Abstract:
:Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed that Cox-2 is over-expressed in cancer and stroma cells during tumor progression, and anti-cancer chemo-radiotherapies induce expression of Cox-2 in cancer cells. Elevated tumor Cox-2 is associated with increased angiogenesis, tumor invasion and promotion of tumor cell resistance to apoptosis. Several experimental and clinical studies have established potent anti-cancer activity of NSAID (Non-steroidal anti-inflammatory drugs) and other Cox-2 inhibitors such as celecoxib. Much attention is being focused on Cox-2 inhibitors as beneficial target for cancer chemotherapy. The mode of action of Cox-2 and its inhibitors remains unclear. Further clinical application needs to be investigated for comprehending Cox-2 biological functions and establishing it as an effective target in cancer therapy.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Khan Z,Khan N,Tiwari RP,Sah NK,Prasad GB,Bisen PSdoi
10.2174/138945011795677764subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1082-93issue
7eissn
1389-4501issn
1873-5592pii
BSP/CDT/E-Pub/00270journal_volume
12pub_type
杂志文章,评审abstract::Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tis...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recogn...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007782151324
更新日期:2007-10-01 00:00:00
abstract::Medical chronobiology deals with the way body's rhythm influences a person's health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190527114529
更新日期:2019-01-01 00:00:00
abstract::Imaging of the kidneys can provide valuable information in the work up and management of acute kidney injury. Several different imaging modalities are used to gather information on anatomy of the kidney, to rule out obstruction, differentiate acute kidney injury (AKI) and chronic kidney disease and to obtain informati...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009789753246
更新日期:2009-12-01 00:00:00
abstract::Family C of G-protein coupled receptors (GPCRs) from humans is constituted by eight metabotropic glutamate (mGlu(1-8)) receptors, two heterodimeric gamma-aminobutyric acid(B) (GABA(B)) receptors, a calcium-sensing receptor (CaR), three taste (T1R) receptors, a promiscuous L-alpha-amino acid receptor (GPRC6A), and five...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779315614
更新日期:2007-01-01 00:00:00
abstract::Atherosclerosis is now widely appreciated to represent a chronic inflammatory reaction of the vascular wall in response to dyslipidemia and endothelial distress involving the inflammatory recruitment of leukocytes and the activation of resident vascular cells. The proliferative response of smooth muscle cells critical...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010791591377
更新日期:2010-08-01 00:00:00
abstract::Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160112112640
更新日期:2016-01-01 00:00:00
abstract::To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012803530260
更新日期:2012-10-01 00:00:00
abstract::Hypertriglyceridaemia is associated with insulin resistance, hypertension, obesity and diabetes. The management of hypertriglyceridaemia and atherogenic dyslipidaemias increasingly involves the use of several drugs for different aspects of the metabolic syndrome. This review highlights the agents for treatment of bloo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787846380
更新日期:2009-04-01 00:00:00
abstract::Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivit...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160310153211
更新日期:2016-01-01 00:00:00
abstract::The rates of erectile dysfunction (ED) in heart failure (HF) are extremely high. Limited capacity of patients with HF to exercise and coronary artery disease are considered to be the main causative mechanisms. Both HF and ED are associated with increased levels of proinflammatory cytokines, such as tumor necrosis fact...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150420145757
更新日期:2015-01-01 00:00:00
abstract::Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666181002143355
更新日期:2019-01-01 00:00:00
abstract::Transport molecules can significantly affect the pharmacodynamics and pharmacokinetics of drugs. An important transport molecule, the 170 kDa P-glycoprotein (Pgp), is constitutively expressed at several organ sites in the human body. Pgp is expressed at the blood-brain barrier, in the kidneys, liver, intestines and in...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006778019264
更新日期:2006-08-01 00:00:00
abstract::Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141229154500
更新日期:2015-01-01 00:00:00
abstract::Galectin-1 (Gal1) was the first identified member of the galectin family of beta-galactosidase-binding proteins. Gal1 has important roles in processes fundamental to growth and survival of an organism, including cell adhesion, cell proliferation and apoptosis, and is expressed in many tissues, including the nervous sy...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450054021864
更新日期:2005-06-01 00:00:00
abstract::Treatment with anti-cancer agents in most cases ultimately results in apoptotic cell death of the target tumor cells. Unfortunately, tumor cells can develop multidrug resistance, e.g., by a reduced propensity to engage in apoptosis by which they become insensitive to multiple chemotherapeutics. Ceramide. the central m...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345452
更新日期:2004-05-01 00:00:00
abstract::Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160217123042
更新日期:2016-01-01 00:00:00
abstract::Phenothiazines and structurally related compounds alongside their other biological activities are able to modulate multidrug resistance (MDR) in tumor cells. The extensive investigations on their MDR modulation effects consist part of the efforts to overcome MDR - the major obstacle in cancer chemotherapy. In this art...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006778226660
更新日期:2006-09-01 00:00:00
abstract::Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011613151031150637
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009788982513
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE:Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhancing the efficacy and improving the safet...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170612095959
更新日期:2018-01-01 00:00:00
abstract::Withdrawn by the publisher. ...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2015-02-12 00:00:00
abstract::Disorders of emotion regulation such as anxiety disorders and depression are common and yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the regulation of emotion. Mice with targeted deletion of genes encoding mediators of the serotonergic transmission have proven to be a powerful to...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314050005
更新日期:2013-05-01 00:00:00
abstract::Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170622092824
更新日期:2019-01-01 00:00:00
abstract::Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), have been identified as potential drug ta...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006776054997
更新日期:2006-03-01 00:00:00
abstract::In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006779025392
更新日期:2006-12-01 00:00:00
abstract::Type 2 diabetes, which has dramatically increased during the last decade normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. Numerous human epidemiological stu...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007781386866
更新日期:2007-08-01 00:00:00
abstract::It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders. Translation of the knowledge gained from CR research in animal models to disease prevention stra...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111007011281
更新日期:2010-10-01 00:00:00
abstract::Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006777435326
更新日期:2006-06-01 00:00:00
abstract::The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450053174550
更新日期:2005-03-01 00:00:00