Reduction of the teratogenic effects of phenytoin by folic acid and a mixture of folic acid, vitamins, and amino acids: a preliminary trial.

abstract：:All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...

journal_title：Epilepsia

authors： McAreavey MJ,Ballinger BR,Fenton GW

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the effect of a new antiseizure drug, retigabine (D-23129; N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid ethyl ester) on low-Mg2+-induced epileptiform discharges in rat in vitro. METHODS:Three types of epileptiform discharges (recurrent short discharges in t...

journal_title：Epilepsia

authors： Armand V,Rundfeldt C,Heinemann U

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Guidelines recommend that encephalopathic critically ill children undergo continuous electroencephalographic (CEEG) monitoring for electrographic seizure (ES) identification and management. However, limited data exist on antiseizure medication (ASM) safety for ES treatment in critically ill children. METHODS...

journal_title：Epilepsia

authors： Fung FW,Jacobwitz M,Vala L,Parikh D,Donnelly M,Xiao R,Topjian AA,Abend NS

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of either standard PHT or fosphenytoin (FPHT), a PHT prodrug. The study was formulated to answer the question whether the time required for FPHT to be converted to PHT in the bloodstream would del...

journal_title：Epilepsia

authors： Walton NY,Uthman BM,El Yafi K,Kim JM,Treiman DM

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:To examine the inhibitory effect of anticonvulsants (AEDs) on carnitine transport by the human placental carnitine transporter. METHODS:Uptake of radiolabeled carnitine by human placental brush-border membrane vesicles was measured in the absence and presence of tiagabine (TGB), vigabatrin (VGB), gabapentin (G...

journal_title：Epilepsia

authors： Wu SP,Shyu MK,Liou HH,Gau CS,Lin CJ

更新日期：2004-03-01 00:00:00

abstract：:Epilepsy is frequently associated with cognitive dysfunction. However, the reasons for this correlation are unclear. Possible influential factors include patient age; duration, frequency, etiology, and type of seizures; hereditary factors; psychosocial issues; and antiepileptic drug (AED) therapy. Whereas many of thes...

journal_title：Epilepsia

authors： Vining EP

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to develop a quantitative framework to estimate the likelihood of multifocal epilepsy based on the number of unifocal seizures observed in the epilepsy monitoring unit (EMU). METHODS:Patient records from the EMU at Massachusetts General Hospital (MGH) from 2012 to 2014 were asse...

journal_title：Epilepsia

authors： Struck AF,Cole AJ,Cash SS,Westover MB

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To estimate the incidence and mortality associated with first unprovoked seizure or newly diagnosed epilepsy in a low-income, predominantly Hispanic community in Northern Manhattan, New York City. METHODS:We performed a population-based study to determine the incidence of first unprovoked seizure or newly diag...

journal_title：Epilepsia

authors： Benn EK,Hauser WA,Shih T,Leary L,Bagiella E,Dayan P,Green R,Andrews H,Thurman DJ,Hesdorffer DC

更新日期：2008-08-01 00:00:00

abstract：:The relationship between dreams and epilepsy is illustrated by two patients whose awake epileptic seizures and recurrent dreams during night sleep had similar content. In both of our cases the EEG showed right anterior temporal spike discharge, suggesting a role for the temporal lobe in the association between dreams ...

journal_title：Epilepsia

authors： Reami DO,Silva DF,Albuquerque M,Campos CJ

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Sudden unexpected death in epilepsy (SUDEP) is a critical issue in epilepsy, and DBA/1 mice are a useful animal model of this devastating epilepsy sequela. The serotonin hypothesis for SUDEP proposes that modifying serotonergic function significantly alters susceptibility to seizure-induced respiratory arrest...

journal_title：Epilepsia

authors： Kommajosyula SP,Faingold CL

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Studies using magnetic resonance imaging have shown that reduced hippocampal volume is associated with a history of febrile seizures, the duration of epilepsy, and the number of generalized tonic-clonic seizures. It is uncertain whether these factors have the same influence on functional as on structural measur...

journal_title：Epilepsia

authors： Theodore WH,Kelley K,Toczek MT,Gaillard WD

更新日期：2004-03-01 00:00:00

abstract：:Status epilepticus can lead to impaired renal function, which has been attributed to complications of myoglobinuria. We confirmed changes in renal function in the absence of myoglobinuria by measuring renal hemodynamics, fluid and electrolyte excretions, and plasma levels of renin and atrial natriuretic peptide (ANP) ...

journal_title：Epilepsia

authors： Perrone BL,Vari RC,Kreisman NR

更新日期：1995-07-01 00:00:00

abstract：PURPOSE:Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. Howev...

journal_title：Epilepsia

authors： Pennell PB,Burdette DE,Ross DA,Henry TR,Albin RL,Sackellares JC,Frey KA

更新日期：1999-01-01 00:00:00

abstract：:The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiep...

journal_title：Epilepsia

authors： Wheless JW,Treiman DM

更新日期：2008-12-01 00:00:00

abstract：:The diagnosis of idiopathic generalized epilepsies (IGEs) is not generally difficult if one follows the clinical and electroencephalogram (EEG) definitions of each subsyndrome that constitutes IGEs. In contrast, symptomatic epilepsies develop based on organic brain lesions and are easily diagnosed by the presence of d...

journal_title：Epilepsia

authors： Oguni H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:There are limited data on the indications for the use of chronic invasive electroencephalography (EEG) monitoring (IEM) for pediatric epilepsy surgery. METHODS:We retrospectively studied 102 children who underwent intracranial monitoring to map critical cortex, localize the epileptogenic region, or resolve d...

journal_title：Epilepsia

authors： Brna P,Duchowny M,Resnick T,Dunoyer C,Bhatia S,Jayakar P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical pictu...

journal_title：Epilepsia

authors： Schilling LP,Kieling RR,Pascoal TA,Kim HI,Lee MC,Kim YH,Paglioli E,Neto PR,Costa JC,Palmini A

更新日期：2013-08-01 00:00:00

abstract：:The ultimate treatment goal in epilepsy therapy is always freedom from seizures with as few treatment adverse effects as possible. If seizures persist with the first monotherapy, alternative monotherapy with another antiepileptic drug (AED) should be considered. Continuing seizures should lead to a reevaluation of dif...

journal_title：Epilepsia

authors： Ben-Menachem E

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Depression is a common comorbidity of epilepsy, and its timely identification in persons with epilepsy is essential. The use of screening tools to detect depression is common in epilepsy, but some scales in current use have not been validated using a gold standard in this population. The present study aims to...

journal_title：Epilepsia

authors： Fiest KM,Patten SB,Wiebe S,Bulloch AG,Maxwell CJ,Jetté N

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. METHODS:Statistical analysis of malformation rate and antiepileptic drug exposure data from the Australian Register of Antiepileptic Drugs in Pregnancy, and from the literature. RE...

journal_title：Epilepsia

authors： Vajda FJ,Hitchcock AA,Graham J,O'Brien TJ,Lander CM,Eadie MJ

更新日期：2010-05-01 00:00:00

abstract：:Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed before 1980 appear to act on sodium channels, gamma-aminobutyric acid type A (GABAA) receptors, or calcium channels. Benzodiazepines and barbiturates enhance GABAA recept...

journal_title：Epilepsia

authors： Macdonald RL,Kelly KM

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant action of a gamma-aminobutyric acid (GABA) uptake inhibitor NNC-711 in two models of cortical epileptogenesis in immature rats. METHODS:Twelve-, 18-, and 25-day-old rat pups with implanted electrodes were used in this study. Epileptogenic foci were elicited by a local application of...

journal_title：Epilepsia

authors： Bernásková K,Slamberová R,Mares P

更新日期：1999-09-01 00:00:00

abstract：:A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal E...

journal_title：Epilepsia

authors： Dhuna A,Pascual-Leone A,Talwar D

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:Patients with gliomas frequently present with seizures, but the factors associated with seizure development are still poorly understood. In this study, we assessed peritumoral synaptic network activity in a glioma animal model and tested the contribution of aberrant glutamate release from gliomas on glioma-asso...

journal_title：Epilepsia

authors： Campbell SL,Buckingham SC,Sontheimer H

更新日期：2012-08-01 00:00:00

abstract：SUMMARY:First-time seizure and status epilepticus during pregnancy have been previously reported as the initial manifestation of intracranial cavernous hemangioma. We report a woman with no history of seizures who presented with refractory status epilepticus at 10 weeks gestation. Cranial MRI revealed a right frontal c...

journal_title：Epilepsia

authors： Aladdin Y,Gross DW

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease. METHODS:A retrospective chart review of all patients with TSC seen between January 2002 and October 2008. Charts were reviewed for a history of infant...

journal_title：Epilepsia

authors： Chu-Shore CJ,Major P,Camposano S,Muzykewicz D,Thiele EA

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Vigabatrin (VGB) and lamotrigine (LTG) are two new antiepileptic drugs (AEDs) with different mechanisms of action for treatment of refractory epilepsies. Previous reports have indicated efficacy of both drugs in a number of epileptic syndromes. METHODS:We compared these new AEDs drugs to determine their respec...

journal_title：Epilepsia

authors： Bélanger S,Coulombe G,Carmant L

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS:From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each d...

journal_title：Epilepsia

authors： Kim JA,Yoon JR,Lee EJ,Lee JS,Kim JT,Kim HD,Kang HC

更新日期：2016-01-01 00:00:00

abstract：:Epilepsy-prone and epilepsy-resistant substrains were selectively bred from a strain of BALB/c mice; audiogenic-sensitive epilepsy-prone animals showed enhanced sensitivity to chemical convulsants. Treatment with pyridoxine (100 mg/L in drinking water) initiated at mating and continued throughout pregnancy and the lif...

journal_title：Epilepsia

authors： Dolina S,Peeling J,Sutherland G,Pillay N,Greenberg A

更新日期：1993-01-01 00:00:00

abstract：:Rufinamide (RUF) is a novel antiepileptic drug considered as second-line therapy in the treatment of Lennox-Gastaut syndrome. Treatment-emergent adverse events (AEs) have consisted mainly of drowsiness, irritability, vomiting, and loss of appetite. RUF is considered as a "weight-neutral" drug. We found clinically sign...

journal_title：Epilepsia

authors： Mourand I,Crespel A,Gelisse P

更新日期：2013-01-01 00:00:00