Abstract:
:Aminophylline (50 and 100 mg/kg) and CGS 8216 (20 and 40 mg/kg) decreased the anticonvulsant potency of diazepam (5 and 10 mg/kg) against electroshock-induced seizures. It should be emphasized that aminophylline moderately affected the protective action of the benzodiazepine at a dose of 5 mg/kg, whereas it was equipotent with CGS 8216 with regard to diazepam at a dose of 10 mg/kg. Consequently, participation of a purinergic component in the anticonvulsant action of diazepam is suggested. On the other hand, the use of aminophylline in epileptic patients suffering from asthma seems unjustified.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Czuczwar SJ,Turski WA,Ikonomidou C,Turski Ldoi
10.1111/j.1528-1157.1985.tb05713.xsubject
Has Abstractpub_date
1985-11-01 00:00:00pages
693-6issue
6eissn
0013-9580issn
1528-1167journal_volume
26pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract::Benzodiazepines (BDZ) interact with components of neuronal membranes to modify excitability in three different ways. Action at a high affinity central receptor (dissociation constant, KD, of 3 nM) linked to the GABAA recognition site enhances the inhibitory action of GABA by increasing the number of openings of Cl- ch...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1986.tb05731.x
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To assess the role of 1H-magnetic resonance spectroscopy (MRS) in detecting biochemical abnormalities in neuronal migration disorders (NMDs). METHODS:We performed 1H-MRS studies on 17 brain NMD areas [five polymicrogyria, eight subcortical heterotopia, and four cortical dysplasia on magnetic resonance imaging ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb00793.x
更新日期:1999-07-01 00:00:00
abstract::We compared zonisamide monotherapy (12 weeks) to carbamazepine monotherapy (12 weeks) after phenytoin baseline monotherapy (8 weeks) in an open crossover pilot study of eight adults with uncontrolled partial seizures. Zonisamide had definite antiepileptic activity in five subjects. In two of these, response to zonisam...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1985.tb05408.x
更新日期:1985-05-01 00:00:00
abstract:OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12869
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12697
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate whether the nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC). The Pf is one of the main ascending projections of the SC, the disinhibition of which has been shown to suppress seizures in d...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.30304.x
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Febrile seizures (FS) are the most common type of convulsive events in children. FS are suggested to result from a combination of genetic and environmental factors. However, the pathophysiologic mechanisms underlying FS remain unclear. Using an animal model of experimental FS, it was demonstrated that hyperther...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03259.x
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Inducing sleep deprivation is supposed to increase interictal epileptic discharges on EEGs from children suspected of having epilepsy. Although it is supposed that depriving a child from sleep is a burden for both child and parent, this assumption has not been investigated in any study so far. M...
journal_title:Epilepsia
pub_type: 信件
doi:10.1111/j.1528-1167.2005.14405.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To assess incidence, prevalence, risk factors, and prognosis of peripartum depression and anxiety in a prospective study of women with epilepsy. METHOD:Pregnancies in women with epilepsy (n=706) were compared to pregnancies in all women without epilepsy (n=106,511) including women with specified nonepileptic...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12884
更新日期:2015-01-01 00:00:00
abstract::An 8-year-old Chinese girl had a first episode of symptomatic partial epilepsy at age 2 years. Despite regular treatment with antiepileptic drugs (AEDs), the seizures remitted and exacerbated. Epileptiform EEG discharges were evident, arising from the left centroparietal region. Magnetic resonance imaging (MRI) and co...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1994.tb01808.x
更新日期:1994-11-01 00:00:00
abstract::This article reviews the potential interactions of antiepileptic drugs (AEDs) and the pharmacokinetic and pharmacodynamic principles involved. It describes the absorptive and distributive properties of AEDs and the effects on protein binding, hepatic metabolism, and elimination resulting from co-administration of AEDs...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1157.2000.tb02944.x
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:With intraperitoneal N-methyl-D-aspartate (NMDA; 15-200 mg/kg) administration, we attempted to develop an animal model of age-specific West syndrome to serve for testing of putative anticonvulsant drugs and to determine the mechanisms of this disorder. METHODS:Experiments were performed in 12-, 18-, and 60-day...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb02006.x
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:Autoantibodies against glutamic acid decarboxylase (GAD) and the voltage-gated potassium channel (VGKC) complex are associated with distinct subtypes of limbic encephalitis regarding clinical presentation, response to therapy, and outcome. The aim of this study was to investigate white matter changes in these...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13297
更新日期:2016-03-01 00:00:00
abstract::The interictal EEG provides information that aids in diagnosis and management of epilepsy. One must remember that the EEG is merely a tool, and its usefulness depends largely upon the skill of the individual who wields it. Like all diagnostic tests, it has significant limitations and cannot substitute for a careful hi...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2006.00654.x
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:This study investigated the functional plasticity of the brain to reconstitute and compensate for verbal memory functions after epilepsy surgery of left temporocortical and temporomesial structures. We hypothesized that memory outcome would be best when surgery is performed within the period of cerebral plastic...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1998.tb01392.x
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:In patients with mesial temporal lobe epilepsy (MTLE) it remains an unresolved issue whether the interictal decrease in N-acetyl aspartate (NAA) detected by proton magnetic resonance spectroscopy ((1)H-MRS) reflects the epilepsy-associated loss of hippocampal pyramidal neurons or metabolic dysfunction. METHODS...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01280.x
更新日期:2008-01-01 00:00:00
abstract::Monotherapy is the policy for management of patients with epilepsy. With increasing knowledge of the biology of epilepsy and of the modes of action of antiepileptic drugs (AEDs), this concept must be reevaluated. When monotherapy fails to control seizures, subsequent treatment should be based on "rational pharmacology...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1528-1157.1994.tb02447.x
更新日期:1994-03-01 00:00:00
abstract::Eleven patients had seizures with unilateral temporal lobe onset recorded with simultaneous bilateral medial temporal depth electrodes and neocortical (subdural) electrodes at least on the side of seizure onset. Of a total of 55 seizures, four had simultaneous onset in neocortex and hippocampus, and 51 had onset in un...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1987.tb03676.x
更新日期:1987-09-01 00:00:00
abstract:PURPOSE:To determine if seizure frequency differs between anovulatory and ovulatory cycles. METHODS:The data came from the 3-month baseline phase of an investigation of progesterone therapy for intractable focal onset seizures. Of 462 women who enrolled, 281 completed the 3-month baseline phase and 92 had both anovula...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2011.03194.x
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. A substantial number of past studies examined factors that predict memory decline after surger...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00807.x
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital, valproate, and ethosuximide, or vehicle. METHODS:In acute studies of anticonvulsant efficacy, the AEDs were administered via or...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01552.x
更新日期:2008-07-01 00:00:00
abstract::Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presen...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1975.tb06053.x
更新日期:1975-06-01 00:00:00
abstract::Amygdala kindling, the progressive development of seizures following repeated electrical stimulation, has been used as a model of epileptogenesis, neural memory, and the development of behavioral alterations. In an attempt to interfere with the kindling process, electroconvulsive seizures (ECS) were administered 6 h p...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1984.tb04181.x
更新日期:1984-04-01 00:00:00
abstract::The intracarotid amobarbital procedure (IAP) is frequently used to determine hemispheric language dominance and memory competence in individuals with intractable epilepsy before surgical intervention. The present study focused on outcome results concerning use of this technique in children. The IAP was an effective to...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1992.tb01755.x
更新日期:1992-11-01 00:00:00
abstract::A population study was performed to estimate the prevalence of epilepsy in the juvenile population of Valladolid, Spain. Using a mixed questionnaire (postal-domiciliary), we studied a sample of 5,100 primary school pupils (aged between 6 and 14 years) and 48 pupils receiving state-run special education. We also identi...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1991.tb05535.x
更新日期:1991-11-01 00:00:00
abstract::In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...
journal_title:Epilepsia
pub_type: 历史文章,杂志文章
doi:10.1111/j.1528-1167.2009.02037.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:Seizures are common in individuals with duplications of chromosome 15q11.2-q13 (Dup15q). The goal of this study was to examine the phenotypes and treatments of seizures in Dup15q in a large population. METHODS:A detailed electronic survey was conducted through the Dup15q Alliance containing comprehensive que...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12530
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to develop a quantitative framework to estimate the likelihood of multifocal epilepsy based on the number of unifocal seizures observed in the epilepsy monitoring unit (EMU). METHODS:Patient records from the EMU at Massachusetts General Hospital (MGH) from 2012 to 2014 were asse...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13090
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:Diffusion-weighted magnetic resonance imaging (DWI) after focal status epilepticus has demonstrated focal alterations of the apparent diffusion coefficient (ADC) in the epileptogenic zone. We hypothesized that localized dynamic alterations of brain diffusion during the immediate postictal state will be detectab...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2003.07802.x
更新日期:2003-01-01 00:00:00
abstract::The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...
journal_title:Epilepsia
pub_type: 古典文章,杂志文章
doi:10.1111/j.1528-1167.2009.02078.x
更新日期:2009-07-01 00:00:00