Abstract:
PURPOSE:We studied temporal changes of brain sodium and apparent diffusion coefficient (ADC) in a temporal lobe epilepsy (TLE) rat model using kainic acid (KA). METHODS:In situ three-dimensional 23Na magnetic resonance imaging (MRI) and proton diffusion-weighted imaging (DWI) were used. KA at a dose of 10 mg/kg body weight and 12 adult Sprague Dawley rats weighing 228-318 g (268 +/- 25 g) were used. RESULTS:Twenty-four hours after KA injection, magnetic resonance (MR) visible sodium levels increased in both the pyriform cortex (+90%) and amygdala (+68%) and increased insignificantly in the hippocampus (+18%) and caudate-putamen (12%). The ADC in the pyriform cortex showed a -9% decrease at 5 h postictally, reaching -30% at 24 h, whereas in the amygdala decreases were -8 and -26% respectively. A significant decrease in ADC (-7%) in the hippocampus was also observed 24 h postically. Seven days later, sodium increases persisted, whereas ADC returned to normal level. CONCLUSIONS:The increase in MR visible sodium, associated with the decrease in ADC is consistent with the hypothesis that sequential seizures caused an increase in sodium influx and perturbation of membrane ion homeostasis, which eventually evolved into an irreversible phase of cellular edema, with increased MR visible intracellular sodium and decreased ADC. Return of ADC to near-control level and persistent high sodium level at 7 days may be explained by the increase in extracellular space and tissue necrosis.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Wang Y,Majors A,Najm I,Xue M,Comair Y,Modic M,Ng TCdoi
10.1111/j.1528-1157.1996.tb00539.xsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
1000-6issue
10eissn
0013-9580issn
1528-1167journal_volume
37pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract:PURPOSE:Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET. METH...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01186.x
更新日期:2007-09-01 00:00:00
abstract::People with epilepsy (PWEs) are often advised against participating in sports and exercise, mostly because of fear, overprotection, and ignorance about the specific benefits and risks associated with such activities. Available evidence suggests that physical exercise and active participation in sports may favorably af...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13261
更新日期:2016-01-01 00:00:00
abstract::Using a randomized parallel group study design, we compared the cognit ive effects of carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) in children with epilepsy. Seventy-three children with newly diagnosed epilepsy were tested with the Wechsler Intelligence Scale for Children-Revised (WISC-R), Bender-Gesta...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1528-1157.1996.tb00516.x
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Although the number of antiepileptic drugs (AEDs) is increasing, none displays neuroprotective or antiepileptogenic properties that could prevent status epilepticus (SE)-induced drug-resistant epilepsy. Ketogenic diet (KD) and calorie restriction (CR) are proposed as alternative treatments in epilepsy. Our goal...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2010.02667.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The need for alternative pharmacologic strategies in treatment of epilepsies is pressing for about 30% of patients with epilepsy who do not experience satisfactory seizure control with present treatments. In temporal lobe epilepsy (TLE) even up to 80% of patients are pharmacoresistant, and surgical resection ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13360
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To identify and define clinical and behavioral features of patients with adult-onset idiopathic generalized epilepsy (IGE). METHODS:We reviewed the charts of 313 IGE patients at the NYU Comprehensive Epilepsy Center over the past 5 years to identify patients with adult onset (18 years old or older). We exclude...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2001.14901.x
更新日期:2001-11-01 00:00:00
abstract::Polypharmacy is a widely employed treatment strategy in epilepsy, particularly for individuals with poorly controlled seizures. Drug combinations should be carefully considered to minimize the potential for unfavorable interactions. Older-generation antiepileptic drugs (AEDs) are well known for their pharmacokinetic i...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2007.00983.x
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:Epilepsy is the most common serious neurologic disease, and current treatments are ineffective for journal_title:Epilepsia pub_type: 杂志文章 doi:10.1111/j.1528-1167.2006.00540.x 更新日期:2006-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate whether the nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC). The Pf is one of the main ascending projections of the SC, the disinhibition of which has been shown to suppress seizures in d...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.30304.x
更新日期:2005-01-01 00:00:00
abstract::The use of guidelines to prevent the broadcast of epileptogenic television program content has reduced the incidence of seizures in Britain and Japan. Epileptogenic content includes both flicker and patterns. The guidelines for flicker were developed on the basis of a model that related stimulus parameters to the prop...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2005.01405.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Organophosphates (OPs) are commonly used insecticides for agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs result in overstimulation of the cholinergic system and lead to status epilepticus (SE), a life-threatening condition that is often resistant to treatment. SE is ass...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12838
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To investigate further the membrane properties and postsynaptic potentials of the CA3 pyramidal cells in mice that display spontaneous seizures because of a targeted deletion of the Kcna1 potassium channel gene (encoding the Kv1.1 protein subunit). METHODS:Intracellular recordings were obtained from CA3 pyrami...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2003.44602.x
更新日期:2003-12-01 00:00:00
abstract::Fetal heart rate (FHR) characteristics of fetuses exposed and not exposed to antiepileptic drugs (AEDs) were studied. FHR is considered to reflect central nervous system (CNS) integrity. Three intervals during pregnancy were investigated: 20, 32, and 38 weeks. At 32 and 38 weeks, FHR was studied in relation to quiet (...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1992.tb02353.x
更新日期:1992-07-01 00:00:00
abstract:PURPOSE:Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuro...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03267.x
更新日期:2011-12-01 00:00:00
abstract::A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. The questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and the prevalenc...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2011.03002.x
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD. METHODS:We reviewed the data of 28 patients with temporal lobe epilepsy who underwent surgery with pathologically verifi...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2003.16703.x
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of antiepileptic drugs (AEDs; oxcarbazepine [OXC], levetiracetam [LEV], and lamotrigine [LTG]) on semen quality, sexual function, and sex hormones in male adults with epilepsy. METHODS:Individual treatment with OXC, LEV, or LTG was randomly assigned to 38 newly diagnosed male adult...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.14450
更新日期:2018-07-01 00:00:00
abstract::The Asia-Oceanian region is the most populous region in the world. Although there has been substantial economic development and improvement in health services in recent years, epilepsy remains generally an underrecognized and understudied condition. To help promote research in the region, the Commission on Asian and O...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12957
更新日期:2015-05-01 00:00:00
abstract::The mechanism by which animals develop tolerance to the antiepileptic effects of the carbonic anhydrase (CA) inhibitor, acetazolamide, was explored using a quantitative immunocytochemical method. Cerebral cortex sections of DBA/2J mice susceptible to audiogenic seizures and of C57BL/6J nonsusceptible mice were stained...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1986.tb03576.x
更新日期:1986-09-01 00:00:00
abstract::5-Hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by high-performance liquid chromatography (HPLC) in lumbar cerebrospinal fluid (CSF) obtained from febrile children subdivided according to the presence or absence of convulsions. Lumbar puncture was made either early (mean time 2 h) or late...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.1990.tb06303.x
更新日期:1990-03-01 00:00:00
abstract::Estrogens have previously been reported to be proconvulsants in adult animals. This study evaluated the effects of acute, high-dose estrogen administration on rate of kindling in immature rats. No significant differences in rate of kindling between the estrogen-treated rats and controls were noted. This study, using t...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1986.tb03580.x
更新日期:1986-09-01 00:00:00
abstract::The fragile X mental retardation 1 gene (Fmr1) is polymorphic for CGG trinucleotide repeat number in the 5'-untranslated region, with repeat lengths <45 associated with typical development and repeat lengths >200 resulting in hypermethylation and transcriptional silencing of the gene and mental retardation in the frag...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2012.03486.x
更新日期:2012-06-01 00:00:00
abstract::In the first part of this essay, the "common wisdom" about Putnam and Merritt's contributions to the treatment of epilepsy was summarized (Rowland, 1982). Based on the history that has been presented here, how true are these "wisdoms"? Putnam and Merritt did devise "a simple and reliable method to test drugs of antico...
journal_title:Epilepsia
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1528-1157.1986.tb05743.x
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patter...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13742
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Interictal spikes are a characteristic feature of invasive electroencephalography (EEG) recordings in children with refractory epilepsy. Spikes frequently co-occur across multiple brain regions with discernable latencies, suggesting that spikes can propagate through distributed neural networks. The purpose of...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.14720
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13622
更新日期:2017-01-01 00:00:00
abstract::The effect od dipropylacetic acid (DPA; Depakine) on the bemegride-induced convulsive threshold was investigated in alert cats. Forty-five min after DPA 200 mg/kg, s.c., no significant effect was obtained; 5 min after the same dose iv., protection from bemegride-induced seizures was pronounced. DPA did not decrease fo...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1975.tb04724.x
更新日期:1975-03-01 00:00:00
abstract::The practice of epileptology at a molecular level, where gene products are identified by gene mapping, will soon be possible for a growing number of epilepsies. Juvenile myoclonic epilepsy (JME) is the first of such epilepsies to be mapped to a chromosome, namely chromosome 6p21.3. Family studies of 68 JME probands fr...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1157.1989.tb05835.x
更新日期:1989-01-01 00:00:00
abstract::Severe Myoclonic Epilepsy in infancy (SMEI, or Dravet syndrome) is a drug-resistant epilepsy that occurs in the first year of life of previously healthy children. The main clinical features are prolonged and repeated febrile and afebrile generalized or unilateral convulsive seizures. In the course of the epilepsy, cog...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00688.x
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To explore the correlations between treatment modalities and selected disease parameters with outcome in febrile infection-related epilepsy syndrome (FIRES), a catastrophic epileptic encephalopathy with a yet undefined etiology. METHODS:We conducted a retrospective multicenter study on children who had been in...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2011.03250.x
更新日期:2011-11-01 00:00:00