Abstract:
:Fetal heart rate (FHR) characteristics of fetuses exposed and not exposed to antiepileptic drugs (AEDs) were studied. FHR is considered to reflect central nervous system (CNS) integrity. Three intervals during pregnancy were investigated: 20, 32, and 38 weeks. At 32 and 38 weeks, FHR was studied in relation to quiet (C1F) and active (C2F) sleep periods. For each tracing, a baseline was determined and accelerations and decelerations were identified. To assess FHR variability, the long-term irregularity, interval difference and absolute beat-to-beat indexes, and the bandwidth were calculated for 30-s intervals between accelerations and decelerations. No marked differences were noted between study and control groups concerning basal FHR and the occurrence of accelerations. For FHR derived from the fetal ECG, all indexes of FHR variability and the bandwidth were lower for the study group as compared with the control group, although the differences did not reach statistical significance. Our study shows that chronic prenatal exposure to AEDs does not seriously interfere with modulation of fetal heart rhythm by the CNS.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Swartjes JM,van Geijn HP,Meinardi H,Mantel Rdoi
10.1111/j.1528-1157.1992.tb02353.xsubject
Has Abstractpub_date
1992-07-01 00:00:00pages
721-8issue
4eissn
0013-9580issn
1528-1167journal_volume
33pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract::Convulsive epilepsies are generally unmistakable. Absence epilepsies, which are easily recognized by the provocation of an episode during hyperventilation and by the typical features of the EEG, can be overdiagnosed, especially in the child who daydreams in class and has scattered, asymptomatic, epileptogenic EEG chan...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1157.1994.tb05936.x
更新日期:1994-01-01 00:00:00
abstract::We compared zonisamide monotherapy (12 weeks) to carbamazepine monotherapy (12 weeks) after phenytoin baseline monotherapy (8 weeks) in an open crossover pilot study of eight adults with uncontrolled partial seizures. Zonisamide had definite antiepileptic activity in five subjects. In two of these, response to zonisam...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1985.tb05408.x
更新日期:1985-05-01 00:00:00
abstract::Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing response...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1528-1167.2012.03654.x
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Our aim was to develop a screening test to predict Dravet syndrome before the first birthday based on the clinical characteristics of infants and the SCN1A mutation analysis. METHODS:Ninety-six patients who experienced febrile seizures before the age of one were enrolled. The patients were divided into two gro...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01475.x
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:Lesion-negative refractory partial epilepsy is a major challenge in the assessment of patients for potential surgery. Finding a potential epileptogenic lesion simplifies assessment and is associated with good outcome. Here we describe imaging features of subtle parahippocampal dysplasia in five cases that were ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02103.x
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:The pineal hormone melatonin has been shown to enhance hippocampal excitability. We therefore investigated whether inactivation of hippocampal melatonin receptors affects behavioral seizures. METHODS:Intrahippocampal infusions were performed in rats to study the effect of different melatonin receptor antagonis...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.30204.x
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:Mycoplasma pneumoniae, a common respiratory pathogen, has been implicated as an etiology of encephalitis, but there are few reports about it and postencephalitic epilepsy. This study aimed to investigate clinical factors, electroencephalography, and neuroradiologic features of M. pneumoniae-related encephalitis...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03218.x
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:Generalized convulsive status epilepticus (GCSE) needs immediate management. Despite guidelines, adherence to management protocols is often poor, this contributing to poor outcome. We aimed to evaluate the usefulness of a management protocol in GCSE. METHODS:This is a prospective population-based study of cons...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2010.02688.x
更新日期:2010-10-01 00:00:00
abstract::We performed positron emission tomography (PET) with [11C]deuterium-deprenyl in 9 patients with temporal lobe epilepsy (TLE) undergoing evaluation for possible epilepsy surgery. Seven patients had unilateral and 2 had bilateral mesiotemporal epileptic foci based on the preoperative investigation including ictal EEG di...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1995.tb01051.x
更新日期:1995-07-01 00:00:00
abstract::Men are different from women, and patients with epilepsy are different in many aspects from healthy control subjects. Quantitative or semiquantitative analysis of neuroimaging data depends on the comparison between either a single patient against a group of healthy or unaffected controls, or comparisons between groups...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2011.03150.x
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:Previous quantitative trait loci (QTL) mapping studies from our laboratory identified a 6.6 Mb segment of distal chromosome 1 that contains a gene (or genes) having a strong influence on the difference in seizure susceptibility between C57BL/6 (B6) and DBA/2 (D2) mice. A gene transfer strategy involving a bacte...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01126.x
更新日期:2007-09-01 00:00:00
abstract::In animal models, inflammation is both a cause and consequence of seizures. Less is known about the role of inflammation in human epilepsy. We performed positron emission tomography (PET) using a radiotracer sensitive to brain inflammation in a patient with frontal epilepsy ~36 h after a seizure as well as during a se...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13457
更新日期:2016-09-01 00:00:00
abstract::Eleven patients had seizures with unilateral temporal lobe onset recorded with simultaneous bilateral medial temporal depth electrodes and neocortical (subdural) electrodes at least on the side of seizure onset. Of a total of 55 seizures, four had simultaneous onset in neocortex and hippocampus, and 51 had onset in un...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1987.tb03676.x
更新日期:1987-09-01 00:00:00
abstract:PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00563.x
更新日期:2006-07-01 00:00:00
abstract::We assessed the effects of phenytoin (PHT) overdosage on ballistic arm abduction movements in nine epileptic patients receiving long-term PHT treatment. During the overdosage period, all but one showed clinical abnormalities referable to impaired cerebellar function; one also had slowness of movement. Ballistic moveme...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1992.tb02331.x
更新日期:1992-03-01 00:00:00
abstract::We sought to determine if there are differences in the incidence of seizure disorders between the children of the indigenous and immigrant (predominantly Pakistani) populations of Bradford, United Kingdom. Annual incidence rates per 100,000 for new onset seizures were calculated along with Townsend deprivation scores....
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01097.x
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To assess the role of 1H-magnetic resonance spectroscopy (MRS) in detecting biochemical abnormalities in neuronal migration disorders (NMDs). METHODS:We performed 1H-MRS studies on 17 brain NMD areas [five polymicrogyria, eight subcortical heterotopia, and four cortical dysplasia on magnetic resonance imaging ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb00793.x
更新日期:1999-07-01 00:00:00
abstract::The tendency for four strains of parathyroidectomized (PTx) rats to convulse after pinealectomy (Px) was observed in this experiment; telencephalic serotonin, norepinephrine, and dopamine were examined to note any correlation between amines and convulsions. The strains of rats tested were Sprague-Dawley, Wistar, Long-...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1978.tb05023.x
更新日期:1978-04-01 00:00:00
abstract:PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01864.x
更新日期:2009-05-01 00:00:00
abstract::We studied a 41-year-old woman who had nocturnal somatosensory seizures followed by orgasm. The interictal EEG showed discrete left central parietal region paroxysmal activity that markedly increased during sleep. Eight electroclinical seizures were recorded during sleep polygraphic recording. Orgasms occurred coincid...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1988.tb03774.x
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12697
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life-threatening. Guidelines for the care of these patients are missing. The aim of this multicenter study was to evaluate the management and long-term outcome in patients with IA and IB. ...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2010.02961.x
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The present study aimed to clarify the effect of electrical stimulation and lesioning of the anterior nucleus of the thalamus (ANT) on kainic acid (KA)-induced focal cortical seizures in a rat model. To address the mechanism underlying these anticonvulsant actions, cerebral glucose metabolism after ANT electric...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00948.x
更新日期:2007-02-01 00:00:00
abstract::We analyzed the results of neuroimaging studies in patients with periodic lateralized epileptiform discharges (PLEDs) or bilateral independent periodic lateralized epileptiform discharges (BIPLEDs) for localization of lesions in gray or white matter to determine if "cortical isolation" is a critical mechanism in the p...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1995.tb01666.x
更新日期:1995-01-01 00:00:00
abstract::The purpose of the study was to examine the impact of idiopathic epilepsy on mothers and fathers in terms of strain, burden of care, worries and perception of vulnerability. Data were collected and analyzed shortly after the diagnosis (T0) and 12 months later (T1). The results indicated that at T0 parents of children ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01145.x
更新日期:2007-09-01 00:00:00
abstract::This study aimed to determine clinical features of adult patients with gelastic seizures recorded on video -electroencephalography (EEG) over a 5-year period. We screened video-EEG telemetry reports for the occurrence of the term "gelastic" seizures, and assessed the semiology, EEG features, and duration of those seiz...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12868
更新日期:2015-01-01 00:00:00
abstract::Cardiac changes may occasionally occur during vagus nerve stimulation (VNS) used in epileptic patients. As they can be potentially life-threatening, it is important to detect them, and this is why an intraoperative test is performed during the implantation. Few cases of asystole during this test have been described. O...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01918.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:The objective was to systematically review studies that have focused on behavioral and emotional functioning before (baseline) and after (follow-up) pediatric epilepsy surgery. METHODS:The systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyse...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.14737
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 +/- 1 days; the id...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.46904.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13010
更新日期:2015-06-01 00:00:00