Human hippocampal seizure spread studied by depth and subdural recording: the hippocampal commissure.

abstract：:Advanced variant detection in genes underlying risk of sudden unexpected death in epilepsy (SUDEP) can uncover extensive epistatic complexity and improve diagnostic accuracy of epilepsy-related mortality. However, the sensitivity and clinical utility of diagnostic panels based solely on established cardiac arrhythmia ...

journal_title：Epilepsia

authors： Klassen TL,Bomben VC,Patel A,Drabek J,Chen TT,Gu W,Zhang F,Chapman K,Lupski JR,Noebels JL,Goldman AM

更新日期：2014-02-01 00:00:00

abstract：:Forty-eight patients with complex partial and/or tonic-clonic seizures were treated with an 8 p.m. single dose of carbamazepine slow release (CBZ-SR) monotherapy. The steady-state serum level profiles of carbamazepine (CBZ) and its metabolites CBZ-10,11-epoxide (CBZE) and 10,11-dihydro-CBZ-10,11-diole (CBZD) during 24...

journal_title：Epilepsia

authors： Stefan H,Schäfer H,Kuhnen C,Schneider S

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:The processes underlying sudden unexpected death in epilepsy (SUDEP) remain elusive, but centrally mediated cardiovascular or respiratory collapse is suspected. Volume changes in brain areas mediating recovery from extreme cardiorespiratory challenges may indicate failure mechanisms and allow prospective iden...

journal_title：Epilepsia

authors： Allen LA,Vos SB,Kumar R,Ogren JA,Harper RK,Winston GP,Balestrini S,Wandschneider B,Scott CA,Ourselin S,Duncan JS,Lhatoo SD,Harper RM,Diehl B

更新日期：2019-04-01 00:00:00

abstract：:We report the case of a 3-year-old boy with status gelasticus symptomatic to a giant hypothalamic hamartoma despite two previous hypothalamic hamartoma surgeries using pterional approaches from each side. Following his third resection employing an endoscopic, transventricular approach, he has been seizure free for 6 m...

journal_title：Epilepsia

authors： Ng YT,Rekate HL

更新日期：2011-01-01 00:00:00

abstract：:This study sought to determine the frequency and clinical significance of nonhabitual seizures in 101 consecutive patients undergoing presurgical intracranial electroencephalography intracranial (icEEG) recording. We compared clinical data, recording details, and postsurgical outcome in patients with nonhabitual seizu...

journal_title：Epilepsia

authors： Kovac S,Rodionov R,Chinnasami S,Wehner T,Scott CA,McEvoy AW,Miserocchi A,Diehl B

更新日期：2014-01-01 00:00:00

abstract：:Currently, there are 4 published scales evaluating status epilepticus (SE) prognosis: the Status Epilepticus Severity Score (STESS), the Epidemiology-based Mortality score in Status Epilepticus (EMSE), the modified STESS (mSTESS), and the Encephalitis Nonconvulsive Status Epilepticus Diazepam Resistence Imaging Trache...

journal_title：Epilepsia

authors： Yuan F,Gao Q,Jiang W

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Several experimental paradigms of seizure induction that produce epilepsy as a consequence have been shown to be associated with the proliferation of dentate granule cells. In developing animals, the acute sequela of hilar damage and the chronic sequelae of spontaneous seizures and mossy fiber synaptic reorgani...

journal_title：Epilepsia

authors： Sankar R,Shin D,Liu H,Katsumori H,Wasterlain CG

更新日期：2000-01-01 00:00:00

abstract：:Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presen...

journal_title：Epilepsia

authors： Mitra J,Snider RS

更新日期：1975-06-01 00:00:00

abstract：PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected...

journal_title：Epilepsia

authors： Handforth A,DeSalles AA,Krahl SE

更新日期：2006-07-01 00:00:00

abstract：:The antiepileptic drug sodium valproate (VPA) can provoke a thrombocytopenia or platelet dysfunction, with or without hemorrhages. These unwanted side effects are probably infrequent or, at least, have little clinical importance except in patients undergoing surgery. Thromboelastography appears to be a reliable screen...

journal_title：Epilepsia

authors： Loiseau P

更新日期：1981-04-01 00:00:00

abstract：:Two healthy male volunteers received 10 mg carbamazepine (CBZ) as a 2-h constant-rate intravenous (i.v.) infusion and 100 mg 15N-labeled CBZ as a 2% oral suspension, concomitantly. The two compounds have identical pharmacokinetics. Their respective concentrations in plasma were determined by gas chromatography-mass sp...

journal_title：Epilepsia

authors： Gérardin A,Dubois JP,Moppert J,Geller L

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To investigate the risk of illnesses in a cohort of patients with epilepsy and in matched nonepilepsy controls, by type and complications. METHODS:A total of 951 children and adults with idiopathic, cryptogenic, or remote symptomatic epilepsy and 904 matched controls seen in secondary and tertiary centers in e...

journal_title：Epilepsia

authors： van den Broek M,Beghi E,RESt-1 Group.

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To define the association between late-onset epilepsy (LOE) and 25-year change in cognitive performance. METHODS:The Atherosclerosis Risk in Communities (ARIC) study is a multicenter longitudinal cohort study with participants from four U.S. communities. From linked Medicare claims, we identified cases of LO...

journal_title：Epilepsia

authors： Johnson EL,Krauss GL,Walker KA,Brandt J,Kucharska-Newton A,Mosley TH Jr,Yasar S,Gottesman RF

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Epilepsy is known to result from aneurysmal subarachnoid hemorrhage (SAH). There are no population-based estimates of the absolute risk or the duration for which this risk is elevated. We have conducted a population-based study in Iceland of the risk of epilepsy after a ruptured cerebral aneurysm to address the...

journal_title：Epilepsia

authors： Olafsson E,Gudmundsson G,Hauser WA

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To validate a brief screening instrument for identifying people with epilepsy in epidemiologic or genetic studies. METHODS:We designed a nine-question screening instrument for epilepsy and administered it by telephone to individuals with medical record-documented epilepsy (lifetime history of >or=2 unprovoked ...

journal_title：Epilepsia

authors： Ottman R,Barker-Cummings C,Leibson CL,Vasoli VM,Hauser WA,Buchhalter JR

更新日期：2010-02-01 00:00:00

abstract：:We studied 36 drop seizures in 5 patients with myoclonic astatic epilepsy of early childhood (MAEE) with simultaneous split-screen video recording and polygraph. Sixteen were falling attacks and 20 were either less severe attacks exhibiting only deep head nodding or seizures equivalent to drop attacks in terms of icta...

journal_title：Epilepsia

authors： Oguni H,Fukuyama Y,Imaizumi Y,Uehara T

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:To investigate brain electrical activity in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene, and to evaluate the efficacy of low frequency deep brain stimulation (DBS) for seizure frequency reduction. METHODS:Electroencephalography (EEG), elect...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2010-09-01 00:00:00

abstract：:The literature dealing with the convulsant effects of the antidepressant drugs of the non-monoamine oxidase inhibitor variety is reviews. It is concluded that most of these drugs do lower the seizure threshold and may precipitate seizures even at normal therapeutic doses. The pathophysiology of antidepressant-induced ...

journal_title：Epilepsia

authors： Trimble M

更新日期：1978-06-01 00:00:00

abstract：PURPOSE:To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development. METHODS:The experiments were performed in postnatal day 14 (P14), P21, and P35 male Wistar rats. After stereotaxic implantation of hippocampal ...

journal_title：Epilepsia

authors： Mazarati A,Wu J,Shin D,Kwon YS,Sankar R

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Study of families containing multiple affected individuals is essential for genetic research on the epilepsies, yet practically nothing has been published about methods for identification and recruitment of families or expected participation rates. Here we describe the strategy used for data collection in a gen...

journal_title：Epilepsia

authors： Ottman R,Berenson K,Barker-Cummings C

更新日期：2005-02-01 00:00:00

abstract：:Mutations in a number of genes encoding voltage-gated sodium channels cause a variety of epilepsy syndromes in humans, including genetic (generalized) epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS, severe myoclonic epilepsy of infancy). Most of these mutations are in the SCN1A gene, and all are d...

journal_title：Epilepsia

authors： Escayg A,Goldin AL

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Our objective was to identify whether the whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from alterations in patients without FBTCS. METHODS:We dichotomized a cohort of 83 drug-resistant patients with TLE in...

journal_title：Epilepsia

authors： Sinha N,Peternell N,Schroeder GM,de Tisi J,Vos SB,Winston GP,Duncan JS,Wang Y,Taylor PN

更新日期：2021-01-21 00:00:00

abstract：:Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volu...

journal_title：Epilepsia

authors： Faught E

更新日期：2001-01-01 00:00:00

abstract：:The Asia-Oceanian region is the most populous region in the world. Although there has been substantial economic development and improvement in health services in recent years, epilepsy remains generally an underrecognized and understudied condition. To help promote research in the region, the Commission on Asian and O...

journal_title：Epilepsia

authors： Kwan P,Cabral-Lim L,D'Souza W,Jain S,Lee BI,Liao W,Lim SH,Otsuki T,Tan CT,Wantanabe M,CAOA Research Task Force.

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To assess the visual system excitability of photosensitive patients with idiopathic generalized epilepsy (IGE) with the paired-pulse flash-evoked potential (paired F-VEP) technique. METHODS:We studied 19 photosensitive patients with IGE (16 women) showing a photoparoxysmal electroencephalographic (EEG) respons...

journal_title：Epilepsia

authors： Strigaro G,Prandi P,Varrasi C,Monaco F,Cantello R

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To evaluate relationships between self-report measures of seizure severity and health-related quality of life (HRQOL) in people with refractory localization-related epilepsy. METHODS:A sample of 340 adults enrolled in a seven-center, prospective study of resective epilepsy surgery completed baseline questionna...

journal_title：Epilepsia

authors： Vickrey BG,Berg AT,Sperling MR,Shinnar S,Langfitt JT,Bazil CW,Walczak TS,Pacia S,Kim S,Spencer SS

更新日期：2000-06-01 00:00:00

abstract：:In patients with epilepsy, improvement in seizure control with treatment of coexisting obstructive sleep apnea (OSA) has been reported, but there is lack of data on the effect of continuous positive airway pressure (CPAP) compliance on seizure control in these patients. We examined the variability in seizure frequency...

journal_title：Epilepsia

authors： Vendrame M,Auerbach S,Loddenkemper T,Kothare S,Montouris G

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Brivaracetam (BRV), a selective and high-affinity synaptic vesicle protein 2A ligand, is in development as adjunctive treatment for partial-onset (focal) seizures (POS). This phase 3 study (N01358; NCT01261325) aimed to confirm the efficacy and safety/tolerability of BRV in adults (≥ 16-80 years) with POS. M...

journal_title：Epilepsia

authors： Klein P,Schiemann J,Sperling MR,Whitesides J,Liang W,Stalvey T,Brandt C,Kwan P

更新日期：2015-12-01 00:00:00

abstract：:Rufinamide (RUF) is a novel antiepileptic drug considered as second-line therapy in the treatment of Lennox-Gastaut syndrome. Treatment-emergent adverse events (AEs) have consisted mainly of drowsiness, irritability, vomiting, and loss of appetite. RUF is considered as a "weight-neutral" drug. We found clinically sign...

journal_title：Epilepsia

authors： Mourand I,Crespel A,Gelisse P

更新日期：2013-01-01 00:00:00

abstract：:Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...

journal_title：Epilepsia

authors： Mantoan Ritter L,Golshani P,Takahashi K,Dufour S,Valiante T,Kokaia M

更新日期：2014-11-01 00:00:00