Abstract:
:Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific fraternity in pharmaceutical potential of natural products in combating cancer. The plants and mushrooms credited with success against angiogenesis and cancer metastasis belong to certain Plants including Catharanthus roseus, Aloe Vera,Annona muricata,Curcuma longa, Withania somnifera, and Berberis and mushrooms such as Agaricus,Antrodia,Ganoderma,Grifolafrondosa,Hericiumerinaceus,Phel-linuslinteus, and Trametesversicolor /Coriolusversicolor. The anti-cancer compounds play a pivotal role as free radical scavenger and reactive oxygen species inducer, mitotic spindle kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoi-somerase inhibitor, apoptosis inducers, and eventually checking cancer invasion, migration and proliferation. The present review updates and focuses on the recent findings of the pharmacologically potential bioactive compounds, their anti-tumor potential, and underlying mechanism of preventing cancer metastasis and angiogenesisin order to raise knowledge for fur-ther investigations to develop cancer therapeutics with no adverse side effects The mounting experimental evidences at pre-clinical and clinical levels from various research groups across the globe, regarding prevention of cancer metastasis by natural products unarguably make it a fast-track research area worth mass attention.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Varghese R,Dalvi YBdoi
10.2174/1389450121999201230204526subject
Has Abstractpub_date
2020-12-30 00:00:00eissn
1389-4501issn
1873-5592pii
CDT-EPUB-112855pub_type
杂志文章abstract::Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. Existing therapies have shown to be insufficient and novel strategies are urgently necessary. New advances in understanding the disease a...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140528151649
更新日期:2015-01-01 00:00:00
abstract::Diabetes is one of the most concerning diseases in modern times. Despite considerable advances in therapeutic management, the prevalence of diabetes and its contribution to death and disability continue to be a major health problem. Diabetic vasculopathies are the leading cause of mortality and morbidity in diabetic p...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180821105544
更新日期:2019-01-01 00:00:00
abstract::Pain is a complex multidimensional concept that facilitates the initiation of the signaling cascade in response to any noxious stimuli. Action potential generation in the peripheral nociceptor terminal and its transmission through various types of nociceptors corresponding to mechanical, chemical or thermal stimuli le...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190131114244
更新日期:2019-01-01 00:00:00
abstract::A group of oxytocinergic neurons originating in the paraventricular nucleus of the hypothalamus and projecting to extrahypothalamic brain areas (e.g. hippocampus, medulla oblongata and spinal cord) control penile erection. Activation of these neurons by dopamine and dopamine agonists, excitatory amino acids (N-methyl-...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033347190
更新日期:2003-01-01 00:00:00
abstract::Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141229154500
更新日期:2015-01-01 00:00:00
abstract::Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666181002143355
更新日期:2019-01-01 00:00:00
abstract::Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Tra...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008786786064
更新日期:2008-11-01 00:00:00
abstract::Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006778019354
更新日期:2006-08-01 00:00:00
abstract::Adenocarcinoma of the prostate is the most common type of cancer, excluding skin cancer, and the second leading cause of cancer death in adult men in the United States. The lifetime risk for developing symptomatic prostate cancer is one in five for an American man. A pivotal step in carcinogenesis is a shift in the ba...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033491118
更新日期:2003-04-01 00:00:00
abstract::Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006777435326
更新日期:2006-06-01 00:00:00
abstract::According to international guidelines, treatment of cervical cancer (CC) consists of surgery in early stages and of chemoradiation in locally advanced disease. Metastatic disease is usually treated with palliative chemotherapeutic regimens, but cytostatic drugs present significant side effects and show limited activit...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141010145547
更新日期:2014-01-01 00:00:00
abstract::The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk betw...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/13894501113149990188
更新日期:2013-09-01 00:00:00
abstract::Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010791170842
更新日期:2010-06-01 00:00:00
abstract::Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tis...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Galanin (GAL) constitutes a family of neuropeptides composed of four peptides: (i) galanin (GAL), (ii) galanin-message associated peptide (GAMP), (iii) galanin-like peptide (GALP), and (iv) alarin. GAL contains 29/30 amino acids, and its biological action occurs through the interactions with its various rece...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200225112055
更新日期:2020-01-01 00:00:00
abstract::Molecularly targeting signaling pathways that are involved in the pathogenesis of hematopoietic malignancies may lead to more specific and efficacious therapies. Activation of the RAS signal transduction cascade is a common feature in the molecular pathogenesis of hematologic malignancies. A number of novel agents tar...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779940043
更新日期:2007-02-01 00:00:00
abstract::Programmed cell death, commonly associated with the term apoptosis, is an integrated intracellular program that plays a critical role in lymphoid tissue homeostasis. Alterations in this highly regulated process is a common feature of most lymphoid malignancies, thus facilitating tumor escape from traditional chemother...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010791320863
更新日期:2010-07-01 00:00:00
abstract::Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450118666170925154428
更新日期:2018-01-01 00:00:00
abstract::Mucosal healing has been incorporated in the assessment of treatment efficacy in ulcerative colitis, but in Crohn's disease this concept has only emerged after biological therapies have been evaluated in clinical trials. Systemic steroids don't induce mucosal healing in Crohn's disease, but purine analogues and anti T...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/138945010790309902
更新日期:2010-02-01 00:00:00
abstract::The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine modulation of inflammatory responses and protection of tissues from injuries. Adenosine exerts its modulatory effects via interaction with G protein-coupled receptors, designated as A(1), A(2A), A(2B) and A(3). In this regard, extrac...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012800564095
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Different clinical studies have given inconsistent results on whether the use of antipsychotics increases the risk of thromboembolism. In this paper, we reviewed all relevant literature to provide suggestions for clinical diagnosis and treatment. METHODS:PubMed, Web of Science, EMBASE, MEDLINE, Cochrane and...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200422084414
更新日期:2020-01-01 00:00:00
abstract::Resveratrol (3,4',5 tri-hydroxystilbene) is a phytoalexin produced in hudge amount in grapevine skin in response to infection by Bothrytis cinerea. This production of resveratrol blocks the proliferation of the pathogen, thereby acting as a natural antibiotic. Numerous studies have reported interesting properties of t...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006776359331
更新日期:2006-04-01 00:00:00
abstract::It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of osteoarthritis. This might be related to continuous mechanical wear and tear and/or result from time/age-related modifications of cartilage matrix components. Also a mere loss of viable cells over ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779940070
更新日期:2007-02-01 00:00:00
abstract::Breast Cancer (BC) is the most common cancer among women and the second cause of female death for cancer. When the tumor is not correctly eradicated, there is a high relapse risk and incidence of metastasis. Breast Cancer Stem Cells (BCSCs) are responsible for initiating tumors and are resistant to current anticancer ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666181122113300
更新日期:2019-01-01 00:00:00
abstract::Thrombus formation at a site of arterial injury (eg, rupture of an atherosclerotic plaque in a carotid artery), a crucial step in the pathogenesis of cerebral ischemia, is initiated by the adhesion of platelets to the arterial wall. In vivo, activated platelets release adenosine diphosphate (ADP), whose binding to the...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010790711987
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009788982513
更新日期:2009-08-01 00:00:00
abstract::Patients with heart failure undergoing non-cardiac surgery still have an unacceptably high morbidity and mortality. Compromised myocardial physiologic reserves in combination with extensive surgery and anesthesia appear to play a crucial role in determining high perioperative morbidity and mortality. Nevertheless, sev...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/138945009789108819
更新日期:2009-09-01 00:00:00
abstract::In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006779025392
更新日期:2006-12-01 00:00:00
abstract::Cell proliferation, differentiation, and survival are regulated by a number of extracellular hormones, growth factors, and cytokines in complex organisms. The transduction of the signals by these factors from the outside to the nucleus often requires the presence of small intracellular proteins (i.e. ras and other sma...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450053765833
更新日期:2005-05-01 00:00:00
abstract::The sphingomyelin (SM) pathway is an ubiquitous and evolutionarily conserved signaling system in which ceramide (CA), generated from SM by the action of various isoforms of sphingomyelinases (SMases) functions as an important second messenger. Recent evidence suggests that branching pathways of sphingolipid metabolism...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450003349272
更新日期:2000-09-01 00:00:00