Exacerbation of partial seizures and onset of nonepileptic myoclonus with carbamazepine.

abstract：PURPOSE:Previous studies have shown that the immunosuppressant cyclosporin A (CsA), a specific blocker of the mitochondrial permeability transition (MPT) pore, can dramatically ameliorate the selective neuronal necrosis resulting from ischemia-reperfusion, traumatic brain injury, and N-methyl-d-aspartate (NMDA)-evoked ...

journal_title：Epilepsia

authors： Santos JB,Schauwecker PE

更新日期：2003-08-01 00:00:00

abstract：:The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

journal_title：Epilepsia

authors： Schramm J

更新日期：2008-08-01 00:00:00

abstract：:A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory result...

journal_title：Epilepsia

authors： Asconapé JJ,Manning KR,Lancman ME

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. Thi...

journal_title：Epilepsia

authors： Huang S,Wu C,Jia Y,Li G,Zhu Z,Lu K,Yang Y,Wang F,Zhu S

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS:Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: p...

journal_title：Epilepsia

authors： Shin DS,Yu W,Sutton A,Calos M,Puil E,Carlen PL

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:The interictal and ictal EEG activity in the basal ganglia in patients with temporal lobe epilepsy were studied during invasive EEG monitoring. METHODS:Eight epilepsy surgery candidates, each with a proven mesiotemporal seizure-onset zone, participated in the study. We used two invasive EEG methods to determin...

journal_title：Epilepsia

authors： Rektor I,Kuba R,Brázdil M

更新日期：2002-03-01 00:00:00

abstract：:Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the...

journal_title：Epilepsia

authors： Bartolomei F,Lagarde S,Wendling F,McGonigal A,Jirsa V,Guye M,Bénar C

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with...

journal_title：Epilepsia

authors： King-Stephens D,Mirro E,Weber PB,Laxer KD,Van Ness PC,Salanova V,Spencer DC,Heck CN,Goldman A,Jobst B,Shields DC,Bergey GK,Eisenschenk S,Worrell GA,Rossi MA,Gross RE,Cole AJ,Sperling MR,Nair DR,Gwinn RP,Park YD,

更新日期：2015-06-01 00:00:00

abstract：:We studied 36 drop seizures in 5 patients with myoclonic astatic epilepsy of early childhood (MAEE) with simultaneous split-screen video recording and polygraph. Sixteen were falling attacks and 20 were either less severe attacks exhibiting only deep head nodding or seizures equivalent to drop attacks in terms of icta...

journal_title：Epilepsia

authors： Oguni H,Fukuyama Y,Imaizumi Y,Uehara T

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the utility of baseline neuropsychological measures and scores from the intracarotid amobarbital procedure (IAP) in the prediction of postoperative memory decline in temporal lobe epilepsy surgery patients. METHODS:Logistic regression analyses were used to determine the rel...

journal_title：Epilepsia

authors： Baxendale S,Thompson P,Harkness W,Duncan J

更新日期：2007-03-01 00:00:00

abstract：:The neurodegenerative disorders Alzheimer's disease (AD) and Parkinson's disease (PD) share in common the neuropathologic loss of locus coeruleus (LC) noradrenergic neurons. In addition, these two neurodegenerative disorders share two symptoms that define these disorders: cognitive impairment and depression. The hippo...

journal_title：Epilepsia

authors： Szot P

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Proton magnetic resonance spectroscopic imaging (1H MRSI) can lateralize the epileptogenic frontal lobe by detecting metabolic ratio abnormalities in frontal lobe epilepsy (FLE). We used 1H MRS to lateralize and localize the epileptogenic focus, and we also sought to characterize further the metabolic abnormali...

journal_title：Epilepsia

authors： Lundbom N,Gaily E,Vuori K,Paetau R,Liukkonen E,Rajapakse JC,Valanne L,Häkkinen AM,Granström ML

更新日期：2001-12-01 00:00:00

abstract：:Epileptic seizures and pseudoseizures in temporal lobe epilepsies were studied from the viewpoint of the hierarchy of consciousness. Twenty-two patients with temporal lobe epilepsies (TLE) who showed true amnesia or impairment of consciousness developing from the dreamy state, even though their actions and movement co...

journal_title：Epilepsia

authors： Oana Y

更新日期：1998-01-01 00:00:00

abstract：:Prolonged seizures of status epilepticus (SE) result from failure of mechanisms of seizure termination or activation of mechanisms that sustain seizures. Reduced γ-aminobutyric acid type A receptor-mediated synaptic transmission contributes to impairment of seizure termination. However, mechanisms that sustain prolong...

journal_title：Epilepsia

authors： Joshi S,Kapur J

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Numerous studies have demonstrated changes in cognitive, memory, and language functioning in adults and adolescents after temporal lobectomy, yet little information is available regarding neuropsychological outcome in preadolescent children. METHODS:We studied pre- and postoperative neuropsychological test res...

journal_title：Epilepsia

authors： Szabó CA,Wyllie E,Stanford LD,Geckler C,Kotagal P,Comair YG,Thornton AE

更新日期：1998-08-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Few data describe the sensitivity of a "Seizure Activity Detection Computer" (SzAC) in childhood video/EEG (VEEG) monitoring, especially for very young children. We examined the accuracy of SzAC in childhood VEEG monitoring in different pediatric age groups. METHODS:We visually analyzed VEEG monitoring samples...

journal_title：Epilepsia

authors： Kim HD,Clancy RR

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS:The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS:Epileptic dis...

journal_title：Epilepsia

authors： Jefferys JG

更新日期：2003-01-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：:We examined the seizure records of 13 patients (nine men and four women, ages 27-50 years) with intractable partial epilepsy, maintained with steady anti-epileptic drug dosages. Patients recorded daily seizure frequency on calendars. Periods of outpatient observation ranged from 99 to 1,710 days and the number of obse...

journal_title：Epilepsia

authors： Balish M,Albert PS,Theodore WH

更新日期：1991-09-01 00:00:00

abstract：:Cytoarchitectural alterations during central nervous system (CNS) development are believed to underlie aberrations in brain morphology that lead to epilepsy. We have recently reported marked reductions in hippocampal and white matter volumes along with relative ventriculomegaly in a rat strain bred to be seizure-prone...

journal_title：Epilepsia

authors： Gilby KL,Crino P,McIntyre DC

更新日期：2007-01-01 00:00:00

abstract：:Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated anim...

journal_title：Epilepsia

authors： Diehl RG,Smialowski A,Gotwo T

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity. METHODS:The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellul...

journal_title：Epilepsia

authors： de Almeida AC,Rodrigues AM,Scorza FA,Cavalheiro EA,Teixeira HZ,Duarte MA,Silveira GA,Arruda EZ

更新日期：2008-11-01 00:00:00

abstract：:Seizure prevalence among school age children residing in a rural western Kentucky area (Hardin County) was determined utilizing a method designed to minimize false positives and to allow estimation of false negatives. The observed prevalence of epilepsy is 5.7/1,000 and of febrile seizures 17/1,000. Because of the hig...

journal_title：Epilepsia

authors： Baumann RJ,Marx MB,Leonidakis MG

更新日期：1978-02-01 00:00:00

abstract：PURPOSE:The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS:Long-Evans hooded rats were treated...

journal_title：Epilepsia

authors： Cortez MA,Cunnane SC,Snead OC 3rd

更新日期：2002-01-01 00:00:00

abstract：:Since it was originally described nearly 70 years ago, insular epilepsy has been increasingly recognized and may explain failures after apparently well-planned operations. We review the history of awareness of the phenomenon, techniques for its assessment, and its surgical management. Insular epilepsy can mimic featur...

journal_title：Epilepsia

authors： Laoprasert P,Ojemann JG,Handler MH

更新日期：2017-04-01 00:00:00

abstract：:The anticonvulsant and motor effects of gabapentin (GBP) were evaluated in rat pups aged 16-17 days. Fourteen-day-old rat pups received an implanted stimulating electrode in the amygdala unilaterally. Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala...

journal_title：Epilepsia

authors： Lado FA,Sperber EF,Moshé SL

更新日期：2001-04-01 00:00:00

abstract：:The kinetic profiles of diazepam (DZP) were investigated in plasma, erythrocytes, and discrete brain areas in the rat, and the effects of valproic acid (VPA), given as sodium valproate, on kinetic parameters were analyzed. The experiments were performed on two groups of rats treated daily for 15 days, the first receiv...

journal_title：Epilepsia

authors： Hariton C,Jadot G,Valli M,Mesdjian E,Mandel P

更新日期：1985-01-01 00:00:00

abstract：:The combination of phenobarbital (PB) and phenytoin (PHT) was recommended for many years for treatment of epilepsy in humans. We tested the effectiveness of the combination in a model of hippocampal seizures termed maximal dentate activation (MDA). Two parameters of MDA were measured: duration and time to onset. Neith...

journal_title：Epilepsia

authors： Stringer JL,Higgins MG

更新日期：1994-01-01 00:00:00

abstract：:We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures (rCPS) that would produce efficacy comparable to that observed for approved adult dosages. A dose-response model related seizure-count data to vigabatrin dosage to identify dosages for pediatric rCPS ...

journal_title：Epilepsia

authors： Nielsen JC,Tolbert D,Patel M,Kowalski KG,Wesche DL

更新日期：2014-12-01 00:00:00