The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.

abstract：:Histone deacetylases are a class of enzymes that play important roles in post translational modifications of histones by deacetylating the lysine residues as well as interacting with various non-histone proteins. This type of enzymes is closely related to oncogenesis and has been proved to be attractive targets for de...

journal_title：Current drug targets

authors： Li X,Zhang J,Xie Y,Jiang Y,Yingjie Z,Xu W

更新日期：2014-06-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by a combination of clinical features consisted of thrombotic or pregnancy-related events and autoimmune antiphospholipid antibodies. In the 1998 International Consensus Preliminary Criteria, APS is defined by the concomitant presence of these clinical features and labo...

journal_title：Current drug targets

authors： Nishiguchi T,Kobayashi T

更新日期：2005-08-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. Existing therapies have shown to be insufficient and novel strategies are urgently necessary. New advances in understanding the disease a...

journal_title：Current drug targets

authors： Nascimento AV,Bousbaa H,Ferreira D,Sarmento B

更新日期：2015-01-01 00:00:00

abstract：:Measurement of 25-hydroxyvitamin D (25-OHD) is widely used for assessing vitamin D status. There has been a dramatic increase in 25-OHD requests over recent years prompting many laboratories to consider the use of automated immunoassays. To achieve higher throughput, these methods have abandoned the traditional solven...

journal_title：Current drug targets

authors： Carter GD

更新日期：2011-01-01 00:00:00

abstract：:The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative pot...

journal_title：Current drug targets

authors： Mohammadipour HS,Forouzanfar F,Forouzanfar A

更新日期：2020-11-05 00:00:00

abstract：:One approach to identify new drugs with antimicrobial activities is to screen large libraries of molecules directly for their capacity to block the growth of bacterial or fungal monocultures. A more relevant way to assess both a product's efficacy and its potential cytotoxicity is undoubtedly to use an in vivo infecti...

journal_title：Current drug targets

authors： Squiban B,Kurz CL

更新日期：2011-06-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by relatively selective degeneration of dopaminergic neurons in the substantia nigra and loss of dopamine in the striatum. More than 50 epidemiological studies confirmed the low incidence of PD in smokers. Examining the distribution of subtypes of nicotinic acetylcholine recep...

journal_title：Current drug targets

authors： Kawamata J,Suzuki S,Shimohama S

更新日期：2012-05-01 00:00:00

abstract：:Endogenous opioid peptides have been studied extensively as potential therapeutics for the treatment of pain. The major problems of using natural opioid peptides as drug candidates are their poor receptor specificity, metabolic instability and inability to reach the brain after systemic administration. A lot of synthe...

journal_title：Current drug targets

authors： Piekielna J,Perlikowska R,Gach K,Janecka A

更新日期：2013-06-01 00:00:00

abstract：:The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...

journal_title：Current drug targets

authors： Chiozzini C,Toschi E

更新日期：2016-01-01 00:00:00

abstract：:There exists an immediate need to develop novel medications for the treatment of mood disorders such as bipolar disorder and depression. Initial interest in glycogen synthase kinase-3 (GSK-3) as a target for the treatment of mood disorders arose from the finding that the mood stabilizing drug lithium directly inhibite...

journal_title：Current drug targets

authors： Gould TD,Picchini AM,Einat H,Manji HK

更新日期：2006-11-01 00:00:00

abstract：:Aberrant activation of receptor-tyrosine kinase c-Met/HGF pathway is shown to be associated with cell proliferation, invasion, metastasis and poor-prognosis in several tumor types, including upper gastrointestinal-malignancies. The interaction of c-Met with multiple signalling-pathways involved in tumorigenic-properti...

journal_title：Current drug targets

authors： Gholamin S,Fiuji H,Maftouh M,Mirhafez R,Shandiz FH,Avan A

更新日期：2014-01-01 00:00:00

abstract：:Virtual screening for active compounds has become an essential step within the drug development pipeline. The computer based prediction of compound binding modes is one of the most time and cost efficient methods for screening ligand libraries and enrich results of potential drugs. Here we present an overview about cu...

journal_title：Current drug targets

authors： Krüger J,Thiel P,Merelli I,Grunzke R,Gesing S

更新日期：2016-01-01 00:00:00

abstract：:It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheuma...

journal_title：Current drug targets

authors： Morimoto J,Kon S,Matsui Y,Uede T

更新日期：2010-04-01 00:00:00

abstract：:Vascular Disrupting Agents (VDA) are a potential new class of oncology drugs that have garnered attention recently as a number of these agents have entered into Phase 2-3 studies. Currently available data suggest how the subsequent evolution of these agents into clinical practice may proceed, with new therapeutic para...

journal_title：Current drug targets

authors： Spear MA,LoRusso P,Mita A,Mita M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension. OBJECTIVE:Nanotechnology in drug delivery has been evid...

journal_title：Current drug targets

authors： Jain A,Kumari R,Tiwari A,Verma A,Tripathi A,Shrivastava A,Jain SK

更新日期：2018-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a natural protein expressed in a wide range of tissues in our body. It is a promising anti-cancer agent due to its selective killing of cancer cells, rendering normal cells unharmed. However, resistance occurs either intrinsically or develops ove...

journal_title：Current drug targets

authors： Ngai SC

更新日期：2020-01-01 00:00:00

abstract：:5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. The pathophysiological effects of LTs can be modulated by the selective inhibition o...

journal_title：Current drug targets

authors： Anwar Y,Sabir JS,Qureshi MI,Saini KS

更新日期：2014-04-01 00:00:00

abstract：:The most widely used mouse models for atherosclerosis are LDL receptor knockout (KO) mice and apolipoprotein E (apoE) KO mice fed standard chow diets or lipid-supplemented diets. Unfortunately, these do not usually exhibit myocardial infarction or other features of human cardiovascular disease such as occlusive corona...

journal_title：Current drug targets

authors： Braun A,Rigotti A,Trigatti BL

更新日期：2008-03-01 00:00:00

abstract：:According to international guidelines, treatment of cervical cancer (CC) consists of surgery in early stages and of chemoradiation in locally advanced disease. Metastatic disease is usually treated with palliative chemotherapeutic regimens, but cytostatic drugs present significant side effects and show limited activit...

journal_title：Current drug targets

authors： Tomao F,Di Tucci C,Imperiale L,Boccia SM,Marchetti C,Palaia I,Muzii L,Panici PB

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins...

journal_title：Current drug targets

authors： Chowdhury D,Kumar D,Sarma P,Tangutur AD,Bhadra MP

更新日期：2017-11-30 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been pr...

journal_title：Current drug targets

authors： De Luca D,Piastra M,Tosi F,Pulitanò S,Mancino A,Genovese O,Pietrini D,Conti G

更新日期：2012-06-01 00:00:00

abstract：:To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...

journal_title：Current drug targets

authors： Ve T,Gay NJ,Mansell A,Kobe B,Kellie S

更新日期：2012-10-01 00:00:00

abstract：:The understanding of the neurobiological processes leading to major depressive disorder (MDD) is an active field of research in the scientific community. For years, the alteration of monoamine neurotransmission, in particular serotonin (5-HT), has been considered the most significant pathophysiological mechanism of th...

journal_title：Current drug targets

authors： Catena-Dell'Osso M,Rotella F,Dell'Osso A,Fagiolini A,Marazziti D

更新日期：2013-05-01 00:00:00

abstract：:Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids c...

journal_title：Current drug targets

authors： Saffar AS,Ashdown H,Gounni AS

更新日期：2011-04-01 00:00:00

abstract：:Various strategies for the use of zein for controlled drug release have been investigated and reported in the literature, especially engineering strategies for using zein conjugates to enhance oral bioavailability and targeted delivery, which has attracted interest in recent research. Although still limited, the abili...

journal_title：Current drug targets

authors： Tran PH,Tran TT

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The mitochondria may very well determine the final commitment of the cell to death, particularly in times of energy stress. Cancer chemotherapeutics such as the anthracycline doxorubicin perturb mitochondrial structure and function in tumour cells, as evidenced in osteosarcoma, for which doxorubicin is used ...

journal_title：Current drug targets

authors： Armstrong J,Dass CR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin ...

journal_title：Current drug targets

authors： de Paula Gonzaga ALAC,Palmeira VA,Ribeiro TFS,Costa LB,de Sá Rodrigues KE,Simões-E-Silva AC

更新日期：2020-01-01 00:00:00

abstract：:Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...

journal_title：Current drug targets

authors： Yang H,Dou QP

更新日期：2010-06-01 00:00:00

abstract：:The sphingomyelin (SM) pathway is an ubiquitous and evolutionarily conserved signaling system in which ceramide (CA), generated from SM by the action of various isoforms of sphingomyelinases (SMases) functions as an important second messenger. Recent evidence suggests that branching pathways of sphingolipid metabolism...

journal_title：Current drug targets

authors： Claus R,Russwurm S,Meisner M,Kinscherf R,Deigner HP

更新日期：2000-09-01 00:00:00

abstract：:Thrombus formation at a site of arterial injury (eg, rupture of an atherosclerotic plaque in a carotid artery), a crucial step in the pathogenesis of cerebral ischemia, is initiated by the adhesion of platelets to the arterial wall. In vivo, activated platelets release adenosine diphosphate (ADP), whose binding to the...

journal_title：Current drug targets

authors： Giossi A,Pezzini A,Del Zotto E,Volonghi I,Costa P,Ferrari D,Padovani A

更新日期：2010-03-01 00:00:00