Insight into Pain Modulation: Nociceptors Sensitization and Therapeutic Targets.

abstract：:Breast cancer remains the leading cause of cancer death among females worldwide. It signifies a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Current treatment modalities, including surgery, radiotherapy, and adjuvant chemotherapy or hormone therapy, have not be...

journal_title：Current drug targets

authors： Sinha D,Biswas J,Sung B,Aggarwal BB,Bishayee A

更新日期：2012-12-01 00:00:00

abstract：:The sialyltransferase family represents a group of enzymes that transfers sialic acid from its common nucleotide sugar donor, CMP-NeuAc, to the terminal carbohydrates group of various glycoproteins and glycolipids. Cloning of these enzymes from mammalian sources indicated these are all type II membrane proteins with t...

journal_title：Current drug targets

authors： Datta AK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The intracellular multiprotein complex termed the inflammasome functions as a platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain conditions, however, the inflammasome produces non-canonical effects such as induction of cell death, pyroptosis and cell metabolism alteration...

journal_title：Current drug targets

authors： Conley SM,Abais JM,Boini KM,Li PL

更新日期：2017-01-01 00:00:00

abstract：:Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of...

journal_title：Current drug targets

authors： Bruining DH

更新日期：2012-09-01 00:00:00

abstract：:Thrombus formation at a site of arterial injury (eg, rupture of an atherosclerotic plaque in a carotid artery), a crucial step in the pathogenesis of cerebral ischemia, is initiated by the adhesion of platelets to the arterial wall. In vivo, activated platelets release adenosine diphosphate (ADP), whose binding to the...

journal_title：Current drug targets

authors： Giossi A,Pezzini A,Del Zotto E,Volonghi I,Costa P,Ferrari D,Padovani A

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic ...

journal_title：Current drug targets

authors： Kugo H,Moriyama T,Zaima N

更新日期：2018-01-01 00:00:00

abstract：:Currently, low density lipoprotein cholesterol (LDL-C) levels are the main, if not the only, lipid target in the effort to reduce cardiovascular disease (CVD) morbidity and mortality. Several primary and secondary CVD prevention trials with statins shaped current guidelines and provided detailed targets across a range...

journal_title：Current drug targets

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Karagiannis A,Hatzitolios A,Tziomalos K,Ganotakis ES,Liberopoulos EN,Elisaf M

更新日期：2007-03-01 00:00:00

abstract：:The most widely used mouse models for atherosclerosis are LDL receptor knockout (KO) mice and apolipoprotein E (apoE) KO mice fed standard chow diets or lipid-supplemented diets. Unfortunately, these do not usually exhibit myocardial infarction or other features of human cardiovascular disease such as occlusive corona...

journal_title：Current drug targets

authors： Braun A,Rigotti A,Trigatti BL

更新日期：2008-03-01 00:00:00

abstract：:The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative pot...

journal_title：Current drug targets

authors： Mohammadipour HS,Forouzanfar F,Forouzanfar A

更新日期：2020-11-05 00:00:00

abstract：:An understanding of the historical paths that have lead to our current state of knowledge in the field of platelet studies can be both illuminating and inspiring. Considering that the existence and function of platelets were initially described just barely over 100 years ago it is exciting to recognize how far our kno...

journal_title：Current drug targets

authors： Steinhubl SR

更新日期：2011-11-01 00:00:00

abstract：:According to international guidelines, treatment of cervical cancer (CC) consists of surgery in early stages and of chemoradiation in locally advanced disease. Metastatic disease is usually treated with palliative chemotherapeutic regimens, but cytostatic drugs present significant side effects and show limited activit...

journal_title：Current drug targets

authors： Tomao F,Di Tucci C,Imperiale L,Boccia SM,Marchetti C,Palaia I,Muzii L,Panici PB

更新日期：2014-01-01 00:00:00

abstract：:A major focus has developed for the discovery of proregenerative and neuroprotective therapeutic agents to help the millions of Americans who receive a CNS injury annually. Tribulations have been encountered along the way due to the complicated set of pathways that are initiated post-injury. To target this complicated...

journal_title：Current drug targets

authors： Yonutas HM,Sullivan PG

更新日期：2013-06-01 00:00:00

abstract：:In evolutionary terms, mitochondria in apicomplexan parasites appear to be "relicts-in-the-making": they possess the smallest mitochondrial genomes known, encoding only three proteins, and in one genus, Cryptosporidium, the genome is eliminated altogether. Several features of mitochondrial physiology provide validated...

journal_title：Current drug targets

authors： Mather MW,Henry KW,Vaidya AB

更新日期：2007-01-01 00:00:00

abstract：:Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkh...

journal_title：Current drug targets

authors： Velikova N,Wells JM

更新日期：2017-01-01 00:00:00

abstract：:Resveratrol (3,4',5 tri-hydroxystilbene) is a phytoalexin produced in hudge amount in grapevine skin in response to infection by Bothrytis cinerea. This production of resveratrol blocks the proliferation of the pathogen, thereby acting as a natural antibiotic. Numerous studies have reported interesting properties of t...

journal_title：Current drug targets

authors： Delmas D,Lançon A,Colin D,Jannin B,Latruffe N

更新日期：2006-04-01 00:00:00

abstract：:Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...

journal_title：Current drug targets

authors： Oates PJ

更新日期：2008-01-01 00:00:00

abstract：:The sphingomyelin (SM) pathway is an ubiquitous and evolutionarily conserved signaling system in which ceramide (CA), generated from SM by the action of various isoforms of sphingomyelinases (SMases) functions as an important second messenger. Recent evidence suggests that branching pathways of sphingolipid metabolism...

journal_title：Current drug targets

authors： Claus R,Russwurm S,Meisner M,Kinscherf R,Deigner HP

更新日期：2000-09-01 00:00:00

abstract：:The overuse of antibiotics which exerts the selective pressure for bacterial pathogens has facilitated the spread of antibiotics' resistance. Metallo-β-lactamases (MβLs) are zinc enzymes produced by an increasing number of bacterial pathogens. They can readily cleave carbapenems and most other β-lactams that are mains...

journal_title：Current drug targets

authors： Guo Z,Ma S

更新日期：2014-01-01 00:00:00

abstract：:Saponins are plant glycosides that consist of a steroid, steroid alkaloid or triterpenoid aglycone and one or more sugar chains that are covalently linked by glycosidic binding to the aglycone. Glucose, galactose, glucuronic acid, xylose and rhamnose are commonly bound monosaccharides. Saponins are found in all organs...

journal_title：Current drug targets

authors： Fuchs H,Bachran D,Panjideh H,Schellmann N,Weng A,Melzig MF,Sutherland M,Bachran C

更新日期：2009-02-01 00:00:00

abstract：:Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude the chemotherapic f...

journal_title：Current drug targets

authors： Teodori E,Dei S,Martelli C,Scapecchi S,Gualtieri F

更新日期：2006-07-01 00:00:00

abstract：:The use of predictive biomarkers provides potential individualized cancer therapeutic options to prevent therapy failure as well as serious toxicities. Several recent studies showed that predictive and prognostic biomarkers are a notable personalized strategy to improve patients' care in several cancers. Trabectedin (...

journal_title：Current drug targets

authors： Souid S,Aissaoui D,Srairi-Abid N,Essafi-Benkhadir K

更新日期：2020-01-01 00:00:00

abstract：:The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...

journal_title：Current drug targets

authors： Epifano F,Curini M,Marcotullio MC,Genovese S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high concentration. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and ...

journal_title：Current drug targets

authors： Yoshida T,Shakushiro K,Sako K

更新日期：2018-02-08 00:00:00

abstract：:Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...

journal_title：Current drug targets

authors： Kulkarni S,Ghosh SP,Hauer-Jensen M,Kumar KS

更新日期：2010-11-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been pr...

journal_title：Current drug targets

authors： De Luca D,Piastra M,Tosi F,Pulitanò S,Mancino A,Genovese O,Pietrini D,Conti G

更新日期：2012-06-01 00:00:00

abstract：:Androgen and androgen receptor (AR) play a critical role in the development of prostate cancer. Androgen deprivation therapy (ADT) has become the therapeutic mainstay for patients with metastatic prostate cancer. ADT can reduce the serum testosterone level from the normal range between 500 and 600 ng/dl to the castrat...

journal_title：Current drug targets

authors： Hara N,Nishiyama T

更新日期：2014-01-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...

journal_title：Current drug targets

authors： Simonsson B,Hjorth-Hansen H,Bjerrum OW,Porkka K

更新日期：2011-03-01 00:00:00

abstract：:Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical appl...

journal_title：Current drug targets

authors： Gupta PN,Vyas SP

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the ...

journal_title：Current drug targets

authors： Shrivastava S,Gupta A,Kaur CD

更新日期：2020-01-01 00:00:00

abstract：:The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped t...

journal_title：Current drug targets

authors： Aird WC

更新日期：2007-04-01 00:00:00