PD-L1 Testing for Urothelial Carcinoma: Interchangeability, Reliability and Future Perspectives.

abstract：:Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling ...

journal_title：Current drug targets

authors： Kononczuk J,Czyzewska U,Moczydlowska J,Surażyński A,Palka J,Miltyk W

更新日期：2015-01-01 00:00:00

abstract：:Measurement of 25-hydroxyvitamin D (25-OHD) is widely used for assessing vitamin D status. There has been a dramatic increase in 25-OHD requests over recent years prompting many laboratories to consider the use of automated immunoassays. To achieve higher throughput, these methods have abandoned the traditional solven...

journal_title：Current drug targets

authors： Carter GD

更新日期：2011-01-01 00:00:00

abstract：:The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...

journal_title：Current drug targets

authors： Sartiani L,Romanelli MN,Mugelli A,Cerbai E

更新日期：2015-01-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a major type of ionotropic glutamate receptor. Many studies have shown that NMDA receptors play a pivotal role in the central nervous system (CNS) under both physiological and pathological conditions. The functional diversity of NMDA receptors can be mainly attributed to the...

journal_title：Current drug targets

authors： Li ST,Ju JG

更新日期：2012-02-01 00:00:00

abstract：:Hypertriglyceridaemia is associated with insulin resistance, hypertension, obesity and diabetes. The management of hypertriglyceridaemia and atherogenic dyslipidaemias increasingly involves the use of several drugs for different aspects of the metabolic syndrome. This review highlights the agents for treatment of bloo...

journal_title：Current drug targets

authors： Viljoen A,Wierzbicki AS

更新日期：2009-04-01 00:00:00

abstract：:Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...

journal_title：Current drug targets

authors： Quarcoo D,Hamelmann E

更新日期：2006-06-01 00:00:00

abstract：:Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterize...

journal_title：Current drug targets

authors： Hoozemans JJ,Veerhuis R,Rozemuller AJ,Eikelenboom P

更新日期：2003-08-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) metabolizes heme to generate carbon monoxide (CO), biliverdin, and iron. Biliverdin is subsequently metabolized to bilirubin by biliverdin reductase. HO-1 has recently emerged as a promising therapeutic target in the treatment of vascular disease. Pharmacological induction or gene transfer of H...

journal_title：Current drug targets

authors： Durante W

更新日期：2010-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:Fluoroquinolones are one of the world's most valuable and popularly used categories of antimicrobial agents. This paper attempts to review the substantial progress of fluoroquinolones from their discovery to black box warning. Antibiotic drug choice will remain difficult in the presence of increasing resistance, but t...

journal_title：Current drug targets

authors： Majalekar PP,Shirote PJ

更新日期：2020-01-01 00:00:00

abstract：:Biomedical science is currently undergoing an epoch-marking transition from its classical phase to the post-genome era. The outstanding success of world-wide genome sequencing efforts, evidenced by the recent publication of the draft of the human genome, together with the completion of several genomes of eukaryotic mo...

journal_title：Current drug targets

authors： Nagl SB

更新日期：2002-10-01 00:00:00

abstract：:Galectin-1 (Gal1) was the first identified member of the galectin family of beta-galactosidase-binding proteins. Gal1 has important roles in processes fundamental to growth and survival of an organism, including cell adhesion, cell proliferation and apoptosis, and is expressed in many tissues, including the nervous sy...

journal_title：Current drug targets

authors： Gaudet AD,Steeves JD,Tetzlaff W,Ramer MS

更新日期：2005-06-01 00:00:00

abstract：:The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...

journal_title：Current drug targets

authors： El Mourabet M,El-Hachem S,Harrison JR,Binion DG

更新日期：2010-02-01 00:00:00

abstract：:The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/beta-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. ...

journal_title：Current drug targets

authors： Qi J,Zhu YQ

更新日期：2008-07-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...

journal_title：Current drug targets

authors： Simonsson B,Hjorth-Hansen H,Bjerrum OW,Porkka K

更新日期：2011-03-01 00:00:00

abstract：:Mucosal healing has been incorporated in the assessment of treatment efficacy in ulcerative colitis, but in Crohn's disease this concept has only emerged after biological therapies have been evaluated in clinical trials. Systemic steroids don't induce mucosal healing in Crohn's disease, but purine analogues and anti T...

journal_title：Current drug targets

authors： van Assche G,Vermeire S,Rutgeerts P

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patie...

journal_title：Current drug targets

authors： McBride D,Tang J,Zhang JH

更新日期：2017-01-01 00:00:00

abstract：:Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivit...

journal_title：Current drug targets

authors： Walsh M,Fritz S,Hake D,Son M,Greve S,Jbara M,Chitta S,Fritz B,Miller A,Bader MK,McCollester J,Binz S,Liew-Spilger A,Thomas S,Crepinsek A,Shariff F,Ploplis V,Castellino FJ

更新日期：2016-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tis...

journal_title：Current drug targets

authors： Cai LL,Ye HM,Zheng LM,Ruan RS,Tzeng CM

更新日期：2014-01-01 00:00:00

abstract：:The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...

journal_title：Current drug targets

authors： Halford JC,Harrold JA,Lawton CL,Blundell JE

更新日期：2005-03-01 00:00:00

abstract：:Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...

journal_title：Current drug targets

authors： Mohamed RMP,Kumar J,Yap E,Mohamed IN,Sidi H,Adam RL,Das S

更新日期：2019-01-01 00:00:00

abstract：:Stroke is one of the leading causes of death and disability worldwide. Because stroke is a multifactorial disease with a short therapeutic window many clinical stroke trials have failed and the only currently approved therapy is thrombolysis. MicroRNAs (miRNA) are endogenously expressed noncoding short single-stranded...

journal_title：Current drug targets

authors： Ouyang YB,Stary CM,Yang GY,Giffard R

更新日期：2013-01-01 00:00:00

abstract：:Aberrant activation of receptor-tyrosine kinase c-Met/HGF pathway is shown to be associated with cell proliferation, invasion, metastasis and poor-prognosis in several tumor types, including upper gastrointestinal-malignancies. The interaction of c-Met with multiple signalling-pathways involved in tumorigenic-properti...

journal_title：Current drug targets

authors： Gholamin S,Fiuji H,Maftouh M,Mirhafez R,Shandiz FH,Avan A

更新日期：2014-01-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a remarkably aggressive thoracic malignancy with a limited survival of only 5-12 months. However, MPM still remains unresponsive to conventional standards of treatment, including pleurectomy and decortication, extrapleural pneumonectomy for resectable disease with or without che...

journal_title：Current drug targets

authors： Cheng L,Li N,Xu XL,Mao WM

更新日期：2020-01-01 00:00:00

abstract：:Due to potential health benefits and the general assumption that natural products are safe, there is an increasing trend in the general population - including pregnant women - to supplement their diet with flavonoid-based food supplements. In addition, preclinical studies aim to prevent developmental adverse effects i...

journal_title：Current drug targets

authors： Barenys M,Masjosthusmann S,Fritsche E

更新日期：2017-01-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been pr...

journal_title：Current drug targets

authors： De Luca D,Piastra M,Tosi F,Pulitanò S,Mancino A,Genovese O,Pietrini D,Conti G

更新日期：2012-06-01 00:00:00

abstract：:Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...

journal_title：Current drug targets

authors： Dhote V,Samundre P,Ganeshpurkar A,Upaganlawar A

更新日期：2020-12-09 00:00:00

abstract：:The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine modulation of inflammatory responses and protection of tissues from injuries. Adenosine exerts its modulatory effects via interaction with G protein-coupled receptors, designated as A(1), A(2A), A(2B) and A(3). In this regard, extrac...

journal_title：Current drug targets

authors： Antonioli L,Colucci R,La Motta C,Tuccori M,Awwad O,Da Settimo F,Blandizzi C,Fornai M

更新日期：2012-06-01 00:00:00

abstract：:Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude the chemotherapic f...

journal_title：Current drug targets

authors： Teodori E,Dei S,Martelli C,Scapecchi S,Gualtieri F

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:It becomes increasingly evident that the SARS-CoV-2 infection is not limited to the respiratory system. In addition to being a target of the virus, the kidney also seems to have a substantial influence on the outcomes of the disease. METHODS:Data was obtained by a comprehensive and non-systematic search in ...

journal_title：Current drug targets

authors： Bitencourt L,Pedrosa AL,de Brito SBCS,Fróes ACF,de Carvalho ST,Fonseca GG,Ferreira GC,Fradico PF,Simões E Silva AC

更新日期：2021-01-01 00:00:00