Abstract:
:The literature dealing with the convulsant effects of the antidepressant drugs of the non-monoamine oxidase inhibitor variety is reviews. It is concluded that most of these drugs do lower the seizure threshold and may precipitate seizures even at normal therapeutic doses. The pathophysiology of antidepressant-induced seizures is discussed, and attention is drawn to biochemical differences in those antideprssants that have the least epileptogenic potential or may even be anticonvulsant. The clinical difficulties regarding administration of antidepressant drugs to epileptic patients are mentioned, and some practical advice is offered.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Trimble Mdoi
10.1111/j.1528-1157.1978.tb04486.xsubject
Has Abstractpub_date
1978-06-01 00:00:00pages
241-50issue
3eissn
0013-9580issn
1528-1167journal_volume
19pub_type
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