Effects of tiagabine monotherapy on abilities, adjustment, and mood.

abstract：:Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for ...

journal_title：Epilepsia

authors： Moyer JT,Gnatkovsky V,Ono T,Otáhal J,Wagenaar J,Stacey WC,Noebels J,Ikeda A,Staley K,de Curtis M,Litt B,Galanopoulou AS

更新日期：2017-11-01 00:00:00

abstract：:The effects of phenytoin (PHT) on the spontaneous activity of cerebellar Purkinje cells and the drug serum levels have been examined following both intravenous and intraperitoneal administration in rats. Purkinje cell activity was assessed by on-line computer analysis of interspike interval distributions. PHT levels w...

journal_title：Epilepsia

authors： Latham A,Paul DH

更新日期：1980-12-01 00:00:00

abstract：OBJECTIVE:Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustai...

journal_title：Epilepsia

authors： Taub KS,Kessler SK,Bergqvist AG

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To describe the natural history of electroencephalography (EEG) changes in patients with benign epilepsy with centrotemporal spikes (BECTS) over 1 year. METHODS:Centrotemporal spikes were visually evaluated based on 24-h ambulatory EEG studies to determine the total, left, right, and bilateral centrotemporal...

journal_title：Epilepsia

authors： Tenney JR,Glauser T,Altaye M,Szaflarski JP,Spencer C,Morita D,Vannest J

更新日期：2016-05-01 00:00:00

abstract：:Eslicarbazepine acetate (ESL) is a novel once-daily antiepileptic drug (AED) approved in Europe since 2009 that was found to be efficacious and well tolerated in a phase III clinical program in adult patients with partial onset seizures previously not controlled with treatment with one to three AEDs, including carbama...

journal_title：Epilepsia

authors： Bialer M,Soares-da-Silva P

更新日期：2012-06-01 00:00:00

abstract：:Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy. CLB has an excellent safety record. As with all benzodiazepines used for treating epilepsy, sedation and withdrawal effects, together with the development of tolerance, limit its useful...

journal_title：Epilepsia

authors： Schmidt D

更新日期：1994-01-01 00:00:00

abstract：:Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies ha...

journal_title：Epilepsia

authors： Nicita F,Ruggieri M,Polizzi A,Mauceri L,Salpietro V,Briuglia S,Papetti L,Ursitti F,Grosso S,Tarani L,Segni M,Savasta S,Parisi P,Verrotti A,Spalice A

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:To determine the lateralizing value of the clinical manifestations of seizures in patients with temporal lobe epilepsy (TLE), we made a retrospective videotape analysis of complex partial seizures (CPS) in 55 patients who underwent temporal lobectomy and were seizure-free postoperatively for >2 years. METHODS:...

journal_title：Epilepsia

authors： Marks WJ Jr,Laxer KD

更新日期：1998-07-01 00:00:00

abstract：:We report on the cognitive-behavioral treatment of a 12-year-old boy with photogenic partial seizures with secondary generalization who had developed phobic avoidant behavior toward all kinds of situations with potential photostimulation, leading to serious impairments of life quality. Based on a behavioral analysis o...

journal_title：Epilepsia

authors： Noeker M,Haverkamp F

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To assess the usefulness of an early postictal EEG in neurologically normal children with complex febrile seizures. METHODS:We conducted a retrospective chart review of all neurologically normal children who were hospitalized over a period of 2.5 years after complex febrile seizures, and had an EEG up to 1 wee...

journal_title：Epilepsia

authors： Maytal J,Steele R,Eviatar L,Novak G

更新日期：2000-02-01 00:00:00

abstract：:Four groups of pregnant rats were used to study the effects of dietary supplements of folic acid (FA) alone or a mixture of FA, vitamins (Vit), and amino acids (AA) on the teratogenic effects of phenytoin (PHT). Groups A, B, and C received intraperitoneal (i.p.) injections of high-dose (75 mg/kg/day) phenytoin (PHT) b...

journal_title：Epilepsia

authors： Zhu MX,Zhou SS

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:To evaluate the natural history and mortality of chronic epilepsy in an untreated prevalence cohort of people with epilepsy (PWE) in a rural area of Bolivia. METHODS:During 1994-1996 we carried out an epidemiologic survey in a sample of 9,995 subjects in the Cordillera province. At the end of the survey we ide...

journal_title：Epilepsia

authors： Nicoletti A,Sofia V,Vitale G,Bonelli SI,Bejarano V,Bartalesi F,Tran DS,Preux PM,Zappia M,Bartoloni A

更新日期：2009-10-01 00:00:00

abstract：:Twenty-seven epileptic patients, most from low socioeconomic groups and aged 15-54 years, were studied for effects of prolonged anticonvulsant medication. They had received the usual doses of phenobarbitone and diphenylhydantoin (PHT) regularly for 3-32 years, with control of seizures, and had not taken any B-vitamins...

journal_title：Epilepsia

authors： Dastur DK,Dave UP

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...

journal_title：Epilepsia

authors： Eisermann MM,Ville D,Soufflet C,Plouin P,Chiron C,Dulac O,Kaminska A

更新日期：2006-06-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional c...

journal_title：Epilepsia

authors： Kanyo R,Wang CK,Locskai LF,Li J,Allison WT,Kurata HT

更新日期：2020-08-01 00:00:00

abstract：:We examined postoperative changes in the memory function of 68 people with unilateral hippocampal sclerosis (HS) who underwent epilepsy surgery and had no previous clinical memory impairments. One in four with right HS (RHS) and one in five with left HS (LHS) in our sample of 323 people with unilateral HS performed wi...

journal_title：Epilepsia

authors： Baxendale S,Thompson PJ,Sander JW

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

journal_title：Epilepsia

authors： Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To evaluate the effect of stress on seizure frequency in childhood epilepsy, and to assess possible differences between children in whom seizures are precipitated by stress and those in whom they are not. METHODS:Parents or caregivers of children with active epilepsy (aged 2-16 years) were sent questionnaires ...

journal_title：Epilepsia

authors： van Campen JS,Jansen FE,Steinbusch LC,Joëls M,Braun KP

更新日期：2012-09-01 00:00:00

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：:Mutations of the SCN1A subunit of the sodium channel is a cause of genetic epilepsy with febrile seizures plus (GEFS(+) ) in multiplex families and accounts for 70-80% of Dravet syndrome (DS). DS cases without SCN1A mutation inherited have predicted SCN9A susceptibility variants, which may contribute to complex inheri...

journal_title：Epilepsia

authors： Mulley JC,Hodgson B,McMahon JM,Iona X,Bellows S,Mullen SA,Farrell K,Mackay M,Sadleir L,Bleasel A,Gill D,Webster R,Wirrell EC,Harbord M,Sisodiya S,Andermann E,Kivity S,Berkovic SF,Scheffer IE,Dibbens LM

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Polymicrogyria (PMG) is an epileptogenic malformation of cortical development. We describe the clinical epilepsy and imaging features of a large cohort with PMG-related epilepsy. METHODS:Participants were recruited through the Epilepsy Phenome/Genome Project, a multicenter collaborative effort to collect detai...

journal_title：Epilepsia

authors： Shain C,Ramgopal S,Fallil Z,Parulkar I,Alongi R,Knowlton R,Poduri A,EPGP Investigators.

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Children with rolandic spikes may or may not have seizures, ranging from benign rolandic epilepsy to severe atypical rolandic epilepsy. We investigated whether ripples (80-250 Hz), superimposed on rolandic spikes in surface electroencephalography (EEG), can differentiate between different entities. METHODS:I...

journal_title：Epilepsia

authors： van Klink NE,van 't Klooster MA,Leijten FS,Jacobs J,Braun KP,Zijlmans M

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug-resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR...

journal_title：Epilepsia

authors： Ghosh C,Hossain M,Solanki J,Najm IM,Marchi N,Janigro D

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To define the phenotypic spectrum of phosphatidylinositol glycan class A protein (PIGA)-related congenital disorder of glycosylation (PIGA-CDG) and evaluate genotype-phenotype correlations. METHODS:Our cohort encompasses 40 affected males with a pathogenic PIGA variant. We performed a detailed phenotypic ass...

journal_title：Epilepsia

authors： Bayat A,Knaus A,Pendziwiat M,Afenjar A,Barakat TS,Bosch F,Callewaert B,Calvas P,Ceulemans B,Chassaing N,Depienne C,Endziniene M,Ferreira CR,Moura de Souza CF,Freihuber C,Ganesan S,Gataullina S,Guerrini R,Guerrot AM,

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...

journal_title：Epilepsia

authors： Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To prospectively investigate the incidence of interictal psychoses of epilepsy patients, and make a comparison between those with interictal psychoses and patients with schizophrenia in respect to their responses to antipsychotic drugs, as well as psychotic states. METHODS:We undertook a two-part prospective i...

journal_title：Epilepsia

authors： Tadokoro Y,Oshima T,Kanemoto K

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...

journal_title：Epilepsia

authors： Musto A,Bazan NG

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are currently unavailable for mobile health (mHealth) in epilepsy devices and related applications. As a result, despite expansive growth of new digital services for people with epilepsy, information collected is often not interoperable or directly comparable. We aim to correct thi...

journal_title：Epilepsia

authors： Goldenholz DM,Moss R,Jost DA,Crone NE,Krauss G,Picard R,Caborni C,Cavazos JE,Hixson J,Loddenkemper T,Salazar TD,Lubbers L,Harte-Hargrove LC,Whittemore V,Duun-Henriksen J,Dolan E,Kasturia N,Oberemk M,Cook MJ,Lehmkuhl

更新日期：2018-05-01 00:00:00

abstract：:In 45 patients suffering from secondary generalized epilepsy, we have recorded 239 drop seizures both by radio-telemetered EEG/split-screen video taping and polygraphically. Twenty of these patients had pure tonic drop seizures. Nine patients each had myoclonic-atonic or pure atonic seizures, whereas seven had slow fa...

journal_title：Epilepsia

authors： Egli M,Mothersill I,O'Kane M,O'Kane F

更新日期：1985-09-01 00:00:00