Interaction between anticonvulsants and human placental carnitine transporter.

abstract：AIM:Dedicated magnetic resonance imaging (MRI) protocol can diagnose epileptogenic abnormalities in patients with intractable epilepsy. However, it is not sufficiently sensitive to detect small calcified lesions that may result from infections, tumors, or vascular malformations. This study aims to study the impact of t...

journal_title：Epilepsia

authors： Saini J,Kesavadas C,Thomas B,Kapilamoorthy TR,Gupta AK,Radhakrishnan A,Radhakrishnan K

更新日期：2009-06-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development. METHODS:The experiments were performed in postnatal day 14 (P14), P21, and P35 male Wistar rats. After stereotaxic implantation of hippocampal ...

journal_title：Epilepsia

authors： Mazarati A,Wu J,Shin D,Kwon YS,Sankar R

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To investigate the effects of nitric oxide (NO) on seizure activity observed in brain areas that are remote from a primary epileptic focus. METHODS:Following an injection of kainate (concentration 1 mg/ml, volume 1 microl) in the rat hippocampus, we measured NO synthesis in the contralateral hippocampus and ep...

journal_title：Epilepsia

authors： Yasuda H,Fujii M,Fujisawa H,Ito H,Suzuki M

更新日期：2001-01-01 00:00:00

abstract：:A case-control study of 305 children was done to evaluate the relationship between toxocariasis and seizures and risk factors associated with toxocariasis transmission and seizure onset. A significant association existed between seropositivity for anti-Toxocara canis and seizures (p less than 0.05); the correlation wa...

journal_title：Epilepsia

authors： Arpino C,Gattinara GC,Piergili D,Curatolo P

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Benign partial epilepsy (BPE) in childhood is characterized by the occurrence of interictal stereotyped focal spikes with variable localization in the EEG. Children with BPE often exhibit neuropsychological deficits. It is unclear whether a correlation exists between these deficits and the localization of spike...

journal_title：Epilepsia

authors： Wolff M,Weiskopf N,Serra E,Preissl H,Birbaumer N,Kraegeloh-Mann I

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:We studied temporal changes of brain sodium and apparent diffusion coefficient (ADC) in a temporal lobe epilepsy (TLE) rat model using kainic acid (KA). METHODS:In situ three-dimensional 23Na magnetic resonance imaging (MRI) and proton diffusion-weighted imaging (DWI) were used. KA at a dose of 10 mg/kg body w...

journal_title：Epilepsia

authors： Wang Y,Majors A,Najm I,Xue M,Comair Y,Modic M,Ng TC

更新日期：1996-10-01 00:00:00

abstract：:Seizures in the neonate are often considered a form of status epilepticus (SE) because they are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be associated with significant morbidity and mortality. Despite their clinical importance, there is still no clear understanding of how sei...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1999-01-01 00:00:00

abstract：:Interictal discharges can occur silently without apparent simultaneous clinical manifestations. Nevertheless, formal testing during electroencephalographic (EEG) recording may demonstrate transitory cognitive impairment (TCI). The probability of demonstrating TCI is related to the nature of the test employed and the t...

journal_title：Epilepsia

authors： Binnie CD,Marston D

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The role of the superior colliculus (SC) in seizure expression is controversial and appears to be dependent upon the epilepsy model. This study shows the effect of disconnection between SC deep layers and adjacent tissues in the expression of acute and kindling seizures. METHODS:Subcollicular transections, abl...

journal_title：Epilepsia

authors： Doretto MC,Cortes-de-Oliveira JA,Rossetti F,Garcia-Cairasco N

更新日期：2009-12-01 00:00:00

abstract：:Studies from several countries have reported that fewer people with epilepsy marry, but the reasons for this are not clear. In the present investigation, 178 adults with epilepsy were divided into married, separated/divorced, and never married groups. The never married group was subdivided into persons living in depen...

journal_title：Epilepsia

authors： Batzel LW,Dodrill CB

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:In 1992, the International Lamotrigine Pregnancy Registry was initiated to enroll prospectively and to monitor pregnancies exposed to lamotrigine (LTG) for the occurrence of major birth defects. This study presents results as of September 2001 on 168 outcomes exposed to LTG monotherapy and 166 outcomes after pr...

journal_title：Epilepsia

authors： Tennis P,Eldridge RR,International Lamotrigine Pregnancy Registry Scientific Advisory Committee.

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Many antiseizure drugs (ASDs) act on voltage-dependent sodium channels, and the molecular basis of these effects is well established. In contrast, how ASDs act on the level of neuronal networks is much less understood. METHODS:In the present study, we determined the effects of eslicarbazepine (S-Lic) on diff...

journal_title：Epilepsia

authors： Schmidt S,Pothmann L,Müller-Komorowska D,Opitz T,Soares da Silva P,Beck H

更新日期：2021-01-16 00:00:00

abstract：PURPOSE:To examine which variables available early in the course of childhood epilepsy are associated with a poor short-term outcome and to develop models to predict such an outcome. METHODS:We prospectively followed up 466 children with newly diagnosed epilepsy for 2 years. Variables were collected at intake and afte...

journal_title：Epilepsia

authors： Arts WF,Geerts AT,Brouwer OF,Boudewyn Peters AC,Stroink H,van Donselaar CA

更新日期：1999-06-01 00:00:00

abstract：:The development of the Neuropsychological Battery for Epilepsy is presented. The tests are designed to be helpful in the evaluation of adult epileptics. The battery consists of General Measures which include tests in the areas of intellectual functioning, emotional status, and lateral dominance. The development of a s...

journal_title：Epilepsia

authors： Dodrill CB

更新日期：1978-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...

journal_title：Epilepsia

authors： Leonhardt G,de Greiff A,Weber J,Ludwig T,Wiedemayer H,Forsting M,Hufnagel A

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Recent reports define temporal lobe epilepsy with amygdala enlargement (TLE-AE) as a distinct electroclinical syndrome comparable to TLE with hippocampal sclerosis. In this retrospective observational study, we present the largest consecutive series of patients with new-onset TLE-AE to date and describe clini...

journal_title：Epilepsia

authors： Malter MP,Widman G,Galldiks N,Stoecker W,Helmstaedter C,Elger CE,Wagner J

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Proton magnetic resonance spectroscopy (MRS) was used to identify specific in situ metabolic markers for seizures and seizure-induced neuronal damage. Kainic acid (KA)-induced seizures lead to histopathologic changes in rat brain. The protective effect of cycloheximide treatment against neuronal damage caused b...

journal_title：Epilepsia

authors： Najm IM,Wang Y,Shedid D,Lüders HO,Ng TC,Comair YG

更新日期：1998-03-01 00:00:00

abstract：:We examined the relationship between clinical characteristics and EEG classification in all children with febrile seizures examined at the University Pediatric Clinic, Skopje, Yugoslavia between 1982 and 1984. This is the only facility in Macedonia providing EEG or neurologic consultation for children. EEGs were class...

journal_title：Epilepsia

authors： Sofijanov N,Emoto S,Kuturec M,Dukovski M,Duma F,Ellenberg JH,Hirtz DG,Nelson KB

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Benign epilepsy with centrotemporal spikes (BECTS) is associated with mild cognitive deficits, especially language impairment. This study aimed to clarify whether children with BECTS with left- or right-hemispheric, or bilateral focus have specific neuropsychological language deficits when compared to healthy c...

journal_title：Epilepsia

authors： Datta AN,Oser N,Bauder F,Maier O,Martin F,Ramelli GP,Steinlin M,Weber P,Penner IK

更新日期：2013-03-01 00:00:00

abstract：:We assessed the effects of phenytoin (PHT) overdosage on ballistic arm abduction movements in nine epileptic patients receiving long-term PHT treatment. During the overdosage period, all but one showed clinical abnormalities referable to impaired cerebellar function; one also had slowness of movement. Ballistic moveme...

journal_title：Epilepsia

authors： Benvenuti F,Bandinelli S,Mencarelli MA,Lunardelli ML,Campostrini R,Zaccara G,Pantaleo T

更新日期：1992-03-01 00:00:00

abstract：:Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...

journal_title：Epilepsia

authors： Rodin EA,Katz M,Lennox K

更新日期：1976-09-01 00:00:00

abstract：:We set out to review the extent to which molecular karyotyping has overtaken conventional cytogenetics in applications related to epilepsy. Multiplex ligase-dependent probe amplification (MLPA) targeted to predetermined regions such as SCN1A and KCNQ2 has been effectively applied over the last half a decade, and oligo...

journal_title：Epilepsia

authors： Mulley JC,Mefford HC

更新日期：2011-03-01 00:00:00

abstract：:A number of factors have contributed to improvements in the care of epilepsy during the past decade, including the International League Against Epilepsy classifications, therapeutic antiepileptic drug (AED) monitoring and the concept of monotherapy, new AEDs with novel mechanisms of action, and new insights into etiol...

journal_title：Epilepsia

authors： Gram L

更新日期：1995-01-01 00:00:00

abstract：:The distribution of seizure types was investigated in an epidemiological survey of 1,220 patients over 15 years of age. Classification of clinically dominant seizure type according to the International Classification of Epileptic Seizures (ICES) was possible in 1,005 cases (82.5%). Fifty-six percent of patients had pa...

journal_title：Epilepsia

authors： Keränen T,Sillanpää M,Riekkinen PJ

更新日期：1988-01-01 00:00:00

abstract：:We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures (rCPS) that would produce efficacy comparable to that observed for approved adult dosages. A dose-response model related seizure-count data to vigabatrin dosage to identify dosages for pediatric rCPS ...

journal_title：Epilepsia

authors： Nielsen JC,Tolbert D,Patel M,Kowalski KG,Wesche DL

更新日期：2014-12-01 00:00:00

abstract：:The current neurologic literature tends to equate the term "epilepsy" with "epileptic seizures" and regards the condition mainly as a symptom of several different neurologic disorders. This has led to the creation of a great variety of "epilepsies" and a proposal to establish an International Classification of Epileps...

journal_title：Epilepsia

authors： Rodin E

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical pictu...

journal_title：Epilepsia

authors： Schilling LP,Kieling RR,Pascoal TA,Kim HI,Lee MC,Kim YH,Paglioli E,Neto PR,Costa JC,Palmini A

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:We sought to investigate the anticonvulsant activity of the new antiepileptic drug (AED), valrocemide or TV1901 (VGD) in various animal (rodent) models of human epilepsy to determine its anticonvulsant profile and safety margin. METHODS:VGD was administered intraperitoneally to CF no. 1 mice and orally or intr...

journal_title：Epilepsia

authors： Isoherranen N,Woodhead JH,White HS,Bialer M

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:We determined the prevalence of oral disorders and the dental treatment needs of outpatients with epilepsy. METHODS:A questionnaire was administered to 56 consecutive patients (35 males, 21 females) presenting to an outpatient clinic. All patients underwent dental examinations. The clinical and diagnostic feat...

journal_title：Epilepsia

authors： Ogunbodede EO,Adamolekun B,Akintomide AO

更新日期：1998-06-01 00:00:00