Abstract:
:We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given the pharmacologic mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Sawaishi Y,Yano T,Enoki M,Takada Gdoi
10.1046/j.1528-1157.2002.25301.xsubject
Has Abstractpub_date
2002-02-01 00:00:00pages
201-4issue
2eissn
0013-9580issn
1528-1167pii
epi25301journal_volume
43pub_type
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