a reduced propensity to engage in apoptosis by which they become insensitive to multiple chemotherapeutics. Ceramide. the central m...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345452
更新日期:2004-05-01 00:00:00
abstract::Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including brain cells, due to the activity of ferroxidase, which oxidizes ferrous iron following its transfer to the cell surface via the iron transporter, ferroportin, and delivers ferric iron to e...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012802002320
更新日期:2012-08-01 00:00:00
abstract::Molecularly targeting signaling pathways that are involved in the pathogenesis of hematopoietic malignancies may lead to more specific and efficacious therapies. Activation of the RAS signal transduction cascade is a common feature in the molecular pathogenesis of hematologic malignancies. A number of novel agents tar...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779940043
更新日期:2007-02-01 00:00:00
abstract::The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160615074120
更新日期:2017-01-01 00:00:00
abstract::Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141229154500
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170704143529
更新日期:2018-01-01 00:00:00
abstract::Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterize...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033490902
更新日期:2003-08-01 00:00:00
abstract::Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170622092824
更新日期:2019-01-01 00:00:00
abstract::NMDA receptors are a subclass of excitatory, ionotropic L-glutamate neurotransmitter receptors. They are.heteromeric, integral membrane proteins being formed by the assembly of the obligatory NR1 subunit together with modulatory NR2 subunits of which four different types, NR2A-NR2D, have been described. This results i...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450013348461
更新日期:2001-09-01 00:00:00
abstract::The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150531152047
更新日期:2015-01-01 00:00:00
abstract::Breast cancer remains the leading cause of cancer death among females worldwide. It signifies a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Current treatment modalities, including surgery, radiotherapy, and adjuvant chemotherapy or hormone therapy, have not be...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012804545632
更新日期:2012-12-01 00:00:00
abstract::The present article aims to review the literature on the relationship between psychology and inflammatory bowel disease (IBD). In particular, the first section is dedicated to explore the role of psychological factors in the etiopathology of the disease, its development and the efficacy of treatments, while the second...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140627151702
更新日期:2014-01-01 00:00:00
abstract::Immunity is a balanced status with adequate biological defenses to recognize and fight "non-self", as well as adequate tolerance to recognize "self". To maintain this immune homeostasis, a well-organized T cell immune network is required, which in part depends on the well-controlled development of alternative effector...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666161124145641
更新日期:2017-01-01 00:00:00
abstract::The emergency of responsive drug delivery systems has contributed to the reduced cytotoxicity, the improved permeability in tissues and extended circulation time of the active drug. Of particular, enzyme-responsive nanoplatforms have attracted a lot due to the specificity and efficiency of an enzyme-catalyzed reaction...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450122666210114095614
更新日期:2021-01-13 00:00:00
abstract::Recently, the presence of functional interaction between the opioid and cannabinoid system has been shown in various pharmacological responses. Although there is an increasing interest for the feasible therapeutic application of a co-administration of cannabinoids and opioids in some disorders (i.e. to manage pain, to...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010790980367
更新日期:2010-04-01 00:00:00
abstract::Rituximab has demonstrated a major effect in B-cell lymphoma and in a wide range of autoimmune disorders. Unfortunately, the blood-brain-barrier excludes the disorders restricted to the central nervous system (CNS) from the action of rituximab. The progressive phase of multiple sclerosis (MS) is a prototypical CNS aut...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141029234644
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160824161225
更新日期:2017-11-30 00:00:00
abstract::Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450118666170925154428
更新日期:2018-01-01 00:00:00
abstract::Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006778019354
更新日期:2006-08-01 00:00:00
abstract::The liver is essential for the control of glucose and lipid metabolism. Excessive accumulation of fat in the liver disturbs its function and leads to the development of fatty liver diseases. The nonalcoholic fatty liver disease (NAFLD) is a common type of fatty liver disease found in patients who have not consumed sig...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150325231015
更新日期:2015-01-01 00:00:00