Sudden unexpected death in epilepsy: impact on clinical practice.

abstract：OBJECTIVE:Whether magnetic resonance imaging (MRI) is informative in febrile seizures (FS) is unknown. We undertook a study to determine the frequency of MRI-detected brain abnormalities and to evaluate their association with FS type and with specific features of complex FS. METHODS:A prospective cohort study, from 19...

journal_title：Epilepsia

authors： Hesdorffer DC,Chan S,Tian H,Allen Hauser W,Dayan P,Leary LD,Hinton VJ

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development. METHODS:The experiments were performed in postnatal day 14 (P14), P21, and P35 male Wistar rats. After stereotaxic implantation of hippocampal ...

journal_title：Epilepsia

authors： Mazarati A,Wu J,Shin D,Kwon YS,Sankar R

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To describe the semiologic features of aggressive behaviors observed in human epileptic seizures with particular reference to the act of biting a conspecific. METHODS:We analyzed the biting behavior (BB) and other aggressive gestures occurring in a group of 11 patients retrospectively selected from >1,000 pati...

journal_title：Epilepsia

authors： Tassinari CA,Tassi L,Calandra-Buonaura G,Stanzani-Maserati M,Fini N,Pizza F,Sartori I,Michelucci R,Lo Russo G,Meletti S

更新日期：2005-05-01 00:00:00

abstract：:Advanced variant detection in genes underlying risk of sudden unexpected death in epilepsy (SUDEP) can uncover extensive epistatic complexity and improve diagnostic accuracy of epilepsy-related mortality. However, the sensitivity and clinical utility of diagnostic panels based solely on established cardiac arrhythmia ...

journal_title：Epilepsia

authors： Klassen TL,Bomben VC,Patel A,Drabek J,Chen TT,Gu W,Zhang F,Chapman K,Lupski JR,Noebels JL,Goldman AM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can ter...

journal_title：Epilepsia

authors： Van Gompel JJ,Bower MR,Worrell GA,Stead M,Chang SY,Goerss SJ,Kim I,Bennet KE,Meyer FB,Marsh WR,Blaha CD,Lee KH

更新日期：2014-02-01 00:00:00

abstract：:Nonepileptic seizures (NES) are common and are often diagnosed at epilepsy centers by video-EEG recording of both spontaneous and suggestion-induced episodes, but no study has evaluated provocative testing in a general seizure population. We studied consecutive patients with a tentative diagnosis of epilepsy using sal...

journal_title：Epilepsia

authors： Bazil CW,Kothari M,Luciano D,Moroney J,Song S,Vasquez B,Weinreb HJ,Devinsky O

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:To conduct the first randomized trial on classical and medium-chain triglyceride (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. METHODS:One hundred forty-five children with intractable epilepsy were randomized to receive a classical or an MCT diet. Seizure ...

journal_title：Epilepsia

authors： Neal EG,Chaffe H,Schwartz RH,Lawson MS,Edwards N,Fitzsimmons G,Whitney A,Cross JH

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Most people in the world with epilepsy are untreated with antiepileptic drugs (AEDs). In some developing countries, this is because treatment facilities are unavailable or difficult to access. It has even been suggested that indigenous health systems threaten the prospect of the global control of epilepsy with ...

journal_title：Epilepsia

authors： Pal DK,Das T,Sengupta S,Chaudhury G

更新日期：2002-08-01 00:00:00

abstract：:The diagnostic goals in nonsurgical (conservative) epileptology differ from presurgical diagnostic aims. The resulting development of diagnostic methods in a tertiary-level epilepsy center is shown and the major technical and organizational consequences of this difference for diagnostic long-term monitoring (LTM) as o...

journal_title：Epilepsia

authors： Ried S,Hilfiker P,Mothersill IW,Krämer G

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:We analyzed a large group of patients investigated for suspected seizures to test whether gender or side are important factors in the origins of hippocampal sclerosis (HS). METHODS:We studied 996 consecutive patients (48% men, 52% women) by using standard hippocampal T2-relaxometry methods. RESULTS:HS was ass...

journal_title：Epilepsia

authors： Briellmann RS,Jackson GD,Mitchell LA,Fitt GJ,Kim SE,Berkovic SF

更新日期：1999-12-01 00:00:00

abstract：:The anticonvulsant hypersensitivity syndrome (AHS) is an idiosyncratic immunologic reaction to certain anticonvulsant medications, in which internal organ involvement may lead to fatal multisystemic failure. This syndrome has been associated with the use of aromatic ring-containing agents such as phenytoin, carbamazep...

journal_title：Epilepsia

authors： Cumbo-Nacheli G,Weinberger J,Alkhalil M,Thati N,Baptist AP

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To estimate the incidence and mortality associated with first unprovoked seizure or newly diagnosed epilepsy in a low-income, predominantly Hispanic community in Northern Manhattan, New York City. METHODS:We performed a population-based study to determine the incidence of first unprovoked seizure or newly diag...

journal_title：Epilepsia

authors： Benn EK,Hauser WA,Shih T,Leary L,Bagiella E,Dayan P,Green R,Andrews H,Thurman DJ,Hesdorffer DC

更新日期：2008-08-01 00:00:00

abstract：:We present a 4-year-old girl with profound global developmental delay and refractory epilepsy characterized by multiple seizure types (partial complex with secondary generalization, tonic, myoclonic, and atypical absence). Her seizure semiology did not fit within a specific epileptic syndrome. Despite a broad metaboli...

journal_title：Epilepsia

authors： Venkateswaran S,Myers KA,Smith AC,Beaulieu CL,Schwartzentruber JA,FORGE Canada Consortium.,Majewski J,Bulman D,Boycott KM,Dyment DA

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:  Vagus nerve stimulation (VNS) provides partial relief of medically refractory partial seizures in a subset of patients. The optimal pattern of stimulation and the mechanism of the antiseizure effects are uncertain. Establishing the efficacy of VNS in an animal model of epilepsy would provide an experimental p...

journal_title：Epilepsia

authors： Alexander GM,McNamara JO

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:This study was designed to quantify the relation between expressions of NMDA receptor (NMDAR) subunits (1 and 2A/B) and the epileptogenicity in human focal cortical dysplasia. METHODS:Immunoblotting and immunoprecipitation were used to quantify these receptor subunits in tissue resected from EEG-verified epile...

journal_title：Epilepsia

authors： Mikuni N,Babb TL,Ying Z,Najm I,Nishiyama K,Wylie C,Yacubova K,Okamoto T,Bingaman W

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To assess the long-term evolution of Unverricht-Lundborg disease (ULD), especially concerning myoclonus, seizures, and EEG characteristics. METHODS:We retrospectively evaluated 20 patients (six women, 14 men; mean age, 37.9 years; range, 26-53 years) with ULD who had been closely followed up since the onset of...

journal_title：Epilepsia

authors： Magaudda A,Ferlazzo E,Nguyen VH,Genton P

更新日期：2006-05-01 00:00:00

abstract：:We set out to review the extent to which molecular karyotyping has overtaken conventional cytogenetics in applications related to epilepsy. Multiplex ligase-dependent probe amplification (MLPA) targeted to predetermined regions such as SCN1A and KCNQ2 has been effectively applied over the last half a decade, and oligo...

journal_title：Epilepsia

authors： Mulley JC,Mefford HC

更新日期：2011-03-01 00:00:00

abstract：:The feasibility of automated detection of cortical-onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in nine subjects with pharmaco...

journal_title：Epilepsia

authors： Osorio I,Frei MG,Lozano AM,Wennberg R

更新日期：2015-10-01 00:00:00

abstract：:It is unclear whether the outcome of status epilepticus (SE), a neurological emergency associated with high mortality and morbidity, has changed over the past decade. We investigated the difference in prognosis (mortality, functional status at discharge) after adult SE episodes in a large registry between 2 time point...

journal_title：Epilepsia

authors： Fatuzzo D,Novy J,Rossetti AO

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Pathogenic variants of KCNQ2, which encode a potassium channel subunit, cause either benign (familial) neonatal epilepsy-B(F)NE)-or KCNQ2 encephalopathy (KCNQ2 DEE). We examined the characteristics of KCNQ2 variants. METHODS:KCNQ2 pathogenic variants were collected from in-house data and two large disease da...

journal_title：Epilepsia

authors： Goto A,Ishii A,Shibata M,Ihara Y,Cooper EC,Hirose S

更新日期：2019-09-01 00:00:00

abstract：:The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy here refer...

journal_title：Epilepsia

authors： Bernard C

更新日期：2020-10-16 00:00:00

abstract：PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

journal_title：Epilepsia

authors： Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...

journal_title：Epilepsia

authors： Nissen IA,Stam CJ,Reijneveld JC,van Straaten IE,Hendriks EJ,Baayen JC,De Witt Hamer PC,Idema S,Hillebrand A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Our goal was to study the anticonvulsant action of tiagabine (TGB) at different levels of brain maturation in rats. METHODS:Wistar rats in five age groups (7, 12, 18, 25, and 90 days old) were injected intraperitoneally with TGB at doses of 0.5-32 mg/kg. Thirty minutes later, motor seizures were induced by the...

journal_title：Epilepsia

authors： Haugvicová R,Skutová M,Kubová H,Suchomelová L,Mares P

更新日期：2000-11-01 00:00:00

abstract：:Seizures, epilepsy, and alcohol are complexly interrelated. Although it is commonly perceived that patients with epilepsy experience problems with seizure control if they use alcohol, this is not confirmed by the few experimental studies that have tested the hypothesis. The last 30 years have emphasized the role of wi...

journal_title：Epilepsia

authors： Hauser WA,Ng SK,Brust JC

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric...

journal_title：Epilepsia

authors： Powell KL,Tang H,Ng C,Guillemain I,Dieuset G,Dezsi G,Çarçak N,Onat F,Martin B,O'Brien TJ,Depaulis A,Jones NC

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The low glycemic index treatment (LGIT) is a high fat, limited carbohydrate diet used in the treatment of epilepsy. The purpose of this study was to assess the efficacy and tolerability of the LGIT for the treatment of refractory seizures in pediatric patients with Angelman syndrome. METHODS:A pediatric Angelm...

journal_title：Epilepsia

authors： Thibert RL,Pfeifer HH,Larson AM,Raby AR,Reynolds AA,Morgan AK,Thiele EA

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Identification of patients at risk of developing epilepsy before the first spontaneous seizure may promote the development of preventive treatment providing opportunity to stop or slow down the disease. METHODS:As development of novel radiotracers and on-site setup of existing radiotracers is highly time-con...

journal_title：Epilepsia

authors： Bascuñana P,Gendron T,Sander K,Jahreis I,Polyak A,Ross TL,Bankstahl M,Arstad E,Bankstahl JP

更新日期：2019-11-01 00:00:00

abstract：:We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given...

journal_title：Epilepsia

authors： Sawaishi Y,Yano T,Enoki M,Takada G

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic in...

journal_title：Epilepsia

authors： Ung H,Davis KA,Wulsin D,Wagenaar J,Fox E,McDonnell JJ,Patterson N,Vite CH,Worrell G,Litt B

更新日期：2016-12-01 00:00:00