Abstract:
:A major focus has developed for the discovery of proregenerative and neuroprotective therapeutic agents to help the millions of Americans who receive a CNS injury annually. Tribulations have been encountered along the way due to the complicated set of pathways that are initiated post-injury. To target this complicated multifaceted signaling cascade, the most promising therapeutics target multiple pathways involved in the secondary injury cascade, such as neuroinflammation, the generation of ROS and mitochondrial dysfunction. Compelling experimental data demonstrates that mitochondrial dysfunction is a pivotal link in the neuropathological sequelae of brain injury. A group of PPAR agonists, specifically rosiglitazone and pioglitazone, have shown an extreme amount of promise in the realm of drug discovery for CNS injury due to their ability to increase functional recovery and decrease lesion volumes following injury. The therapeutic effects of these PPAR agonists are thought to be a direct result of PPAR activity however new data is arising that shows some of the effects may be independent of PPAR activity, targeting a novel mitochondrial protein called mitoNEET. In this review, a thorough evaluation of the role of PPAR and mitoNEET in rosiglitazone and pioglitazone mediated neuroprotection will be completed in order to shed light on the mechanism of a new possible therapeutic intervention for CNS injury.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Yonutas HM,Sullivan PGdoi
10.2174/1389450111314070003subject
Has Abstractpub_date
2013-06-01 00:00:00pages
733-42issue
7eissn
1389-4501issn
1873-5592pii
CDT-EPUB-20130427-1journal_volume
14pub_type
杂志文章,评审abstract::In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...
journal_title:Current drug targets
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doi:10.2174/138945010791011938
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abstract:BACKGROUND:Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patie...
journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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abstract::While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...
journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Current drug targets
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更新日期:2004-07-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779940070
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abstract::The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...
journal_title:Current drug targets
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更新日期:2010-02-01 00:00:00
abstract::Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::The last 15 years have witnessed a resurgence of the role of surgical options for prevention of ischemic stroke. The landmark randomized trials including NASCET and ECST were published and explored the role of carotid endarterectomy in this regard. Patients with high grade stenosis of the internal carotid artery (> or...
journal_title:Current drug targets
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abstract::Adipose tissue plays an active role in energy balance because it is not only a lipid storing and mobilizing tissue but consists of functionally specialized tissues able to produce heat (in brown adipose tissue) and to produce or release a vast number of so called adipokines or adipocytokines. These consist of polypept...
journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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abstract::The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may interfere with gene expression and, in addition to potential therapeutic applications, can be helpful for the investigation of DNA processing, chromatin packag...
journal_title:Current drug targets
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abstract::Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of...
journal_title:Current drug targets
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journal_title:Current drug targets
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abstract::Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...
journal_title:Current drug targets
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abstract::Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to ov...
journal_title:Current drug targets
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journal_title:Current drug targets
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更新日期:2012-10-01 00:00:00
abstract::Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific frater...
journal_title:Current drug targets
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更新日期:2020-12-30 00:00:00