NMDA-receptors 1 and 2A/B coassembly increased in human epileptic focal cortical dysplasia.

abstract：OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...

journal_title：Epilepsia

authors： Sánchez Fernández I,Gaínza-Lein M,Barcia Aguilar C,Amengual-Gual M,Loddenkemper T

更新日期：2020-10-01 00:00:00

abstract：:In a double-blind, randomized, parallel-group trial, we compared topiramate (TPM) with placebo as add-on therapy in patients with refractory partial epilepsy. TPM was titrated either to the target dosage of 800 mg/ day [400 mg twice daily (b.i.d)] or to the maximal tolerated dose if lower. Twenty-eight (28) patients w...

journal_title：Epilepsia

authors： Ben-Menachem E,Henriksen O,Dam M,Mikkelsen M,Schmidt D,Reid S,Reife R,Kramer L,Pledger G,Karim R

更新日期：1996-06-01 00:00:00

abstract：:Determining a prognosis for functional recovery after prolonged status epilepticus can be difficult. Prior case studies have shown that despite seizure control, functional outcomes are typically poor unless a reversible cause is identified. Herein we present a case of idiopathic status epilepticus with a surprisingly ...

journal_title：Epilepsia

authors： Standley K,Abdulmassih R,Benbadis S

更新日期：2012-01-01 00:00:00

abstract：:In developed countries, the incidence of epilepsy is 50-100 cases per 100,000 population per year and the prevalence is approximately 5 to 8 cases per 1,000 population. Epilepsy is by far the most prevalent serious neurologic condition. Mortality rates in epilepsy are two to four times those found in matched nonepilep...

journal_title：Epilepsia

authors： Shorvon SD

更新日期：1996-01-01 00:00:00

abstract：:Impaired cortical inhibition may be involved in epileptogenic mechanisms. In a positron-emission tomography (PET) study, we demonstrated a reduction of the cortical benzodiazepine (BZD) receptor density in the epileptic foci of patients with partial epileptic seizures. In the present study, we used the same method in ...

journal_title：Epilepsia

authors： Savic I,Widen L,Thorell JO,Blomqvist G,Ericson K,Roland P

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:High-dose i.v. opioids (e.g., alfentanil, 50 microg/kg bolus) are known to increase the intraoperative reading of epileptiform activity during epilepsy surgery (ES), thereby facilitating localization of the epileptogenic zone (i.e., the site of ictal onset and initial seizure propagation). However, this phenome...

journal_title：Epilepsia

authors： Wass CT,Grady RE,Fessler AJ,Cascino GD,Lozada L,Bechtle PS,Marsh WR,Sharbrough FW,Schroeder DR

更新日期：2001-10-01 00:00:00

abstract：:A number of factors have contributed to improvements in the care of epilepsy during the past decade, including the International League Against Epilepsy classifications, therapeutic antiepileptic drug (AED) monitoring and the concept of monotherapy, new AEDs with novel mechanisms of action, and new insights into etiol...

journal_title：Epilepsia

authors： Gram L

更新日期：1995-01-01 00:00:00

abstract：:Quantitative evidence of hippocampal atrophy has been correlated with site of seizure onset, hippocampal neuronal loss, and seizure relief after resection. Most studies have quantified hippocampal atrophy using ratios or differences between right and left hippocampal values. However, bilateral hippocampal atrophy may ...

journal_title：Epilepsia

authors： King D,Spencer SS,McCarthy G,Luby M,Spencer DD

更新日期：1995-09-01 00:00:00

abstract：:Sudden unexplained death syndrome (SUDS) accounts for about 10% of deaths in patients with epilepsy. It is associated with subtherapeutic postmortem serum antiepileptic drug (AED) levels but no anatomic cause of death on autopsy. The mechanisms of death are not known. We investigated 44 cases of SUDS for details of se...

journal_title：Epilepsia

authors： Earnest MP,Thomas GE,Eden RA,Hossack KF

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients. METHODS:In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 wi...

journal_title：Epilepsia

authors： Rolinski R,Austermuehle A,Wiggs E,Agrawal S,Sepeta LN,Gaillard WD,Zaghloul KA,Inati SK,Theodore WH

更新日期：2019-03-01 00:00:00

abstract：:Scrub typhus is an emerging infection, and there is little information about status epilepticus (SE) in scrub typhus. We report the clinical spectrum and outcome of SE in scrub typhus. In a 3-year prospective hospital-based observational study, all scrub typhus patients with SE were included. Scrub typhus was diagnose...

journal_title：Epilepsia

authors： Kalita J,Mani VE,Bhoi SK,Misra UK

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Several experimental paradigms of seizure induction that produce epilepsy as a consequence have been shown to be associated with the proliferation of dentate granule cells. In developing animals, the acute sequela of hilar damage and the chronic sequelae of spontaneous seizures and mossy fiber synaptic reorgani...

journal_title：Epilepsia

authors： Sankar R,Shin D,Liu H,Katsumori H,Wasterlain CG

更新日期：2000-01-01 00:00:00

abstract：:Homocysteine thiolactone (HTL) elicits seizures in mice at a dose of 850 mg/kg (95-100% of animals) with an average latency time of 19.5 min. These seizures are reversed by both 5' N-ethylcarboximide adenosine (NECA) and flunitrazepam, with respective ED50 doses of 0.025 and 0.20 mg/kg. NECA was approximately four-fol...

journal_title：Epilepsia

authors： Marangos PJ,Loftus T,Wiesner J,Lowe T,Rossi E,Browne CE,Gruber HE

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To determine the incidence, duration, risk factors for, and clinical correlates of postictal generalized electroencephalography (EEG) suppression (PGES), and to further delineate the significance of PGES in the pathogenesis of sudden unexpected death in epilepsy (SUDEP). METHODS:We retrospectively reviewed the...

journal_title：Epilepsia

authors： Tao JX,Yung I,Lee A,Rose S,Jacobsen J,Ebersole JS

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:In 1992, the International Lamotrigine Pregnancy Registry was initiated to enroll prospectively and to monitor pregnancies exposed to lamotrigine (LTG) for the occurrence of major birth defects. This study presents results as of September 2001 on 168 outcomes exposed to LTG monotherapy and 166 outcomes after pr...

journal_title：Epilepsia

authors： Tennis P,Eldridge RR,International Lamotrigine Pregnancy Registry Scientific Advisory Committee.

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:Hyperventilation is an activation method that provokes physiological slowing of brain rhythms, interictal discharges, and seizures, especially in generalized idiopathic epilepsies. In this study we assessed its effectiveness in inducing focal seizures during video-EEG monitoring. METHODS:We analyzed the effect...

journal_title：Epilepsia

authors： Guaranha MS,Garzon E,Buchpiguel CA,Tazima S,Yacubian EM,Sakamoto AC

更新日期：2005-01-01 00:00:00

abstract：:The diagnostic goals in nonsurgical (conservative) epileptology differ from presurgical diagnostic aims. The resulting development of diagnostic methods in a tertiary-level epilepsy center is shown and the major technical and organizational consequences of this difference for diagnostic long-term monitoring (LTM) as o...

journal_title：Epilepsia

authors： Ried S,Hilfiker P,Mothersill IW,Krämer G

更新日期：2000-01-01 00:00:00

abstract：:Clinical trials of antiepileptic drugs (AEDs) are usually performed only in major teaching centers, thus ignoring the very real contribution available from private practice. The relation between the consultant and the referring family physician is often much closer in private practice, allowing much earlier recruitmen...

journal_title：Epilepsia

authors： Beran RG,Tilley M

更新日期：1994-01-01 00:00:00

abstract：:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. The questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and the prevalenc...

journal_title：Epilepsia

authors： Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:In 2015, the International League Against Epilepsy (ILAE) proposed a new definition of status epilepticus (SE): 5 minutes of ongoing seizure activity to diagnose convulsive SE (CSE, ie, bilateral tonic-clonic SE) and 10 minutes for focal SE and absence SE, rather than the earlier criterion of 30 minutes. Base...

journal_title：Epilepsia

authors： Leitinger M,Trinka E,Giovannini G,Zimmermann G,Florea C,Rohracher A,Kalss G,Neuray C,Kreidenhuber R,Höfler J,Kuchukhidze G,Granbichler C,Dobesberger J,Novak HF,Pilz G,Meletti S,Siebert U

更新日期：2019-01-01 00:00:00

abstract：:Epilepsy syndromes occupy an important position in the current nosology of the epilepsies, describing and classifying seizure disorders with shared clinical and EEG features. Increasingly, this schema is being refined as new information becomes available and our understanding of etiology and presentation of each syndr...

journal_title：Epilepsia

authors： Duchowny M,Harvey AS

更新日期：1996-01-01 00:00:00

abstract：:Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies ha...

journal_title：Epilepsia

authors： Nicita F,Ruggieri M,Polizzi A,Mauceri L,Salpietro V,Briuglia S,Papetti L,Ursitti F,Grosso S,Tarani L,Segni M,Savasta S,Parisi P,Verrotti A,Spalice A

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Patients with Alzheimer's disease (AD) have an increased risk of developing seizures or epilepsy. Little is known about the role of risk factors and about the risk of developing seizures/epilepsy in patients with vascular dementia (VD). The aim of this study was to assess incidence rates (IRs) of seizures/epile...

journal_title：Epilepsia

authors： Imfeld P,Bodmer M,Schuerch M,Jick SS,Meier CR

更新日期：2013-04-01 00:00:00

abstract：:Twenty-seven epileptic patients, most from low socioeconomic groups and aged 15-54 years, were studied for effects of prolonged anticonvulsant medication. They had received the usual doses of phenobarbitone and diphenylhydantoin (PHT) regularly for 3-32 years, with control of seizures, and had not taken any B-vitamins...

journal_title：Epilepsia

authors： Dastur DK,Dave UP

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:This study evaluated topiramate (TPM) antagonism of glutamate receptors activated by kainate. METHODS:The ability of TPM (3-30 microM) to attenuate kainate (300 microM)-activated cobalt (Co2+) flux through nonselective cation channels permeable to Co2+, Mn2+, and Ca2+ into cultured cerebellar granule neurons [...

journal_title：Epilepsia

authors： Skradski S,White HS

更新日期：2000-01-01 00:00:00

abstract：:With the launching worldwide of a range of new antiepileptic drugs (AEDs), the prescriber has a much wider choice than ever before. Comparative studies between new and established AEDs are few, and those between new AEDs are rarely performed. This report considers the strengths and weaknesses of nine new and establish...

journal_title：Epilepsia

authors： Brodie MJ

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:We wished to determine the effects of seizure type, age at onset, and family history of epilepsy on risk of spontaneous abortion in the pregnancies of adults with idiopathic/cryptogenic epilepsy. METHODS:We examined pregnancy outcomes in 812 adults with idiopathic/cryptogenic epilepsy who had ever had or fathe...

journal_title：Epilepsia

authors： Schupf N,Ottman R

更新日期：1997-07-01 00:00:00

abstract：:Accurate identification of cortical malformations in children with epilepsy can be crucial for successful clinical management. Although standard head-coil magnetic resonance imaging (MRI) at 1.5 tesla (T) can be used to view the macrostructure of the brain, phased array technology at both 1.5 and 3T significantly impr...

journal_title：Epilepsia

authors： Grant PE

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Lesion-negative refractory partial epilepsy is a major challenge in the assessment of patients for potential surgery. Finding a potential epileptogenic lesion simplifies assessment and is associated with good outcome. Here we describe imaging features of subtle parahippocampal dysplasia in five cases that were ...

journal_title：Epilepsia

authors： Pillay N,Fabinyi GC,Myles TS,Fitt GJ,Berkovic SF,Jackson GD

更新日期：2009-12-01 00:00:00

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00