Evidence for a role of the parafascicular nucleus of the thalamus in the control of epileptic seizures by the superior colliculus.

abstract：OBJECTIVE:Drebrins are crucial for synaptic function and dendritic spine development, remodeling, and maintenance. In temporal lobe epilepsy (TLE) patients, a significant hippocampal synaptic reorganization occurs, and synaptic reorganization has been associated with hippocampal hyperexcitability. This study aimed to e...

journal_title：Epilepsia

authors： Dombroski TCD,Peixoto-Santos JE,Maciel K,Baqui MMA,Velasco TR,Sakamoto AC,Assirati JA,Carlotti CG,Machado HR,Sousa GK,Hanamura K,Leite JP,Costa da Costa J,Palmini AL,Paglioli E,Neder L,Spreafico R,Shirao T,Garbelli R

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of medically intractable epilepsy. FCDs are characterized by local architectural disturbances of the neocortex and often by a blurred gray-white matter boundary indicating abnormal white matter myelination. We...

journal_title：Epilepsia

authors： Donkels C,Peters M,Fariña Núñez MT,Nakagawa JM,Kirsch M,Vlachos A,Scheiwe C,Schulze-Bonhage A,Prinz M,Beck J,Haas CA

更新日期：2020-01-01 00:00:00

abstract：:Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes in the fine structure of brain in children with infantile spasms. An understanding of the action of adrenocorticotropic hormone on the biochemistry and development of the brain provides, ...

journal_title：Epilepsia

authors： Riikonen R

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:Genetic variants in STXBP1, which encodes the conserved exocytosis protein Munc18-1, are associated with a variety of infantile epilepsy syndromes. We aimed to develop an in vivo Caenorhabditis elegans model that could be used to test the pathogenicity of such variants in a cost-effective manner. METHODS:The...

journal_title：Epilepsia

authors： Zhu B,Mak JCH,Morris AP,Marson AG,Barclay JW,Sills GJ,Morgan A

更新日期：2020-04-01 00:00:00

abstract：:Two groups of adult outpatients (n = 19 and n = 21) with poorly controlled epilepsy and significant psychological disorder, assessed in terms of rating scales, received two psychological treatments in a balanced cross-over design after stable baseline seizure frequency had been established. A third group (n = 19), who...

journal_title：Epilepsia

authors： Gillham RA

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To evaluate effects of vigabatrin (VGB) by using [123I]iomazenil single-photon emission computed tomography (SPECT) to estimate central gamma-aminobutyric acid (GABA(A))/benzodiazepine receptors (BZRs), and magnetic resonance spectroscopy (MRS) to assess tissue GABA levels. METHODS:Six patients with partial se...

journal_title：Epilepsia

authors： Verhoeff NP,Petroff OA,Hyder F,Zoghbi SS,Fujita M,Rajeevan N,Rothman DL,Seibyl JP,Mattson RH,Innis RB

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:We studied temporal changes of brain sodium and apparent diffusion coefficient (ADC) in a temporal lobe epilepsy (TLE) rat model using kainic acid (KA). METHODS:In situ three-dimensional 23Na magnetic resonance imaging (MRI) and proton diffusion-weighted imaging (DWI) were used. KA at a dose of 10 mg/kg body w...

journal_title：Epilepsia

authors： Wang Y,Majors A,Najm I,Xue M,Comair Y,Modic M,Ng TC

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The incidence of status epilepticus (SE) in Asian children, including Japanese, has not been reported. METHODS:In 2003, we performed an epidemiological study of SE on Japanese children (31 days or older to <15 years of age) in Okayama City by ascertaining all lifetime first episodes of SE. RESULTS:Thirty-s...

journal_title：Epilepsia

authors： Nishiyama I,Ohtsuka Y,Tsuda T,Inoue H,Kunitomi T,Shiraga H,Kimura T,Fujimoto K

更新日期：2007-06-01 00:00:00

abstract：:Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predomina...

journal_title：Epilepsia

authors： Cho KH,Cho YJ,Lee BI,Heo K

更新日期：2016-08-01 00:00:00

abstract：:The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...

journal_title：Epilepsia

authors： Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (...

journal_title：Epilepsia

authors： Foldvary-Schaefer N,De Leon Sanchez I,Karafa M,Mascha E,Dinner D,Morris HH

更新日期：2002-12-01 00:00:00

abstract：UNLABELLED:Low-pressure hydrocephalic state (LPHS) has only recently been described as a distinct clinical entity occurring in patients with bioatrophic lesions of the brain. We report a patient in whom this syndrome developed after subtotal hemispherectomy for intractable epilepsy. METHODS:A 30-year-old man developed...

journal_title：Epilepsia

authors： Daniel RT,Lee GY,Halcrow SJ

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Brivaracetam (BRV) is a new anticonvulsant under development. Although BRV is an analog of levetiracetam (LEV), in addition to being an SV2A ligand, it also inhibits sodium channels in a voltage-dependent manner. The cognitive effects of BRV are uncertain. METHODS:A randomized, double-blind, placebo-controlled...

journal_title：Epilepsia

authors： Meador KJ,Gevins A,Leese PT,Otoul C,Loring DW

更新日期：2011-02-01 00:00:00

abstract：:In this article, we review the incidence and significance of seizures in well-established autoimmune disorders, including multiple sclerosis (MS), diabetes mellitus, celiac disease, thyroid disease, and systemic lupus erythematosus (SLE). The five following presentations discuss the incidence and possible pathogenesis...

journal_title：Epilepsia

authors： Vincent A,Crino PB

更新日期：2011-05-01 00:00:00

abstract：:Mutations in a number of genes encoding voltage-gated sodium channels cause a variety of epilepsy syndromes in humans, including genetic (generalized) epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS, severe myoclonic epilepsy of infancy). Most of these mutations are in the SCN1A gene, and all are d...

journal_title：Epilepsia

authors： Escayg A,Goldin AL

更新日期：2010-09-01 00:00:00

abstract：:An understanding of the basic principles of human inheritance patterns is necessary to appreciate the variety and complexity of genetic influences in the epilepsies. The various modes of human inheritance include single gene (mendelian), chromosomal, mitochondrial, and multifactorial/polygenic. Recent insights regardi...

journal_title：Epilepsia

authors： Bird TD

更新日期：1994-01-01 00:00:00

abstract：:Multiple studies have highlighted how seizures induce different molecular, cellular, and physiologic consequences in an immature brain as compared to a mature brain. In keeping with these studies, seizures early in life alter dentate granule cell birth in different, and even opposing, fashion to adult seizure models (...

journal_title：Epilepsia

authors： Porter BE

更新日期：2008-06-01 00:00:00

abstract：:Clinically, and in experimental models, perinatal hypoxic encephalopathy is commonly associated with seizures. We previously described a rat model in which hypoxia induces seizures and permanently increases in seizure susceptibility in immature rats [postnatal day (P) 10-12] but not in older rats. In the present study...

journal_title：Epilepsia

authors： Jensen FE,Blume H,Alvarado S,Firkusny I,Geary C

更新日期：1995-10-01 00:00:00

abstract：:We performed the blink reflex (BR) in 20 normal volunteers, 13 epileptic patients receiving antiepileptic drug (AED) monotherapy, and 13 epileptic patients receiving AED polytherapy. Comparison of R1, ipsilateral and contralateral R2 and VIIth nerve latencies in the three groups showed no statistically significant dif...

journal_title：Epilepsia

authors： Lancman ME,Cristiano E,Golimstok A,Granillo RJ

更新日期：1993-11-01 00:00:00

abstract：:In patients with epilepsy, improvement in seizure control with treatment of coexisting obstructive sleep apnea (OSA) has been reported, but there is lack of data on the effect of continuous positive airway pressure (CPAP) compliance on seizure control in these patients. We examined the variability in seizure frequency...

journal_title：Epilepsia

authors： Vendrame M,Auerbach S,Loddenkemper T,Kothare S,Montouris G

更新日期：2011-11-01 00:00:00

abstract：:Felbamate (2-phenyl-1,3-propanediol dicarbamate), phenytoin, phenobarbital, ethosuximide, and valproate were evaluated in mice and rats with a battery of well-standardized anticonvulsant test procedures. The results obtained indicate that felbamate exhibits a wider range of experimental anticonvulsant activity than ei...

journal_title：Epilepsia

authors： Swinyard EA,Sofia RD,Kupferberg HJ

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:We used the paired-pulse inhibition paradigm to determine whether the cell loss in the hilus of the dentate gyrus of female rats after kainic acid (KA)-induced status epilepticus (SE) is associated with functional changes in the dentate gyrus. Additionally, we determined whether the lost function could be prese...

journal_title：Epilepsia

authors： Velísek L,Velísková J

更新日期：2002-01-01 00:00:00

abstract：:Quality of life (QOL) must be determined from the patients' subjective viewpoint. To determine QOL in epilepsy, it is necessary to use disease-specific scales. We introduced the Side Effects and Life Satisfaction (SEALS) scale to Japan and performed a comparative study on adult patients with epilepsy and normal subjec...

journal_title：Epilepsia

authors： Kugoh T

更新日期：1996-01-01 00:00:00

abstract：:A transient functional depression of thalamic activity (TFDTA) was induced in acute experiments in cats by the microinjection of 25% KCl into the thalamus. Spontaneous and evoked thalamic electrical activity was markedly depressed at the site of KCl microinjection. Spread of this depression to other thalamic areas oft...

journal_title：Epilepsia

authors： Avoli M,Gloor P

更新日期：1981-08-01 00:00:00

abstract：PURPOSE:In vitro brain preparations have been used extensively to study the generation and propagation of epileptiform activity. Transverse and longitudinal slices of the rodent hippocampus have revealed various patterns of propagation. Yet intact connections between the transverse and longitudinal pathways should gene...

journal_title：Epilepsia

authors： Kibler AB,Durand DM

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complicat...

journal_title：Epilepsia

authors： Bruno E,Böttcher S,Biondi A,Epitashvili N,Manyakov NV,Lees S,Schulze-Bonhage A,Richardson MP,RADAR-CNS Consortium.

更新日期：2020-07-01 00:00:00

abstract：:Determining a prognosis for functional recovery after prolonged status epilepticus can be difficult. Prior case studies have shown that despite seizure control, functional outcomes are typically poor unless a reversible cause is identified. Herein we present a case of idiopathic status epilepticus with a surprisingly ...

journal_title：Epilepsia

authors： Standley K,Abdulmassih R,Benbadis S

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To evaluate the demographic impact of epilepsy a rural area of Africa. METHODS:A cohort study was conducted between 1991 and 2001 in the Mbam Valley (Cameroon) on two groups of subjects (one of persons with epilepsy, and the other of control individuals matched for sex, age, and village of residence). At the e...

journal_title：Epilepsia

authors： Kamgno J,Pion SD,Boussinesq M

更新日期：2003-07-01 00:00:00