Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia.

abstract：OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...

journal_title：Current drug targets

authors： Virgili G,Novielli N,Menchini F,Murro V,Giacomelli G

更新日期：2011-02-01 00:00:00

abstract：:Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. Whi...

journal_title：Current drug targets

authors： Oliveira-Paula GH,Tanus-Santos JE

更新日期：2019-01-01 00:00:00

abstract：:Endogenous opioid peptides have been studied extensively as potential therapeutics for the treatment of pain. The major problems of using natural opioid peptides as drug candidates are their poor receptor specificity, metabolic instability and inability to reach the brain after systemic administration. A lot of synthe...

journal_title：Current drug targets

authors： Piekielna J,Perlikowska R,Gach K,Janecka A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Endometriosis (EMS) is a gynecological disease defined by the translocation and growth of endometrial tissue in other tissues or organs outside the uterus. Its clinical manifestations are dysmenorrhea, irregular menstruation, and even infertility. Although EMS is a benign disease, it has the characteristics ...

journal_title：Current drug targets

authors： Ding L,Yang L,Ren C,Zhang H,Lu J,Wang S,Wu Z,Yang Y

更新日期：2020-01-01 00:00:00

abstract：:Efficient drug delivery systems are exceedingly important for novel drug discovery. The evidence-based personalized medicine (EBPM) promises to deliver the right drug at the right time to a right patient as it covers clinicallysignificant genetic predisposition and chronopharmacological aspects of nanotheranostics. Re...

journal_title：Current drug targets

authors： Sharma S

更新日期：2014-01-01 00:00:00

abstract：:Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...

journal_title：Current drug targets

authors： Lahm A,Yagnik A,Tramontano A,Koch U

更新日期：2002-08-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been pr...

journal_title：Current drug targets

authors： De Luca D,Piastra M,Tosi F,Pulitanò S,Mancino A,Genovese O,Pietrini D,Conti G

更新日期：2012-06-01 00:00:00

abstract：:Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivit...

journal_title：Current drug targets

authors： Walsh M,Fritz S,Hake D,Son M,Greve S,Jbara M,Chitta S,Fritz B,Miller A,Bader MK,McCollester J,Binz S,Liew-Spilger A,Thomas S,Crepinsek A,Shariff F,Ploplis V,Castellino FJ

更新日期：2016-01-01 00:00:00

abstract：:Programmed cell death, commonly associated with the term apoptosis, is an integrated intracellular program that plays a critical role in lymphoid tissue homeostasis. Alterations in this highly regulated process is a common feature of most lymphoid malignancies, thus facilitating tumor escape from traditional chemother...

journal_title：Current drug targets

authors： Saborit-Villarroya I,Roué G,López-Guerra M,Alonso R,Xargay-Torrent S,Rosich L,Colomer D

更新日期：2010-07-01 00:00:00

abstract：:Due to potential health benefits and the general assumption that natural products are safe, there is an increasing trend in the general population - including pregnant women - to supplement their diet with flavonoid-based food supplements. In addition, preclinical studies aim to prevent developmental adverse effects i...

journal_title：Current drug targets

authors： Barenys M,Masjosthusmann S,Fritsche E

更新日期：2017-01-01 00:00:00

abstract：:Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...

journal_title：Current drug targets

authors： Improta G,Broccardo M

更新日期：2006-08-01 00:00:00

abstract：:Dysbiosis has been repeatedly observed in inflammatory bowel disease (IBD) and is now recognized as an essential factor in the gut inflammatory process. IBD is a significant burden to health-care systems, mainly due to treatment-related costs. Available treatments have several limitations: up to 30% of patients are pr...

journal_title：Current drug targets

authors： Zatorski H,Nakov R

更新日期：2020-01-01 00:00:00

abstract：:The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-...

journal_title：Current drug targets

authors： Urano T,Suzuki Y,Iwaki T,Sano H,Honkura N,Castellino FJ

更新日期：2019-01-01 00:00:00

abstract：:Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...

journal_title：Current drug targets

authors： Xiong X,Xu Z,Yang Z,Liu Y,Wang D,Dong M,Parker EJ,Zhu W

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. LITERATURE REVIEW:The localization of Aβ plaques particularly in the cholinergic neuron-rich areas has led to the discovery that Aβ binds...

journal_title：Current drug targets

authors： Farhat SM,Ahmed T

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

journal_title：Current drug targets

authors： De Gaudio AR,Rinaldi S

更新日期：2005-11-01 00:00:00

abstract：:Natural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived fro...

journal_title：Current drug targets

authors： Neal CP,Berry DP,Doucas H,Manson MM,Steward W,Garcea G

更新日期：2006-03-01 00:00:00

abstract：:Epigenetic modifications ensure the maintenance of normal cellular functions, and their dysregulation is frequently found in many disease states, including cancer. Nowadays, the most studied epigenetic dysregulation associated with tumorigenesis, cancer progression and metastasis refers to the variations in DNA methyl...

journal_title：Current drug targets

authors： Lin SQ,Li X

更新日期：2020-01-01 00:00:00

abstract：:Autophagy is a process the primary role of which is to clear up damaged cellular components such as long-lived proteins and organelles, thus participating in the conservation of different cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism with suppression of bone format...

journal_title：Current drug targets

authors： Wang T,He H,Liu S,Jia C,Fan Z,Zhong C,Yu J,Liu H,He C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Recently, there are scientific attempts to discover new drugs in the biotechnology industry in order to treat various diseases including atherosclerosis. OBJECTIVE:The main objective of the present review was to highlight the cellular, molecular biology and inflammatory process related to the atheromatous p...

journal_title：Current drug targets

authors： Thent ZC,Chakraborty C,Mahakkanukrauh P,Nik Ritza Kosai Nik Mahmood N,Rajan R,Das S

更新日期：2017-01-01 00:00:00

abstract：:Hypertriglyceridaemia is associated with insulin resistance, hypertension, obesity and diabetes. The management of hypertriglyceridaemia and atherogenic dyslipidaemias increasingly involves the use of several drugs for different aspects of the metabolic syndrome. This review highlights the agents for treatment of bloo...

journal_title：Current drug targets

authors： Viljoen A,Wierzbicki AS

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：:Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...

journal_title：Current drug targets

authors： Tan JX,Lv H,Wang F,Dao FY,Chen W,Ding H

更新日期：2019-01-01 00:00:00

abstract：:Our aim was to provide a narrative review regarding the prevalence, the associated pathophysiologic pathways and the potential management methods of sexual dysfunction related to ablative surgical techniques for Benign Prostatic Enlargement (BPE). Men suffering from BPE are at high risk of sexual dysfunction due to th...

journal_title：Current drug targets

authors： Mykoniatis I,Renterghem KV,Sokolakis I

更新日期：2021-01-01 00:00:00

abstract：:Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...

journal_title：Current drug targets

authors： Oates PJ

更新日期：2008-01-01 00:00:00

abstract：:Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

journal_title：Current drug targets

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2017-01-01 00:00:00

abstract：:Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesi...

journal_title：Current drug targets

authors： Hebuterne X,Filippi J,Schneider SM

更新日期：2014-01-01 00:00:00

abstract：:Retinal neovascularization and macular edema are central features of diabetic retinopathy, a major cause of blindness in working age adults. The currently established treatment for diabetic retinopathy targets the vascular pathology by laser photocoagulation. This approach is associated with significant adverse effect...

journal_title：Current drug targets

authors： Caldwell RB,Bartoli M,Behzadian MA,El-Remessy AE,Al-Shabrawey M,Platt DH,Liou GI,Caldwell RW

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:The incidence of inflammatory bowel disease (IBD) continues to rise worldwide and despite the advances on pharmacotherapy, the etiopathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) remains underexplained. In this context, the migratory waves of the last decades created a challenging setting to...

journal_title：Current drug targets

authors： Estevinho MM,Lopes DJM,Souto MT,Magro F

更新日期：2020-11-19 00:00:00

abstract：:Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...

journal_title：Current drug targets

authors： Dhote V,Samundre P,Ganeshpurkar A,Upaganlawar A

更新日期：2020-12-09 00:00:00