Topiramate blocks kainate-evoked cobalt influx into cultured neurons.

abstract：:Tiagabine (TGB) is a recently approved antiepileptic drug (AED) that inhibits y-aminobutyric acid (GABA) reuptake into neurons and glia, a mechanism of action that is specific and unique among the AEDs. TGB is potent and has linear and predictable pharmacokinetics. It has no clinically relevant effects on hepatic meta...

journal_title：Epilepsia

authors： Schachter SC

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:The occurrence of psychiatric symptoms after temporal lobectomy is well documented. The aim of the present study was to identify preoperative factors that predict postoperative psychiatric outcome. METHODS:We studied the case notes of 121 patients (from an initial sample of 167) who underwent temporal lobectom...

journal_title：Epilepsia

authors： Anhoury S,Brown RJ,Krishnamoorthy ES,Trimble MR

更新日期：2000-12-01 00:00:00

abstract：:Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...

journal_title：Epilepsia

authors： Zhang CL,Gloveli T,Heinemann U

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric acid (GABA) metabolism in the glutamate/glutamine cycle (GGC). Inhibition of GS results in changes of neurotransmitter release and recycling. However, little is known about the influence of GGC on neurotransmitter...

journal_title：Epilepsia

authors： Cremer CM,Bidmon HJ,Görg B,Palomero-Gallagher N,Escobar JL,Speckmann EJ,Zilles K

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The aim of this prospective incident community-based study was to assess the influence of pre- and perinatal risk factors in children in whom an unprovoked afebrile epileptic seizure later developed. METHODS:From November 1, 1985, until June 30, 1987, 75 children aged 0-15 years with a first unprovoked afebril...

journal_title：Epilepsia

authors： Sidenvall R,Heijbel J,Blomquist HK,Nyström L,Forsgren L

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:A large-scale, double-blind trial (SP0993; NCT01243177) demonstrated that lacosamide was noninferior to controlled-release carbamazepine (carbamazepine-CR) in terms of efficacy, and well tolerated as first-line monotherapy in patients (≥16 years of age) with newly diagnosed epilepsy. We report primary safety ...

journal_title：Epilepsia

authors： Ben-Menachem E,Grebe HP,Terada K,Jensen L,Li T,De Backer M,Steiniger-Brach B,Gasalla T,Brock M,Biton V

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Under an expanded access investigational new drug (IND) trial, cannabidiol (CBD) is being studied as a possible adjuvant treatment of refractory epilepsy in children. Of the 25 subjects in the trial, 13 were being treated with clobazam (CLB). Because CLB and CBD are both metabolized in the cytochrome P450 (CY...

journal_title：Epilepsia

authors： Geffrey AL,Pollack SF,Bruno PL,Thiele EA

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:A pilot study of the safety, tolerability, dose range and potential efficacy of ganaxolone for the treatment of refractory epilepsy in pediatric and adolescent subjects. METHODS:We report the results of a nonrandomized, nonblinded, open-label, dose-escalation trial of ganaxolone in pediatric subjects (5-15 yea...

journal_title：Epilepsia

authors： Pieribone VA,Tsai J,Soufflet C,Rey E,Shaw K,Giller E,Dulac O

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...

journal_title：Epilepsia

authors： Johannesen KM,Nikanorova N,Marjanovic D,Pavbro A,Larsen LHG,Rubboli G,Møller RS

更新日期：2020-06-01 00:00:00

abstract：:This paper addresses methodologic issues in studies of mortality, and the impact of these issues in studies of mortality in epilepsy. One important issue is to identify the question: Is it whether epilepsy increases the risk of dying? Or is it whether the underlying condition that led to epilepsy, itself associated wi...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC

更新日期：2005-01-01 00:00:00

abstract：:Folic acid deficient diet reduces the duration and severity of intravenous megimide seizures in the rat after 6 months of diet. Plasma and serum folate levels are strongly reduced after that period. The difference between Lactobacillus casei and Streptococcus faecalis activity in brain show a slight, but not significa...

journal_title：Epilepsia

authors： Hommes OR,ten Berge EJ,Jansen MJ,Kok JC

更新日期：1977-12-01 00:00:00

abstract：PURPOSE:To describe the semiologic features of aggressive behaviors observed in human epileptic seizures with particular reference to the act of biting a conspecific. METHODS:We analyzed the biting behavior (BB) and other aggressive gestures occurring in a group of 11 patients retrospectively selected from >1,000 pati...

journal_title：Epilepsia

authors： Tassinari CA,Tassi L,Calandra-Buonaura G,Stanzani-Maserati M,Fini N,Pizza F,Sartori I,Michelucci R,Lo Russo G,Meletti S

更新日期：2005-05-01 00:00:00

abstract：:A variety of surgical strategies are available to deal with intractable epilepsy. These are resective operations, consisting of the removal of a focus or a discrete lesion, gross removal of malfunctioning brain, and functional operations consisting of division of the pathways of propagation or of an epileptic neuronal...

journal_title：Epilepsia

authors： Polkey CE,Binnie CD

更新日期：1995-01-01 00:00:00

abstract：:This study sought to determine the frequency and clinical significance of nonhabitual seizures in 101 consecutive patients undergoing presurgical intracranial electroencephalography intracranial (icEEG) recording. We compared clinical data, recording details, and postsurgical outcome in patients with nonhabitual seizu...

journal_title：Epilepsia

authors： Kovac S,Rodionov R,Chinnasami S,Wehner T,Scott CA,McEvoy AW,Miserocchi A,Diehl B

更新日期：2014-01-01 00:00:00

abstract：:Early in these proceedings, the origin of the three terms in the title, "idiopathic generalized epilepsy," is discussed with respect to their significance over time, and typical misunderstandings. In the mid-20th century, a rather chaotic use of a multitude of often loosely defined terms had developed, which increasin...

journal_title：Epilepsia

authors： Wolf P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Assumptions regarding the benefits of seizure control after pediatric epilepsy surgery for cognitive, psychosocial, and family function were explored in a prospective study of 51 children with intractable epilepsy. METHODS:Thirty children who underwent surgery were studied before and 1 year after surgery, and ...

journal_title：Epilepsia

authors： Smith ML,Elliott IM,Lach L

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS:Long-Evans hooded rats were treated...

journal_title：Epilepsia

authors： Cortez MA,Cunnane SC,Snead OC 3rd

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Zinc is released in synaptic vesicles with glutamate, and modulates glutamatergic neurotransmission. In brain, the highest amount of zinc, detected by Timm staining, is in the mossy fiber (MF) system in the hippocampus. In the intrahippocampal kainate (KA) mouse model of mesial temporal lobe epilepsy, which is ...

journal_title：Epilepsia

authors： Mitsuya K,Nitta N,Suzuki F

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To estimate magnetoencephalography (MEG) correlates of different types of aura in temporal lobe epilepsy (TLE). METHODS:MEG study was performed on 57 patients (26 male and 31 female) with TLE, whose ages ranged from 14-46 years (mean 27 years). Interictal magnetoencephalograms showing discharges were analyzed,...

journal_title：Epilepsia

authors： Fukao K,Inoue Y,Yagi K

更新日期：2010-09-01 00:00:00

abstract：:Leucoencephalopathy with vanishing white matter (VWM) is caused by mutations in the genes encoding for one of the five subunits that constitute the eukaryotic initiation factor 2B (eIF2B), and is characterized by a highly suggestive MRI pattern indicating vanishing of the cerebral white matter. Seizures are well known...

journal_title：Epilepsia

authors： Jansen AC,Andermann E,Niel F,Creveaux I,Boespflug-Tanguy O,Andermann F

更新日期：2008-05-01 00:00:00

abstract：:Epilepsy is a disease of recurrent seizures that can be associated with a wide variety of acquired and developmental brain lesions. Current medications for patients with epilepsy can suppress seizures; they do not cure or modify the underlying disease process. On the other hand, surgical removal of focal brain regions...

journal_title：Epilepsia

authors： Mittal S,Shah AK,Barkmeier DT,Loeb JA

更新日期：2013-12-01 00:00:00

abstract：:The acute effects of valproate (200 and 400 mg/kg), ethosuximide (200 and 400 mg/kg), phenytoin (25 and 50 mg/kg), and pentobarbital (30 and 60 mg/kg) on cerebral energy metabolism of rats were studied by measuring the cerebral content of energy metabolites and by evaluating the rate of metabolite utilization followin...

journal_title：Epilepsia

authors： Gueldry S,Rochette L,Bralet J

更新日期：1987-03-01 00:00:00

abstract：:Twenty-three infants and children underwent cortical resection (n = 15) or hemispherectomy (n = 8) for intractable infantile spasms. Infantile spasms were present at the time of surgery in 17 of the 23 patients; in six, spasms had evolved to other seizure types during surgical evaluation. Children with a remote histor...

journal_title：Epilepsia

authors： Chugani HT,Shewmon DA,Shields WD,Sankar R,Comair Y,Vinters HV,Peacock WJ

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the abil...

journal_title：Epilepsia

authors： Martin P,Winston GP,Bartlett P,de Tisi J,Duncan JS,Focke NK

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:The role of alpha 1b-adrenergic receptor (alpha 1b-AR) in relation with neuronal degeneration, drug addiction, and seizure susceptibility has recently emerged. In particular, mice that overexpress alpha 1b-AR undergo spontaneous epileptic seizures and progressive neuronal loss in a variety of brain areas. There...

journal_title：Epilepsia

authors： Pizzanelli C,Lazzeri G,Fulceri F,Giorgi FS,Pasquali L,Cifelli G,Murri L,Fornai F

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The aim of this article is to review the literature on the effects of psychostimulants in epileptic subjects in order to reach a consensus statement regarding the use or abuse of these substances. METHODS:Psychostimulant substances have been considered the drugs that share the ability to produce excitation of ...

journal_title：Epilepsia

authors： Zagnoni PG,Albano C

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Previous validation studies assessing the use of administrative data to identify patients with epilepsy have used targeted sampling or have used a reference standard of patients in the neurologist, hospital, or emergency room setting. Therefore, the validity of using administrative data to identify patients w...

journal_title：Epilepsia

authors： Tu K,Wang M,Jaakkimainen RL,Butt D,Ivers NM,Young J,Green D,Jetté N

更新日期：2014-02-01 00:00:00

abstract：:In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

journal_title：Epilepsia

authors： McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

更新日期：2020-08-01 00:00:00

abstract：:Approximately three-quarters of epileptic patients seen in consultation by specialists can easily be assigned to one of the diagnostic categories of the International League against Epilepsy. When patient age is taken into account, such a distribution shows that partial epilepsy is more common than generalized epileps...

journal_title：Epilepsia

authors： Gastaut H,Gastaut JL,Gonçalves e Silva GE,Fernandez Sanchez GR

更新日期：1975-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a potentially preventable cause of epilepsy. Increasing incidence among army personnel and the high incidence among children and young people raise concern. This article presents a review of selected studies dealing with the risks of TBI and the risk of posttraumatic epilepsy in humans....

journal_title：Epilepsia

authors： Christensen J

更新日期：2012-09-01 00:00:00