ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors.

Abstract:

BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin II and AT1 receptor and the alternative axis composed by ACE2, Angiotensin-(1-7) and Mas receptor, have been investigated in cancer. OBJECTIVE:This review aimed to summarize the pathophysiological role of RAS in cancer, evidence for anti-tumor effects of ACE2/Angiotensin-(1-7)/Mas receptor axis and future therapeutic perspectives for pediatric cancer. METHODS:Pubmed, Scopus and Scielo were searched in regard to RAS molecules in human cancer and pediatric patients. The search terms were "RAS", "ACE", "Angiotensin-(1-7)", "ACE2", "Angiotensin II", "AT1 receptor", "Mas receptor", "Pediatric", "Cancer". RESULTS:Experimental studies have shown that Angiotensin-(1-7) inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer. Clinical trials with Angiotensin-( 1-7) or TXA127, a pharmaceutical grade formulation of the naturally occurring peptide, have reported promising findings, but not enough to recommend medical use in human cancer. In regard to pediatric cancer, only three articles that marginally investigated RAS components were found and none of them evaluated molecules of the alternative RAS axis. CONCLUSION:Despite the potential applicability of Angiotensin-(1-7) in pediatric tumors, the role of this molecule was never tested. Further clinical trials are necessary, also including pediatric patients, to confirm safety and efficiency and to define therapeutic targets.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

de Paula Gonzaga ALAC,Palmeira VA,Ribeiro TFS,Costa LB,de Sá Rodrigues KE,Simões-E-Silva AC

doi

10.2174/1389450121666200210124217

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

892-901

issue

9

eissn

1389-4501

issn

1873-5592

pii

CDT-EPUB-104354

journal_volume

21

pub_type

杂志文章
  • Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfuntion.

    abstract::Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biolo...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450122666210120144921

    authors: Gulcan HO,Orhan IE

    更新日期:2021-01-20 00:00:00

  • Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.

    abstract::Human proteins are subjected to more than 200 known post-translational modifications (PTMs) (e.g., phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation, Nacetylation, and citrullination) and these PTMs can alter protein structure and function with consequent effects on the multitude of pathways...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150202160954

    authors: Witalison EE,Thompson PR,Hofseth LJ

    更新日期:2015-01-01 00:00:00

  • Progress in the Understanding of the Immune Microenvironment and Immunotherapy in Malignant Pleural Mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is a remarkably aggressive thoracic malignancy with a limited survival of only 5-12 months. However, MPM still remains unresponsive to conventional standards of treatment, including pleurectomy and decortication, extrapleural pneumonectomy for resectable disease with or without che...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450121666200719011234

    authors: Cheng L,Li N,Xu XL,Mao WM

    更新日期:2020-01-01 00:00:00

  • The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems.

    abstract::Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666160217123042

    authors: Rutkowska A,Dev KK,Sailer AW

    更新日期:2016-01-01 00:00:00

  • Notch-associated microRNAs in cancer.

    abstract::The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk betw...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/13894501113149990188

    authors: Mo YY,Tang H,Miele L

    更新日期:2013-09-01 00:00:00

  • Unique structural motif supports mannosylphospho dolichol synthase: an important angiogenesis regulator.

    abstract::Mannosylphospho dolichol synthase (DPMS) catalyzes the transfer reaction GDP-mannose + Dol-P <--> Dol-P-Man + GDP, a 'key step' in the assembly of lipid-linked oligosaccharide (LLO) and a pre-requisite for asparagine-linked (N-linked) protein glycosylation. DPMS is present from a protozoan parasite to human, and its s...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/138945008783954916

    authors: Baksi K,Tavárez-Pagán JJ,Martínez JA,Banerjee DK

    更新日期:2008-04-01 00:00:00

  • Transcriptional Regulation of mPGES1 in Cancer: An Alternative Approach to Drug Discovery?

    abstract::Prostaglandins serve as the connecting link between inflammation and cancer. mPGES1, the downstream enzyme in the prostaglandin pathway is considered a better target than COX-2 against the progression of cancer due to the cardiovascular and other complications associated with the inhibition of the latter. Despite the ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666160826093137

    authors: Ramanan M,Doble M

    更新日期:2017-01-01 00:00:00

  • Considering Circadian Pattern of Blood Pressure in the Treatment of Hypertension via Chronotherapy: A Conducive or Maladroit Approach.

    abstract::Medical chronobiology deals with the way body's rhythm influences a person's health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeo...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450120666190527114529

    authors: Das R,Mehta DK

    更新日期:2019-01-01 00:00:00

  • Methionine aminopeptidases as potential targets for treatment of gastrointestinal cancers and other tumours.

    abstract::Methionine aminopeptidases (MetAP) are intracellular metalloproteins responsible for the removal of the initiator NH(2)-terminal methionine from newly synthesized proteins, thereby facilitating their intracellular translocation from the ribosome. Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), whic...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450111009011439

    authors: Mauriz JL,Martín-Renedo J,García-Palomo A,Tuñón MJ,González-Gallego J

    更新日期:2010-11-01 00:00:00

  • NF-kappaB signaling: multiple angles to target OA.

    abstract::In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010791011938

    authors: Marcu KB,Otero M,Olivotto E,Borzi RM,Goldring MB

    更新日期:2010-05-01 00:00:00

  • Osteoarthritis: aging of matrix and cells--going for a remedy.

    abstract::It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of osteoarthritis. This might be related to continuous mechanical wear and tear and/or result from time/age-related modifications of cartilage matrix components. Also a mere loss of viable cells over ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945007779940070

    authors: Aigner T,Haag J,Martin J,Buckwalter J

    更新日期:2007-02-01 00:00:00

  • Is surfactant a promising additive drug in ALI/ARDS-patients?

    abstract::The rationale for surfactant replacement therapy in patients with acute respiratory distress syndrome (ARDS) is to restore the normal composition of the surfactant system, as well as to overcome ongoing inactivation of present surfactant. Indeed, surfactant replacement therapy can normalize the composition of the surf...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450043345399

    authors: Schultz MJ,Kesecioglu J

    更新日期:2004-07-01 00:00:00

  • Tachykinins: role in human gastrointestinal tract physiology and pathology.

    abstract::Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006778019354

    authors: Improta G,Broccardo M

    更新日期:2006-08-01 00:00:00

  • HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions.

    abstract::Despite the success of combined antiretroviral therapy, more than half of HIV-1-infected patients in the USA show HIV-associated neurological and neuropsychiatric deficits. This is accompanied by anatomical and functional alterations in vulnerable brain regions of the mesocorticolimbic and nigrostriatal systems that r...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150531162212

    authors: Hu XT

    更新日期:2016-01-01 00:00:00

  • Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.

    abstract::The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150531152047

    authors: Sartiani L,Romanelli MN,Mugelli A,Cerbai E

    更新日期:2015-01-01 00:00:00

  • Aldose reductase, still a compelling target for diabetic neuropathy.

    abstract::Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945008783431781

    authors: Oates PJ

    更新日期:2008-01-01 00:00:00

  • Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology.

    abstract:BACKGROUND:The Coronavirus Disease 2019 (COVID-19) is becoming the major health issue in recent human history with thousands of deaths and millions of cases worldwide. Newer research and old experience with other corona-viruses highlighted a probable underlying mechanism of disturbance of the renin-angiotensin system (...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450121666201020154033

    authors: Vieira C,Nery L,Martins L,Jabour L,Dias R,Simões E Silva AC

    更新日期:2020-10-20 00:00:00

  • PDZ Structure and Implication in Selective Drug Design against Cystic Fibrosis.

    abstract::PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666141219120125

    authors: Holcomb J,Spellmon N,Trescott L,Sun F,Li C,Yang Z

    更新日期:2015-01-01 00:00:00

  • Circulating tumor cells (CTCs) as a liquid biopsy material and drug target.

    abstract::Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tis...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:

    authors: Cai LL,Ye HM,Zheng LM,Ruan RS,Tzeng CM

    更新日期:2014-01-01 00:00:00

  • Historical observations on the discovery of platelets, platelet function testing and the first antiplatelet agent.

    abstract::An understanding of the historical paths that have lead to our current state of knowledge in the field of platelet studies can be both illuminating and inspiring. Considering that the existence and function of platelets were initially described just barely over 100 years ago it is exciting to recognize how far our kno...

    journal_title:Current drug targets

    pub_type: 历史文章,杂志文章

    doi:10.2174/138945011797635858

    authors: Steinhubl SR

    更新日期:2011-11-01 00:00:00

  • Advances in Inhibitors of FXa.

    abstract::Thromboembolic diseases such as deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI) and ischemic strokes are mainly responsible for people's morbidity and mortality and have severely affected the people's quality of life all over the world. According to WHO statistics, an average of 17 mill...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150518095533

    authors: Guo L,Ma S

    更新日期:2015-01-01 00:00:00

  • Update on statins: hope for osteoporotic fracture healing treatment.

    abstract::Fracture healing is a process of recovering injured bone tissue forms and functions. Osteoporosis can delay the healing process, which contributes to personal suffering and loss of activities. Osteoporosis patients tend to lose bone mass at the metaphyseal region which require treatment to increase bone mass. Postmeno...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/13894501113149990195

    authors: Ibrahim N',Mohamed N,Shuid AN

    更新日期:2013-12-01 00:00:00

  • Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect.

    abstract::The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450120666190402145325

    authors: Wang S,Zhou D,Xu Z,Song J,Qian X,Lv X,Luan J

    更新日期:2019-01-01 00:00:00

  • Insights into the Targeting Potential of Thymoquinone for Therapeutic Intervention Against Triple-negative Breast Cancer.

    abstract:BACKGROUND:Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE:Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhancing the efficacy and improving the safet...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450118666170612095959

    authors: Barkat MA,Harshita,Ahmad J,Khan MA,Beg S,Ahmad FJ

    更新日期:2018-01-01 00:00:00

  • Progress of HDAC inhibitor panobinostat in the treatment of cancer.

    abstract::Histone deacetylases are a class of enzymes that play important roles in post translational modifications of histones by deacetylating the lysine residues as well as interacting with various non-histone proteins. This type of enzymes is closely related to oncogenesis and has been proved to be attractive targets for de...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450115666140306152642

    authors: Li X,Zhang J,Xie Y,Jiang Y,Yingjie Z,Xu W

    更新日期:2014-06-01 00:00:00

  • Colloidal carrier systems for transcutaneous immunization.

    abstract::Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical appl...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945011794751492

    authors: Gupta PN,Vyas SP

    更新日期:2011-04-01 00:00:00

  • Targeting the RAS signaling pathway in malignant hematologic diseases.

    abstract::Molecularly targeting signaling pathways that are involved in the pathogenesis of hematopoietic malignancies may lead to more specific and efficacious therapies. Activation of the RAS signal transduction cascade is a common feature in the molecular pathogenesis of hematologic malignancies. A number of novel agents tar...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945007779940043

    authors: Morgan MA,Ganser A,Reuter CW

    更新日期:2007-02-01 00:00:00

  • Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.

    abstract::Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945008785132394

    authors: Sakane F,Imai S,Kai M,Yasuda S,Kanoh H

    更新日期:2008-08-01 00:00:00

  • Design of Zein Conjugation and Surface Modification for Targeting Drug Delivery.

    abstract::Various strategies for the use of zein for controlled drug release have been investigated and reported in the literature, especially engineering strategies for using zein conjugates to enhance oral bioavailability and targeted delivery, which has attracted interest in recent research. Although still limited, the abili...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450120666190913124629

    authors: Tran PH,Tran TT

    更新日期:2020-01-01 00:00:00

  • Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis.

    abstract::The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450120666190715102510

    authors: Urano T,Suzuki Y,Iwaki T,Sano H,Honkura N,Castellino FJ

    更新日期:2019-01-01 00:00:00