Abstract:
:Efficient drug delivery systems are exceedingly important for novel drug discovery. The evidence-based personalized medicine (EBPM) promises to deliver the right drug at the right time to a right patient as it covers clinicallysignificant genetic predisposition and chronopharmacological aspects of nanotheranostics. Recently nanotechnology has provided clinically-significant information at the cellular, molecular, and genetic level to facilitate evidence-based personalized treatment. Particularly drug encapsulation in pegylated liposomes has improved pharmacodynamics of cancer, cardiovascular diseases, and neurodegenerative diseases. Long-circulating liposomes and block copolymers concentrate slowly via enhanced permeability and retention (EPR) effect in the solid tumors and are highly significant for the drug delivery in cancer chemotherapeutics. Selective targeting of siRNA and oligonucleotides to tumor cells with a potential to inhibit multi-drug resistant (MDR) malignancies has also shown promise. In addition, implantable drug delivery devices have improved the treatment of several chronic diseases. Recently, microRNA, metallothioneins (MTs), α-synuclein index, and Charnoly body (CB) have emerged as novel drug discovery biomarkers. Hence CB antagonists-loaded ROSscavenging targeted nanoparticles (NPs) may be developed for the treatment of neurodegenerative and cardiovascular diseases. Nonspecific induction of CBs in the hyper-proliferative cells may cause alopecia, gastrointestinal tract (GIT) symptoms, myelosuppression, neurotoxicity, and infertility. Therefore selective CB agonists may be developed to augment cancer stem cell specific CB formation to eradicate MDR malignancies with minimum or no adverse effects. This review highlights recent advances on safe, economical, and effective treatment of neurodegenerative diseases, cardiovascular diseases, and cancer by adopting emerging nanotheranostic strategies to accomplish EBPM.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Sharma Ssubject
Has Abstractpub_date
2014-01-01 00:00:00pages
915-30issue
10eissn
1389-4501issn
1873-5592pii
CDT-EPUB-61959journal_volume
15pub_type
杂志文章,评审abstract::Various strategies for the use of zein for controlled drug release have been investigated and reported in the literature, especially engineering strategies for using zein conjugates to enhance oral bioavailability and targeted delivery, which has attracted interest in recent research. Although still limited, the abili...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666190913124629
更新日期:2020-01-01 00:00:00
abstract::The present article aims to review the literature on the relationship between psychology and inflammatory bowel disease (IBD). In particular, the first section is dedicated to explore the role of psychological factors in the etiopathology of the disease, its development and the efficacy of treatments, while the second...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140627151702
更新日期:2014-01-01 00:00:00
abstract::Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tis...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. Existing therapies have shown to be insufficient and novel strategies are urgently necessary. New advances in understanding the disease a...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140528151649
更新日期:2015-01-01 00:00:00
abstract::The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may interfere with gene expression and, in addition to potential therapeutic applications, can be helpful for the investigation of DNA processing, chromatin packag...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043345100
更新日期:2004-11-01 00:00:00
abstract::Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450118666170925154428
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abstract::Over the past years, there was an explosion in the knowledge of the protein target and molecular mechanism associated with various disease types and in the new research of drugs of natural origin. The key idea is to evaluate bioactive natural products interacting with protein domains of different genetic origin but st...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011794815284
更新日期:2011-03-01 00:00:00
abstract::Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011794815301
更新日期:2011-03-01 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314060009
更新日期:2013-06-01 00:00:00
abstract::While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787122842
更新日期:2009-01-01 00:00:00
abstract::Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity. Conjugation of Ub or UBLs to target proteins is dynamica...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666151209114608
更新日期:2018-01-01 00:00:00
abstract::Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesi...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450115666140930150047
更新日期:2014-01-01 00:00:00
abstract::5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. The pathophysiological effects of LTs can be modulated by the selective inhibition o...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450114666131209110745
更新日期:2014-04-01 00:00:00
abstract::The production of reactive oxygen species is a normal part of cell physiology, but many internal and external stimuli are able to trigger the production of excess levels of oxidants that are potentially damaging. The threat of oxidative damage is particularly significant to DNA, as damaged bases can interfere with rep...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150126111055
更新日期:2016-01-01 00:00:00
abstract::The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160615074120
更新日期:2017-01-01 00:00:00
abstract::The emergency of responsive drug delivery systems has contributed to the reduced cytotoxicity, the improved permeability in tissues and extended circulation time of the active drug. Of particular, enzyme-responsive nanoplatforms have attracted a lot due to the specificity and efficiency of an enzyme-catalyzed reaction...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450122666210114095614
更新日期:2021-01-13 00:00:00
abstract::Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033491109
更新日期:2003-05-01 00:00:00
abstract::Atherosclerosis is associated with the increased trans-sialidase activity, which can be detected in the blood plasma of atherosclerosis patients. The likely involvement in the disease pathogenesis made this activity an interesting research subject and the enzyme that may perform such activity was isolated and characte...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
abstract::Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the overproduction of membrane transport proteins that are capable to pump chemotherapeutics, antibiotics, detergents, dyes and organic solvents out of the cell. In Gram-negat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008785747789
更新日期:2008-09-01 00:00:00
abstract::The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011798184128
更新日期:2011-12-01 00:00:00
abstract::Aberrant activation of receptor-tyrosine kinase c-Met/HGF pathway is shown to be associated with cell proliferation, invasion, metastasis and poor-prognosis in several tumor types, including upper gastrointestinal-malignancies. The interaction of c-Met with multiple signalling-pathways involved in tumorigenic-properti...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141107105456
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009788982513
更新日期:2009-08-01 00:00:00
abstract::The popular use of antioxidative vitamins illustrates the growing awareness of oxidative stress as an important hazard to our health and as an important factor in the ageing process. Superoxide radicals and superoxide-derived reactive oxygen species (ROS) are constantly formed in most cells and tissues. To ensure that...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450110607011505
更新日期:2006-11-01 00:00:00
abstract::Enzymes are proteins that act as biological catalysts to speed up cellular biochemical processes. According to their main Enzyme Commission (EC) numbers, enzymes are divided into six categories: EC-1: oxidoreductase; EC-2: transferase; EC-3: hydrolase; EC-4: lyase; EC-5: isomerase and EC-6: synthetase. Different enzym...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666181002143355
更新日期:2019-01-01 00:00:00
abstract::Medical chronobiology deals with the way body's rhythm influences a person's health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190527114529
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The intracellular multiprotein complex termed the inflammasome functions as a platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain conditions, however, the inflammasome produces non-canonical effects such as induction of cell death, pyroptosis and cell metabolism alteration...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160817103435
更新日期:2017-01-01 00:00:00
abstract::Breast cancer remains the leading cause of cancer death among females worldwide. It signifies a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Current treatment modalities, including surgery, radiotherapy, and adjuvant chemotherapy or hormone therapy, have not be...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012804545632
更新日期:2012-12-01 00:00:00
abstract::Saponins are plant glycosides that consist of a steroid, steroid alkaloid or triterpenoid aglycone and one or more sugar chains that are covalently linked by glycosidic binding to the aglycone. Glucose, galactose, glucuronic acid, xylose and rhamnose are commonly bound monosaccharides. Saponins are found in all organs...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787354584
更新日期:2009-02-01 00:00:00
abstract::Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201209202247
更新日期:2020-12-09 00:00:00
abstract::Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450023347650
更新日期:2002-08-01 00:00:00