Progabide treatment in severe epilepsy: a double-blind cross-over trial versus placebo.

Abstract:

:Twenty therapy-resistant epileptic patients entered a double-blind, randomized, two-period, cross-over trial comparing progabide (19.3-36 mg/kg/day) and placebo as add-on drugs to standard therapy. Each period lasted 6 weeks with a gradual crossover during 4 days. Five patients were dropped because of reasons unrelated to treatment. Among the 15 patients who completed the study, seven had partial, six primary generalized, and two secondary generalized epilepsies. Preexisting antiepileptic drugs (AEDs) ranging from one to three per patient (mean 2.2 AEDs/patient) were maintained unchanged during the trial. Efficacy was assessed biweekly by means of total seizure counts, counts of each seizure type, and global clinical judgment. At the same time intervals, safety was assessed by means of reports of adverse events, clinical and neurological examination, laboratory tests, and measurement of plasma concentrations of progabide and associated AEDs. According to the clinical global judgment, eight patients were considered improved during progabide treatment. Seizures were reduced in 14 of 15 patients during the progabide as compared with the placebo period. During the progabide period, the reduction of the total seizure count was 45 and 58% in two patients and 88-97% in six patients. A significant reduction of the total seizure number was observed in the progabide period as compared with the placebo period, both in the whole patient group (p less than 0.01) and in the two subgroups of patients with generalized (p less than 0.01) and partial (p less than 0.05) epilepsies.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Epilepsia

journal_title

Epilepsia

authors

Martínez-Lage JM,Bossi L,Morales G,Martínez Vila E,Orofiamma B,Viteri C

doi

10.1111/j.1528-1157.1984.tb03466.x

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

586-93

issue

5

eissn

0013-9580

issn

1528-1167

journal_volume

25

pub_type

临床试验,杂志文章,随机对照试验
  • Hippocampal T2 signal change during amygdala kindling epileptogenesis.

    abstract:PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00368.x

    authors: Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

    更新日期:2006-01-01 00:00:00

  • Blood-brain barrier dysfunction in brain diseases: clinical experience.

    abstract::The blood-brain barrier, a unique feature of the cerebral vasculature, is gaining attention as a feature in common neurologic disorders including stroke, traumatic brain injury, epilepsy, and schizophrenia. Although acute blood-brain barrier dysfunction can induce cerebral edema, seizures, or neuropsychiatric symptoms...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2012.03697.x

    authors: Schoknecht K,Shalev H

    更新日期:2012-11-01 00:00:00

  • Nitric oxide synthase expression in the cerebral cortex of patients with epilepsy.

    abstract:PURPOSE:Nitric oxide (NO), a short-lived radical synthesized from L-arginine by activation of the enzyme nitric oxide synthase (NOS), has been implicated in the pathophysiology of epilepsy by some investigators. However, the current data about NO and NOS in epilepsy are controversial and are derived only from animal mo...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.2000.tb04603.x

    authors: González-Hernández T,García-Marín V,Pérez-Delgado MM,González-González ML,Rancel-Torres N,González-Feria L

    更新日期:2000-10-01 00:00:00

  • Infantile spasms: some new theoretical aspects.

    abstract::Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes in the fine structure of brain in children with infantile spasms. An understanding of the action of adrenocorticotropic hormone on the biochemistry and development of the brain provides, ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1983.tb04875.x

    authors: Riikonen R

    更新日期:1983-04-01 00:00:00

  • Comprehensive care of the epilepsy patient--control, comorbidity, and cost.

    abstract::Traditionally, control of seizures in patients with epilepsy is viewed as the most important clinical outcome. Yet, current antiepileptic drugs (AEDs) do not always achieve this. Around 30-40% of patients remain uncontrolled despite pharmacological intervention. Poor tolerability of AEDs is a large part of the problem...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.0013-9580.2004.455002.x

    authors: Bazil CW

    更新日期:2004-01-01 00:00:00

  • Increased excitability and molecular changes in adult rats after a febrile seizure.

    abstract::Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12061

    authors: Reid AY,Riazi K,Campbell Teskey G,Pittman QJ

    更新日期:2013-04-01 00:00:00

  • Visual inattention in West syndrome: a neuropsychological and neurofunctional imaging study.

    abstract::Visual behavior is frequently impaired at onset of West syndrome (WS). We studied the neuropsychological outcome of eight children who had cryptogenic WS and moderate to severe visual impairment at the onset of epilepsy. At the last examination, a regional cerebral blood flow study using SPECT (single photon emission ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1993.tb00448.x

    authors: Jambaqué I,Chiron C,Dulac O,Raynaud C,Syrota P

    更新日期:1993-07-01 00:00:00

  • A case of startle epilepsy and SSMA seizures documented with subdural recordings.

    abstract:PURPOSE:To study the mechanisms of startle-induced supplementary sensorimotor area (SSMA) seizures. METHODS:We present a patient investigated with indwelling subdural grid electrodes covering both the SSMA and the dorsolateral frontal lobe. RESULTS:We found a simultaneous seizure onset in the right dorsolateral premo...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1999.tb00813.x

    authors: Serles W,Leutmezer F,Pataraia E,Olbrich A,Gröppel G,Czech T,Baumgartner C

    更新日期:1999-07-01 00:00:00

  • First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat.

    abstract:OBJECTIVE:A large number of studies have highlighted the important role of the gut microbiota in the pathophysiology of neurological disorders, suggesting that its manipulation might serve as a treatment strategy. We hypothesized that the gut microbiota participates in absence seizure development and maintenance in the...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16813

    authors: Citraro R,Lembo F,De Caro C,Tallarico M,Coretti L,Iannone LF,Leo A,Palumbo D,Cuomo M,Buommino E,Nesci V,Marascio N,Iannone M,Quirino A,Russo R,Calignano A,Constanti A,Russo E,De Sarro G

    更新日期:2021-01-11 00:00:00

  • Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy.

    abstract:PURPOSE:Hypothalamic regulation of the reproductive axis in temporal lobe epilepsy (TLE), represented by the ultradian pulsatile secretion of luteinizing hormone (LH), has been shown to be altered interictally and postictally. Our objective is to determine if epilepsy or seizures disrupt normal circadian fluctuations o...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00617.x

    authors: Quigg M,Kiely JM,Johnson ML,Straume M,Bertram EH,Evans WS

    更新日期:2006-09-01 00:00:00

  • Effects of carbamazepine on the hypothalamic-pituitary-gonadal axis in male patients with epilepsy: a prospective study.

    abstract::The effects of carbamazepine (CBZ) monotherapy on serum sex hormone levels and on pituitary responsiveness to various stimuli were evaluated in a prospective study with 21 male patients with epilepsy. The serum levels of testosterone (T), free testosterone (FT), sex hormone binding globulin (SHBG), estradiol (E2), lut...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1989.tb05324.x

    authors: Isojärvi JI,Pakarinen AJ,Myllylä VV

    更新日期:1989-07-01 00:00:00

  • Muscarinic receptor loss and preservation of presynaptic cholinergic terminals in hippocampal sclerosis.

    abstract:PURPOSE:Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. Howev...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1999.tb01986.x

    authors: Pennell PB,Burdette DE,Ross DA,Henry TR,Albin RL,Sackellares JC,Frey KA

    更新日期:1999-01-01 00:00:00

  • Epidemiology of epilepsy in rural Benin: prevalence, incidence, mortality, and follow-up.

    abstract:PURPOSE:Epilepsy is a major clinical and social issue in Africa. This study was conducted to estimate the prevalence, incidence, mortality, and therapeutic outcome in rural Djidja in Benin. METHODS:This was a two-phase study with a cross-sectional phase and 18 months of follow-up. In the first phase, information was o...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12082

    authors: Houinato D,Yemadje LP,Glitho G,Adjien C,Avode G,Druet-Cabanac M,Preux PM

    更新日期:2013-04-01 00:00:00

  • Epilepsy in the elderly.

    abstract::The elderly are the most rapidly growing segment of the population and the incidence of epilepsy is higher in the elderly than in any other age group. They have been subdivided into the "young old," 65-74 years, "middle old" 75-84 years, and the "old old," 85 years or older. But further subdivisions are needed: person...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00664.x

    authors: Leppik IE

    更新日期:2006-01-01 00:00:00

  • Role of the superior colliculus in the expression of acute and kindled audiogenic seizures in Wistar audiogenic rats.

    abstract:PURPOSE:The role of the superior colliculus (SC) in seizure expression is controversial and appears to be dependent upon the epilepsy model. This study shows the effect of disconnection between SC deep layers and adjacent tissues in the expression of acute and kindling seizures. METHODS:Subcollicular transections, abl...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2009.02164.x

    authors: Doretto MC,Cortes-de-Oliveira JA,Rossetti F,Garcia-Cairasco N

    更新日期:2009-12-01 00:00:00

  • Deep brain stimulation of the subthalamic nucleus as adjunct treatment for refractory epilepsy.

    abstract:PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00563.x

    authors: Handforth A,DeSalles AA,Krahl SE

    更新日期:2006-07-01 00:00:00

  • Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis.

    abstract:OBJECTIVE:Drebrins are crucial for synaptic function and dendritic spine development, remodeling, and maintenance. In temporal lobe epilepsy (TLE) patients, a significant hippocampal synaptic reorganization occurs, and synaptic reorganization has been associated with hippocampal hyperexcitability. This study aimed to e...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16595

    authors: Dombroski TCD,Peixoto-Santos JE,Maciel K,Baqui MMA,Velasco TR,Sakamoto AC,Assirati JA,Carlotti CG,Machado HR,Sousa GK,Hanamura K,Leite JP,Costa da Costa J,Palmini AL,Paglioli E,Neder L,Spreafico R,Shirao T,Garbelli R

    更新日期:2020-08-01 00:00:00

  • Some facts about sleep relevant for Landau-Kleffner syndrome.

    abstract::Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2009.02218.x

    authors: Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

    更新日期:2009-08-01 00:00:00

  • The effects of transient functional depression of the thalamus on spindles and on bilateral synchronous epileptic discharges of feline generalized penicillin epilepsy.

    abstract::A transient functional depression of thalamic activity (TFDTA) was induced in acute experiments in cats by the microinjection of 25% KCl into the thalamus. Spontaneous and evoked thalamic electrical activity was markedly depressed at the site of KCl microinjection. Spread of this depression to other thalamic areas oft...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1981.tb06155.x

    authors: Avoli M,Gloor P

    更新日期:1981-08-01 00:00:00

  • Status epilepticus characterized by repetitive asymmetrical atonia: two cases accompanied by partial seizures.

    abstract::Two cases of discontinuous status epilepticus (SE) characterized by repetitive asymmetrical atonic episodes associated with diffuse but asymmetrical spike waves are reported. Both patients also had partial seizures and interictal rolandic discharges. Dynamic EEG topography was performed to investigate the location or ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1990.tb06103.x

    authors: Kanazawa O,Kawai I

    更新日期:1990-09-01 00:00:00

  • Anticonvulsant hypersensitivity syndrome: is there a role for immunomodulation?

    abstract::The anticonvulsant hypersensitivity syndrome (AHS) is an idiosyncratic immunologic reaction to certain anticonvulsant medications, in which internal organ involvement may lead to fatal multisystemic failure. This syndrome has been associated with the use of aromatic ring-containing agents such as phenytoin, carbamazep...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01720.x

    authors: Cumbo-Nacheli G,Weinberger J,Alkhalil M,Thati N,Baptist AP

    更新日期:2008-12-01 00:00:00

  • Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices.

    abstract::Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1994.tb05973.x

    authors: Zhang CL,Gloveli T,Heinemann U

    更新日期:1994-01-01 00:00:00

  • A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy.

    abstract:PURPOSE:To conduct the first randomized trial on classical and medium-chain triglyceride (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. METHODS:One hundred forty-five children with intractable epilepsy were randomized to receive a classical or an MCT diet. Seizure ...

    journal_title:Epilepsia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1528-1167.2008.01870.x

    authors: Neal EG,Chaffe H,Schwartz RH,Lawson MS,Edwards N,Fitzsimmons G,Whitney A,Cross JH

    更新日期:2009-05-01 00:00:00

  • Knowledge, attitudes, and perceptions of epilepsy in Asia: toward a uniform study protocol.

    abstract:PURPOSE:Knowledge, attitudes, and perceptions of epilepsy (KAPE) among the public play a major role in determining the extent to which people with epilepsy can be integrated into their society. KAPE SURVEYS IN ASIA:Surveys conducted among Chinese in China, Taiwan, Malaysia, Singapore, and Hong Kong demonstrated simila...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.0013-9580.2005.461014.x

    authors: Lim SH,Pan A

    更新日期:2005-01-01 00:00:00

  • Development of intelligence and neuropsychological impairment scales for the Washington Psychosocial Seizure Inventory.

    abstract::The Washington Psychosocial Seizure Inventory (WPSI) was used to evaluate the relative extent of psychosocial problems in 379 adults with epilepsy, having differing levels of intelligence and neuropsychological impairment. In general, there were more psychosocial problems when abilities were decreased. Two new scales ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1983.tb04859.x

    authors: Dodrill CB

    更新日期:1983-02-01 00:00:00

  • Infantile spasms in Down syndrome: good response to a short course of vigabatrin.

    abstract:PURPOSE:To evaluate the efficacy of vigabatrin (VGB) in the treatment of infantile spasms (ISs) associated with Down syndrome (DS) and to assess the feasibility of early discontinuation to reduce the possible retinal toxicity. METHODS:Five children with ISs with DS were treated with vigabatrin as first-line monotherap...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1528-1157.2001.13501.x

    authors: Nabbout R,Melki I,Gerbaka B,Dulac O,Akatcherian C

    更新日期:2001-12-01 00:00:00

  • Agenesis of internal carotid artery associated with symptomatic partial epilepsy.

    abstract::An 8-year-old Chinese girl had a first episode of symptomatic partial epilepsy at age 2 years. Despite regular treatment with antiepileptic drugs (AEDs), the seizures remitted and exacerbated. Epileptiform EEG discharges were evident, arising from the left centroparietal region. Magnetic resonance imaging (MRI) and co...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1994.tb01808.x

    authors: Wang PJ,Liu HM,Young C,Lin MY,Shen YZ

    更新日期:1994-11-01 00:00:00

  • Seizure characterization and electroencephalographic features in Glut-1 deficiency syndrome.

    abstract:PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2003.05302.x

    authors: Leary LD,Wang D,Nordli DR Jr,Engelstad K,De Vivo DC

    更新日期:2003-05-01 00:00:00

  • In vivo inhibition of incorporation of [U-14C]glucose into proteins in experimental focal epilepsy.

    abstract::The in vivo incorporation of [14C] from [U-14C]-glucose into rat brain proteins from different cortical areas was examined in three different experimental focal epilepsies: cobalt, freeze-lesions, and tityustoxin. When [U-14C]-glucose was injected intraperitoneally into awake and unrestrained animals with marked signs...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1982.tb05424.x

    authors: Coutinho-Netto J,Boyar MM,Abdul-Ghani AS,Bradford HF

    更新日期:1982-08-01 00:00:00

  • A screening test for the prediction of Dravet syndrome before one year of age.

    abstract:PURPOSE:Our aim was to develop a screening test to predict Dravet syndrome before the first birthday based on the clinical characteristics of infants and the SCN1A mutation analysis. METHODS:Ninety-six patients who experienced febrile seizures before the age of one were enrolled. The patients were divided into two gro...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2007.01475.x

    authors: Hattori J,Ouchida M,Ono J,Miyake S,Maniwa S,Mimaki N,Ohtsuka Y,Ohmori I

    更新日期:2008-04-01 00:00:00