Microstructural integrity of early- versus late-myelinating white matter tracts in medial temporal lobe epilepsy.

abstract：:Epilepsy syndromes occupy an important position in the current nosology of the epilepsies, describing and classifying seizure disorders with shared clinical and EEG features. Increasingly, this schema is being refined as new information becomes available and our understanding of etiology and presentation of each syndr...

journal_title：Epilepsia

authors： Duchowny M,Harvey AS

更新日期：1996-01-01 00:00:00

abstract：:During a 10-year period, 203 traffic accidents were suspected of being caused by epilepsy; 155 of them definitely caused by seizures were selected for study. The seizures of 75% were psychomotor; in 12% the seizure was the first, and only 4% of the rest had reported that they had epilepsy when they applied for a licen...

journal_title：Epilepsia

authors： van der Lugt PJ

更新日期：1975-12-01 00:00:00

abstract：:Dogs with spontaneous diseases can exhibit a striking similarity in etiology, clinical manifestation, and disease course when compared to human patients. Therefore, dogs are intensely discussed as a translational model of human disease. In particular, genetic studies in selected dog breeds serve as an excellent tool t...

journal_title：Epilepsia

authors： Potschka H,Fischer A,von Rüden EL,Hülsmeyer V,Baumgärtner W

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). METHODS:We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investiga...

journal_title：Epilepsia

authors： Kobayashi E,D'Agostino MD,Lopes-Cendes I,Andermann E,Dubeau F,Guerreiro CA,Schenka AA,Queiroz LS,Olivier A,Cendes F,Andermann F

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:Our goal was to study the anticonvulsant action of tiagabine (TGB) at different levels of brain maturation in rats. METHODS:Wistar rats in five age groups (7, 12, 18, 25, and 90 days old) were injected intraperitoneally with TGB at doses of 0.5-32 mg/kg. Thirty minutes later, motor seizures were induced by the...

journal_title：Epilepsia

authors： Haugvicová R,Skutová M,Kubová H,Suchomelová L,Mares P

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. METHODS:We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. RESULTS:We analyzed retrospectiv...

journal_title：Epilepsia

authors： Barba C,Cross JH,Braun K,Cossu M,Klotz KA,De Masi S,Perez Jiménez MA,Gaily E,Specchio N,Cabral P,Toulouse J,Dimova P,Battaglia D,Freri E,Consales A,Cesaroni E,Tarta-Arsene O,Gil-Nagel A,Mindruta I,Di Gennaro G,Giu

更新日期：2020-02-01 00:00:00

abstract：:Study of patients with temporal lobe epilepsy and generalized epilepsy revealed no overall seizure type differences, nor overall age-at-onset effects, on MMPI measures of psychopathology. However, statistically significant interactions between seizure type and age at onset were obtained on several MMPI measures, and s...

journal_title：Epilepsia

authors： Hermann BP,Schwartz MS,Karnes WE,Vahdat P

更新日期：1980-02-01 00:00:00

abstract：PURPOSE:Management of seizures in learning disabled people is challenging. This prospective study explored the efficacy and tolerability of adjunctive topiramate (TPM) in patients with learning disability and refractory epilepsy attending a single centre. METHODS:Sixty-four patients (36 men, 28 women, aged 16-65 years...

journal_title：Epilepsia

authors： Kelly K,Stephen LJ,Sills GJ,Brodie MJ

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:This study was designed to quantify the relation between expressions of NMDA receptor (NMDAR) subunits (1 and 2A/B) and the epileptogenicity in human focal cortical dysplasia. METHODS:Immunoblotting and immunoprecipitation were used to quantify these receptor subunits in tissue resected from EEG-verified epile...

journal_title：Epilepsia

authors： Mikuni N,Babb TL,Ying Z,Najm I,Nishiyama K,Wylie C,Yacubova K,Okamoto T,Bingaman W

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development. METHODS:The experiments were performed in postnatal day 14 (P14), P21, and P35 male Wistar rats. After stereotaxic implantation of hippocampal ...

journal_title：Epilepsia

authors： Mazarati A,Wu J,Shin D,Kwon YS,Sankar R

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To explore the correlations between treatment modalities and selected disease parameters with outcome in febrile infection-related epilepsy syndrome (FIRES), a catastrophic epileptic encephalopathy with a yet undefined etiology. METHODS:We conducted a retrospective multicenter study on children who had been in...

journal_title：Epilepsia

authors： Kramer U,Chi CS,Lin KL,Specchio N,Sahin M,Olson H,Nabbout R,Kluger G,Lin JJ,van Baalen A

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Previously we demonstrated that L-(+)-beta-hydroxybutyrate (L-BHB), acetoacetate (ACA), acetone, and dibenzylamine (DBA) were anticonvulsant in an audiogenic seizure-susceptible model, and that DBA was a bioactive contaminant identified in commercial lots of L-BHB. In the present study, we asked whether these e...

journal_title：Epilepsia

authors： Donevan SD,White HS,Anderson GD,Rho JM

更新日期：2003-10-01 00:00:00

abstract：:A variety of experimental paradigms have been utilized to study verbal learning and memory ability in patients with epilepsy. One commonly used paradigm, the free recall of a list(s) of related or unrelated words, has revealed a variety of performance anomalies in patients with complex partial seizures (CPS) of tempor...

journal_title：Epilepsia

authors： Hermann BP,Wyler AR,Richey ET,Rea JM

更新日期：1987-09-01 00:00:00

abstract：:The Commission on Classification and Terminology and the Commission on Epidemiology of the International League Against Epilepsy (ILAE) have charged a Task Force to revise concepts, definition, and classification of status epilepticus (SE). The proposed new definition of SE is as follows: Status epilepticus is a condi...

journal_title：Epilepsia

authors： Trinka E,Cock H,Hesdorffer D,Rossetti AO,Scheffer IE,Shinnar S,Shorvon S,Lowenstein DH

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Ictal single-photon emission computed tomography (SPECT) may help localize the seizure-onset zone (SOZ) by detecting changes in regional cerebral blood flow induced by epileptic discharges. This imaging method also reveals hyperperfusions in areas of seizure propagation, including the hemisphere contralateral t...

journal_title：Epilepsia

authors： Huberfeld G,Habert MO,Clemenceau S,Maksud P,Baulac M,Adam C

更新日期：2006-01-01 00:00:00

abstract：:We report the clinical presentation, neuroradiologic characteristics, and detailed histopathologic findings in a unique case of drug-resistant focal epilepsy due to sublobar dysplasia (SLD), treated successfully by resection of the malformed cortex. Histopathology with leptomeningeal and subcortical heterotopia, distu...

journal_title：Epilepsia

authors： Tuxhorn I,Woermann FG,Pannek HW,Hans VH

更新日期：2009-12-01 00:00:00

abstract：:The possible effect of in utero antiepileptic drug (AED) exposure on the incidence of spontaneous abortion was evaluated among pregnancies of women with epilepsy and the wives of men with epilepsy. The proportion of pregnancy outcomes terminating in spontaneous abortion, the gestational age-specific rates of spontaneo...

journal_title：Epilepsia

authors： Annegers JF,Baumgartner KB,Hauser WA,Kurland LT

更新日期：1988-07-01 00:00:00

abstract：:Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing response...

journal_title：Epilepsia

authors： Eftekhari S,Mehvari Habibabadi J,Najafi Ziarani M,Hashemi Fesharaki SS,Gharakhani M,Mostafavi H,Joghataei MT,Beladimoghadam N,Rahimian E,Hadjighassem MR

更新日期：2013-01-01 00:00:00

abstract：:The effects of seizures on the hypocretin/orexin system have not yet been investigated in epileptic patients. The present study aimed to assay hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized tonic-clonic (GTC) seizures. Study groups consisted of 21 patients after GTC seizures and 19 control...

journal_title：Epilepsia

authors： Rejdak K,Papuć E,Grieb P,Stelmasiak Z

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To address concerns about possible increases in rates of sudden unexplained death (SUD) after use of new anticonvulsants, more information on the rate of SUD among subjects with refractory epilepsy is needed to provide a comparison. METHODS:We conducted a study to estimate the incidence of SUD among subjects y...

journal_title：Epilepsia

authors： Derby LE,Tennis P,Jick H

更新日期：1996-10-01 00:00:00

abstract：:Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...

journal_title：Epilepsia

authors： Yasiry Z,Shorvon SD

更新日期：2012-12-01 00:00:00

abstract：:Sleep and epilepsy are interrelated. Understanding the relationship between epilepsy and sleep is important for optimizing management of the epilepsy patient in several ways. First, sleep modulates the expression of epileptic seizures and interictal epileptiform discharges. Second, epilepsy and its treatment influence...

journal_title：Epilepsia

authors： Malow BA

更新日期：2007-01-01 00:00:00

abstract：:The objectives of this study were to investigate the lifetime prevalence of epileptic seizures in a population with acute intermittent porphyria (AIP) and to characterize the seizures and the seizure-triggering factors. A letter was sent to all patients with known AIP in Sweden registered at the National Porphyria Cen...

journal_title：Epilepsia

authors： Bylesjö I,Forsgren L,Lithner F,Boman K

更新日期：1996-03-01 00:00:00

abstract：:Cortical dysplasia (CD, also known as malformations of cortical development) are the pathological substrates in a large percentage of patients with pharmacoresistant epilepsy who may be amenable to surgical treatment. Therefore, research on the mechanisms of dysplastic lesion formation and epileptogenicity is of param...

journal_title：Epilepsia

authors： Najm IM,Tilelli CQ,Oghlakian R

更新日期：2007-01-01 00:00:00

abstract：:We examined EEG findings from an ongoing study of 347 children with a first unprovoked seizure. EEGs were available in 321 (93%), and 135 (42%) had an abnormal EEG. EEG abnormalities included focal spikes (n = 77), generalized spike and wave discharges (n = 28), slowing (n = 43), and nonspecific abnormalities (n = 7)....

journal_title：Epilepsia

authors： Shinnar S,Kang H,Berg AT,Goldensohn ES,Hauser WA,Moshé SL

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To compare surgical outcome in mesial temporal lobe epilepsy (MTLE) patients with unilateral hippocampal sclerosis (MTLE-HS) who had or did not have preoperative video-electroencephalographic monitoring (VEEG). METHODS:A prospective study was undertaken with 166 consecutive pharmacoresistant unilateral MTLE-...

journal_title：Epilepsia

authors： Alvim MKM,Morita ME,Yasuda CL,Damasceno BP,Lopes TM,Coan AC,Ghizoni E,Tedeschi H,Cendes F

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:The concordance of lateralized EEG postictal polymorphic delta activity (PPDA) to the side of seizure origin in temporal lobe epilepsy (TLE) has received limited study. Our objective was to study the lateralizing value of PPDA in patients with documented TLE. METHODS:A cohort of consecutive adults with TLE, de...

journal_title：Epilepsia

authors： Jan MM,Sadler M,Rahey SR

更新日期：2001-03-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imagi...

journal_title：Epilepsia

authors： Muhlhofer W,Tan YL,Mueller SG,Knowlton R

更新日期：2017-05-01 00:00:00

abstract：:The effect od dipropylacetic acid (DPA; Depakine) on the bemegride-induced convulsive threshold was investigated in alert cats. Forty-five min after DPA 200 mg/kg, s.c., no significant effect was obtained; 5 min after the same dose iv., protection from bemegride-induced seizures was pronounced. DPA did not decrease fo...

journal_title：Epilepsia

authors： van Duijn H,Beckmann MK

更新日期：1975-03-01 00:00:00

abstract：OBJECTIVE:Among children with epilepsy, to develop and evaluate a model to predict emergency department (ED) use, an indicator of poor disease control and/or poor access to care. METHODS:We used electronic health record data from 2013 to predict ED use in 2014 at 2 centers, benchmarking predictive performance against ...

journal_title：Epilepsia

authors： Grinspan ZM,Patel AD,Hafeez B,Abramson EL,Kern LM

更新日期：2018-01-01 00:00:00