Abstract:
:Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical application onto the intact skin, has many practical merits compared to injectable routes of administration. It combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. This simple and non-invasive immunization procedure elicits systemic and cell mediated immune responses and therefore, it provides a viable and cost-effective strategy for disease prevention. Various strategies i.e physical, chemical and novel carrier systems can be explored for trancutaneous immunization. Specially designed vaccine carrier systems are attracting immense attention and these could be potential module for non-invasive antigen delivery. The review covers topical delivery consideration in brief followed by an insight into various novel delivery systems for transcutaneous vaccine delivery.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Gupta PN,Vyas SPdoi
10.2174/138945011794751492subject
Has Abstractpub_date
2011-04-01 00:00:00pages
579-97issue
4eissn
1389-4501issn
1873-5592pii
BSP/CDT/E-Pub/00220aaajournal_volume
12pub_type
杂志文章,评审abstract:BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666161005145143
更新日期:2017-01-01 00:00:00
abstract::The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped t...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007780362782
更新日期:2007-04-01 00:00:00
abstract::Efficient drug delivery systems are exceedingly important for novel drug discovery. The evidence-based personalized medicine (EBPM) promises to deliver the right drug at the right time to a right patient as it covers clinicallysignificant genetic predisposition and chronopharmacological aspects of nanotheranostics. Re...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:
更新日期:2014-01-01 00:00:00
abstract::With the development of modern assisted reproductive technology(ART), the treatment of infertility and the pregnant outcome by ART have been significantly improved. However, implantation failure, particularly the unexplained repeated implantation failure (RIF), is still the unsolved and principal problem to affect the...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314080006
更新日期:2013-07-01 00:00:00
abstract::Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006778019354
更新日期:2006-08-01 00:00:00
abstract::While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787122842
更新日期:2009-01-01 00:00:00
abstract::Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and a...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009789577954
更新日期:2009-10-01 00:00:00
abstract::Alzheimer's disease (AD) has become linked to inflammation and metal biology. Metals (copper, zinc and iron) and inflammatory cytokines are significant factors that increase the onset of sporadic late onset forms of the dementia. The genetic discovery that alleles in the hemochromatosis gene accelerate the onset of di...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345272
更新日期:2004-08-01 00:00:00
abstract::Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recogn...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007782151324
更新日期:2007-10-01 00:00:00
abstract::Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160112112640
更新日期:2016-01-01 00:00:00
abstract::FOXO transcription factors control proliferation, apoptosis, differentiation and metabolic processes. Loss of FOXO function has been identified in several human cancers, and results in increased cellular survival and a predisposition to neoplasia, especially in epithelial cancer. FOXO factors are therefore bona fide t...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011796150307
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180115164103
更新日期:2018-01-01 00:00:00
abstract::The last 15 years have witnessed a resurgence of the role of surgical options for prevention of ischemic stroke. The landmark randomized trials including NASCET and ECST were published and explored the role of carotid endarterectomy in this regard. Patients with high grade stenosis of the internal carotid artery (> or...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007781077391
更新日期:2007-07-01 00:00:00
abstract::Saponins are plant glycosides that consist of a steroid, steroid alkaloid or triterpenoid aglycone and one or more sugar chains that are covalently linked by glycosidic binding to the aglycone. Glucose, galactose, glucuronic acid, xylose and rhamnose are commonly bound monosaccharides. Saponins are found in all organs...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787354584
更新日期:2009-02-01 00:00:00
abstract::Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed that Cox-2 is over-expressed in cancer and stroma cells during tumor progression, and anti-cancer chemo-radiotherapies induce expression of Co...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011795677764
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The Coronavirus Disease 2019 (COVID-19) is becoming the major health issue in recent human history with thousands of deaths and millions of cases worldwide. Newer research and old experience with other corona-viruses highlighted a probable underlying mechanism of disturbance of the renin-angiotensin system (...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666201020154033
更新日期:2020-10-20 00:00:00
abstract::The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may interfere with gene expression and, in addition to potential therapeutic applications, can be helpful for the investigation of DNA processing, chromatin packag...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345100
更新日期:2004-11-01 00:00:00
abstract::Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008783431781
更新日期:2008-01-01 00:00:00
abstract::Alzheimer's, a degenerative cause of the brain cells, is called as a progressive neurodegenerative disease and appears to have a heterogeneous etiology with main emphasis on amyloid-cascade and hyperphosphorylated tau-cascade hypotheses, that are directly linked with macromolecules called enzymes such as β- & γ-secret...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180820104723
更新日期:2019-01-01 00:00:00
abstract::Currently, low density lipoprotein cholesterol (LDL-C) levels are the main, if not the only, lipid target in the effort to reduce cardiovascular disease (CVD) morbidity and mortality. Several primary and secondary CVD prevention trials with statins shaped current guidelines and provided detailed targets across a range...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007780058933
更新日期:2007-03-01 00:00:00
abstract::Lung cancer kills approximately 1.3 million citizens in the world annually. The tyrosine kinase inhibitors (TKI) erlotinib and gefitinib are effective anti-tumor agents especially in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The goal is to increase the potency of TKI in lung cancer p...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150107153609
更新日期:2016-01-01 00:00:00
abstract::The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450053174550
更新日期:2005-03-01 00:00:00
abstract::The understanding of the neurobiological processes leading to major depressive disorder (MDD) is an active field of research in the scientific community. For years, the alteration of monoamine neurotransmission, in particular serotonin (5-HT), has been considered the most significant pathophysiological mechanism of th...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/13894501113149990154
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Different clinical studies have given inconsistent results on whether the use of antipsychotics increases the risk of thromboembolism. In this paper, we reviewed all relevant literature to provide suggestions for clinical diagnosis and treatment. METHODS:PubMed, Web of Science, EMBASE, MEDLINE, Cochrane and...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200422084414
更新日期:2020-01-01 00:00:00
abstract::Recent progress in molecular biology has provided application of gene transfer methods in arthritis. Two clinical trails using ex vivo retrovirus mediated delivery of interleukin -1 receptor antagonist gene for rheumatoid arthritis has begun in USA and Germany. However, there are still many issues to be elucidated; on...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033490777
更新日期:2003-11-01 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314060009
更新日期:2013-06-01 00:00:00
abstract::Breast cancer is the most common cancer in women in the United States, with African-American (AA) women showing significantly higher rates than Caucasian-American (CA) women do. The reason for this racial disparity remains unknown, and factors that might be responsible for the differences in incidence and mortality ha...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012804545461
更新日期:2012-12-01 00:00:00
abstract::Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the overproduction of membrane transport proteins that are capable to pump chemotherapeutics, antibiotics, detergents, dyes and organic solvents out of the cell. In Gram-negat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008785747789
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The incidence of inflammatory bowel disease (IBD) continues to rise worldwide and despite the advances on pharmacotherapy, the etiopathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) remains underexplained. In this context, the migratory waves of the last decades created a challenging setting to...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666201119142045
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE:Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhancing the efficacy and improving the safet...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170612095959
更新日期:2018-01-01 00:00:00