ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors.


BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin II and AT1 receptor and the alternative axis composed by ACE2, Angiotensin-(1-7) and Mas receptor, have been investigated in cancer. OBJECTIVE:This review aimed to summarize the pathophysiological role of RAS in cancer, evidence for anti-tumor effects of ACE2/Angiotensin-(1-7)/Mas receptor axis and future therapeutic perspectives for pediatric cancer. METHODS:Pubmed, Scopus and Scielo were searched in regard to RAS molecules in human cancer and pediatric patients. The search terms were "RAS", "ACE", "Angiotensin-(1-7)", "ACE2", "Angiotensin II", "AT1 receptor", "Mas receptor", "Pediatric", "Cancer". RESULTS:Experimental studies have shown that Angiotensin-(1-7) inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer. Clinical trials with Angiotensin-( 1-7) or TXA127, a pharmaceutical grade formulation of the naturally occurring peptide, have reported promising findings, but not enough to recommend medical use in human cancer. In regard to pediatric cancer, only three articles that marginally investigated RAS components were found and none of them evaluated molecules of the alternative RAS axis. CONCLUSION:Despite the potential applicability of Angiotensin-(1-7) in pediatric tumors, the role of this molecule was never tested. Further clinical trials are necessary, also including pediatric patients, to confirm safety and efficiency and to define therapeutic targets.


Curr Drug Targets


Current drug targets


de Paula Gonzaga ALAC,Palmeira VA,Ribeiro TFS,Costa LB,de Sá Rodrigues KE,Simões-E-Silva AC




Has Abstract


2020-01-01 00:00:00














  • Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice.

    abstract::It is well documented that elevated levels of PAI-1 in plasma can decrease the fibrinolytic activity in blood with an associated increased risk of thrombus formation. A diverse range of molecules including bacterial lipopolysaccharide (LPS), the inflammatory mediators tumor necrosis factor alpha (TNFalpha) and interle...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审


    authors: Balsara RD,Xu Z,Ploplis VA

    更新日期:2007-09-01 00:00:00

  • Recent advances in targeted anti-vasculature therapy: the neuroblastoma model.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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  • Cell death targeting therapies in B lymphoid malignancies.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章


    authors: Gulcan HO,Orhan IE

    更新日期:2021-01-20 00:00:00

  • The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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  • Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy.

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    journal_title:Current drug targets

    pub_type: 杂志文章


    authors: Lou XF,Du YZ,Xu XL

    更新日期:2021-01-13 00:00:00

  • Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    更新日期:2019-01-01 00:00:00

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    journal_title:Current drug targets

    pub_type: 杂志文章


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    journal_title:Current drug targets

    pub_type: 杂志文章


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    更新日期:2015-08-25 00:00:00

  • Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


    authors: Nascimento AV,Bousbaa H,Ferreira D,Sarmento B

    更新日期:2015-01-01 00:00:00

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


    authors: Squiban B,Kurz CL

    更新日期:2011-06-01 00:00:00

  • Sphingolipid metabolism enzymes as targets for anticancer therapy.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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    更新日期:2004-05-01 00:00:00

  • Expression and functions of galectin-1 in sensory and motoneurons.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


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  • Natural Products as Anticancer Agents.

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    journal_title:Current drug targets

    pub_type: 杂志文章


    authors: Varghese R,Dalvi YB

    更新日期:2020-12-30 00:00:00

  • Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


    authors: McBride D,Tang J,Zhang JH

    更新日期:2017-01-01 00:00:00

  • TGF-Beta signaling manipulation as potential therapy for IBD.

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    journal_title:Current drug targets

    pub_type: 杂志文章,评审


    authors: Marafini I,Zorzi F,Codazza S,Pallone F,Monteleone G

    更新日期:2013-11-01 00:00:00