Abstract:
PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected during a 3-4 month baseline, and for 26-32 months after DBS surgery, with AEDs held constant. RESULTS:Case 1, age 45, with bitemporal seizures, had about half the seizure frequency but still fell with injuries. Case 2, age 46, with left frontal encephalomalacia, had a frequency reduction of about one-third, but a more meaningful reduction of seizure severity and injuries. CONCLUSIONS:Subthalamic DBS partly reduced partial-onset seizures, but the quality of life was more affected by seizure-related injuries.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Handforth A,DeSalles AA,Krahl SEdoi
10.1111/j.1528-1167.2006.00563.xsubject
Has Abstractpub_date
2006-07-01 00:00:00pages
1239-41issue
7eissn
0013-9580issn
1528-1167pii
EPI563journal_volume
47pub_type
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