Abstract:
PURPOSE:Vigabatrin (VGB) and lamotrigine (LTG) are two new antiepileptic drugs (AEDs) with different mechanisms of action for treatment of refractory epilepsies. Previous reports have indicated efficacy of both drugs in a number of epileptic syndromes. METHODS:We compared these new AEDs drugs to determine their respective efficacy against different types of epileptic syndrome and to develop a rational approach to their use. We reviewed the charts of 105 children, with partial and generalized epilepsies. RESULTS:VGB was to be significantly more effective in children with partial epilepsies, and LTG was more effective in those with generalized epilepsies. CONCLUSIONS:VGB and LTG have different therapeutic profiles. Combination treatment with the two drugs may represent rational polytherapy for patients with epilepsy resistant to treatment with either drug alone or as add-on to other AED treatment.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Bélanger S,Coulombe G,Carmant Ldoi
10.1111/j.1528-1157.1998.tb01184.xsubject
Has Abstractpub_date
1998-08-01 00:00:00pages
878-83issue
8eissn
0013-9580issn
1528-1167journal_volume
39pub_type
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