Abstract:
:Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), have been identified as potential drug targets to treat diverse diseases including cancer and disorders of the immune system. Here we review advances in JAK3 and BTK inhibitors and describe the therapeutic potential of these potent agents in the clinical setting.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Vassilev AO,Tibbles HE,DuMez D,Venkatachalam TK,Uckun FMdoi
10.2174/138945006776054997keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
327-43issue
3eissn
1389-4501issn
1873-5592journal_volume
7pub_type
杂志文章,评审abstract::Atherosclerosis is associated with the increased trans-sialidase activity, which can be detected in the blood plasma of atherosclerosis patients. The likely involvement in the disease pathogenesis made this activity an interesting research subject and the enzyme that may perform such activity was isolated and characte...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190308111619
更新日期:2019-01-01 00:00:00
abstract::Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without damaging normal cells. In recent years, ACP has been pre-clinically used for cancer treatment. Therefore, accurate identification of ACPs will promote their clinical applications. In contrast to labor-intensive experimental techniq...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180801121548
更新日期:2019-01-01 00:00:00
abstract::Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. surplus energy intake over expenditure, is at the core f...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666181217111500
更新日期:2019-01-01 00:00:00
abstract::PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666141219120125
更新日期:2015-01-01 00:00:00
abstract::The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may interfere with gene expression and, in addition to potential therapeutic applications, can be helpful for the investigation of DNA processing, chromatin packag...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345100
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160824161225
更新日期:2017-11-30 00:00:00
abstract::Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative stress makes cancer cells vulnerable to agents that further augment ROS levels, the use of pro-oxidant agents is emerging as an exciting strategy to selectively targ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012802009044
更新日期:2012-07-01 00:00:00
abstract::Five programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for the treatment of locally advanced or metastatic urothelial carcinoma of the bladder and the upper urinary tract. Following the FDA and EMA restrictions of first-line treatment with Atezolizumab and Pembrolizumab in platinum...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200510015216
更新日期:2020-05-09 00:00:00
abstract::The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative pot...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201105152639
更新日期:2020-11-05 00:00:00
abstract::Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450118666170925154428
更新日期:2018-01-01 00:00:00
abstract::Treatment with anti-cancer agents in most cases ultimately results in apoptotic cell death of the target tumor cells. Unfortunately, tumor cells can develop multidrug resistance, e.g., by a reduced propensity to engage in apoptosis by which they become insensitive to multiple chemotherapeutics. Ceramide. the central m...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345452
更新日期:2004-05-01 00:00:00
abstract::At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity. Identifying the i...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007783220605
更新日期:2007-12-01 00:00:00
abstract::Imaging of the kidneys can provide valuable information in the work up and management of acute kidney injury. Several different imaging modalities are used to gather information on anatomy of the kidney, to rule out obstruction, differentiate acute kidney injury (AKI) and chronic kidney disease and to obtain informati...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009789753246
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patie...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666151209123857
更新日期:2017-01-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatmen...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666191112141901
更新日期:2020-01-01 00:00:00
abstract::A major focus has developed for the discovery of proregenerative and neuroprotective therapeutic agents to help the millions of Americans who receive a CNS injury annually. Tribulations have been encountered along the way due to the complicated set of pathways that are initiated post-injury. To target this complicated...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314070003
更新日期:2013-06-01 00:00:00
abstract::Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111009011375
更新日期:2010-11-01 00:00:00
abstract::Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkh...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160208145934
更新日期:2017-01-01 00:00:00
abstract::Lung cancer kills approximately 1.3 million citizens in the world annually. The tyrosine kinase inhibitors (TKI) erlotinib and gefitinib are effective anti-tumor agents especially in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The goal is to increase the potency of TKI in lung cancer p...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150107153609
更新日期:2016-01-01 00:00:00
abstract::The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160615074120
更新日期:2017-01-01 00:00:00
abstract::The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discuss...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043490613
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666161005145143
更新日期:2017-01-01 00:00:00
abstract::The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a growth factor- and cytokine-inducible gene. Concomitant with these pharmaceutical successes is the advances in our understanding of the molecu...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450013348830
更新日期:2001-03-01 00:00:00
abstract::With the development of modern assisted reproductive technology(ART), the treatment of infertility and the pregnant outcome by ART have been significantly improved. However, implantation failure, particularly the unexplained repeated implantation failure (RIF), is still the unsolved and principal problem to affect the...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314080006
更新日期:2013-07-01 00:00:00
abstract::Efforts to interfere with the initiation and promotion of breast and other cancers by endocrine manipulation are not new. It is of obvious benefit to cancer patients to administer substances that combine minimal general toxicity with maximal oestrogen inhibition. Raloxifene is a relatively recent addition to a group o...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450013348263
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE:Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhancing the efficacy and improving the safet...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170612095959
更新日期:2018-01-01 00:00:00
abstract:AIMS:The aim of this study is to provide an overview of several emerging anti-diabetic molecules. BACKGROUND:Diabetes is a complex metabolic disorder involving the dysregulation of glucose homeostasis at various levels. Insulin, which is produced by β-pancreatic cells, is a chief regulator of glucose metabolism, regul...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666191031104653
更新日期:2020-01-01 00:00:00
abstract::The overuse of antibiotics which exerts the selective pressure for bacterial pathogens has facilitated the spread of antibiotics' resistance. Metallo-β-lactamases (MβLs) are zinc enzymes produced by an increasing number of bacterial pathogens. They can readily cleave carbapenems and most other β-lactams that are mains...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140326094504
更新日期:2014-01-01 00:00:00
abstract::The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150825110658
更新日期:2016-01-01 00:00:00
abstract::The rates of erectile dysfunction (ED) in heart failure (HF) are extremely high. Limited capacity of patients with HF to exercise and coronary artery disease are considered to be the main causative mechanisms. Both HF and ED are associated with increased levels of proinflammatory cytokines, such as tumor necrosis fact...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150420145757
更新日期:2015-01-01 00:00:00