Abstract:
:Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy. CLB has an excellent safety record. As with all benzodiazepines used for treating epilepsy, sedation and withdrawal effects, together with the development of tolerance, limit its usefulness. Recent efforts to prevent or reverse tolerance with intermittent administration of CLB or periodic injection of a benzodiazepine antagonist, flumazenil, are encouraging and justify further investigations.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Schmidt Ddoi
10.1111/j.1528-1157.1994.tb05979.xsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
S92-5eissn
0013-9580issn
1528-1167journal_volume
35 Suppl 5pub_type
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