Leucoencephalopathy with vanishing white matter may cause progressive myoclonus epilepsy.

abstract：:Astrocyte and microglial activation occurs following seizures and plays a role in epileptogenesis. However, the precise temporal and spatial response to seizures has not been fully examined. The pilocarpine model of temporal lobe epilepsy was selected to examine glial changes following seizures because morphological c...

journal_title：Epilepsia

authors： Shapiro LA,Wang L,Ribak CE

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Our aim was to develop a screening test to predict Dravet syndrome before the first birthday based on the clinical characteristics of infants and the SCN1A mutation analysis. METHODS:Ninety-six patients who experienced febrile seizures before the age of one were enrolled. The patients were divided into two gro...

journal_title：Epilepsia

authors： Hattori J,Ouchida M,Ono J,Miyake S,Maniwa S,Mimaki N,Ohtsuka Y,Ohmori I

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...

journal_title：Epilepsia

authors： Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

更新日期：2009-05-01 00:00:00

abstract：:The pharmacokinetics of antiepileptic drugs have been investigated extensively during the last two decades. It has become evident that the therapeutic management of epileptic patients would be significantly improved with the elimination of the drawbacks associated with existing antiepileptic drugs. Based on the inform...

journal_title：Epilepsia

authors： Levy RH,Kerr BM

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:To identify risk and risk factors for developing a subsequent febrile seizure (FS) in children with a first febrile status epilepticus (FSE) compared to a first simple febrile seizure (SFS). To identify home use of rescue medications for subsequent FS. METHODS:Cases included a first FS that was FSE drawn fr...

journal_title：Epilepsia

authors： Hesdorffer DC,Shinnar S,Lax DN,Pellock JM,Nordli DR Jr,Seinfeld S,Gallentine W,Frank LM,Lewis DV,Shinnar RC,Bello JA,Chan S,Epstein LG,Moshé SL,Liu B,Sun S,FEBSTAT study team.

更新日期：2016-07-01 00:00:00

abstract：:Children with epilepsy often grow into adults with significant social problems including decreased employment, marriage, social relationships, and independent living arrangements. These problems are noted in population-based longitudinal and cross-sectional studies from many countries. Learning disorder and mental han...

journal_title：Epilepsia

authors： Camfield CS,Camfield PR

更新日期：2007-01-01 00:00:00

abstract：:The literature dealing with the convulsant effects of the antidepressant drugs of the non-monoamine oxidase inhibitor variety is reviews. It is concluded that most of these drugs do lower the seizure threshold and may precipitate seizures even at normal therapeutic doses. The pathophysiology of antidepressant-induced ...

journal_title：Epilepsia

authors： Trimble M

更新日期：1978-06-01 00:00:00

abstract：:The long-standing practice of polypharmacy in treating epilepsy is giving way to use of monotherapy. Monotherapy can improve seizure control as well as reduce the risk of serious idiosyncratic reactions, dose-related side effects, and complex drug interactions. Monotherapy also offers improved compliance and cost-effe...

journal_title：Epilepsia

authors： Wilder BJ

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To analyze the relationship between ictal electroencephalography (EEG) and ictal single-photon emission computed tomography (SPECT) and to evaluate the diagnostic usefulness of ictal SPECT as an independent presurgical evaluation technique. METHODS:Sixty-eight patients with temporal lobe epilepsy who underwent...

journal_title：Epilepsia

authors： Lee SK,Lee SH,Kim SK,Lee DS,Kim H

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:In patients with temporal lobe epilepsy (TLE) with a nonlesional and nonepileptogenic hippocampus (HC), in order to preserve functionally intact brain tissue, the HC is not resected. However, some patients experience postoperative memory decline, possibly due to disruption of the extrahippocampal memory netwo...

journal_title：Epilepsia

authors： Wagner K,Gau K,Metternich B,Geiger MJ,Wendling AS,Kadish NE,Reuner G,Mayer H,Mader I,Beck J,Zentner J,Urbach H,Schulze-Bonhage A,Kaller CP,Foit NA

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To evaluate prospectively patient's aims for epilepsy surgery as previously outlined theoretically by Taylor et al. (Epilepsia 1997;3:625-30). METHODS:Ninety-three consecutive patients were interviewed by a psychiatrist as part of their evaluation for epilepsy surgery. Open-ended questions about the patient we...

journal_title：Epilepsia

authors： Taylor DC,McMacKin D,Staunton H,Delanty N,Phillips J

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:  Vagus nerve stimulation (VNS) provides partial relief of medically refractory partial seizures in a subset of patients. The optimal pattern of stimulation and the mechanism of the antiseizure effects are uncertain. Establishing the efficacy of VNS in an animal model of epilepsy would provide an experimental p...

journal_title：Epilepsia

authors： Alexander GM,McNamara JO

更新日期：2012-11-01 00:00:00

abstract：:5-Hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by high-performance liquid chromatography (HPLC) in lumbar cerebrospinal fluid (CSF) obtained from febrile children subdivided according to the presence or absence of convulsions. Lumbar puncture was made either early (mean time 2 h) or late...

journal_title：Epilepsia

authors： Giroud M,Dumas R,Dauvergne M,D'Athis P,Rochette L,Beley A,Bralet J

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Standard mortality ratio for suicide in patients with epilepsy is three times higher than in the general population, and such a risk remains high even after adjusting for clinical and socioeconomic factors. It is thus important to have suitable screening instruments and to implement care pathways for suicide ...

journal_title：Epilepsia

authors： Mula M,McGonigal A,Micoulaud-Franchi JA,May TW,Labudda K,Brandt C

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. A substantial number of past studies examined factors that predict memory decline after surger...

journal_title：Epilepsia

authors： Lineweaver TT,Morris HH,Naugle RI,Najm IM,Diehl B,Bingaman W

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to clarify and compare the influence of surgical strategy on relief from seizures in patients with focal cortical dysplasia (FCD) and those with dysembryoplastic neuroepithelial tumor (DNT). METHODS:Six patients with FCD and five patients with DNT, all of whom underwent surgical r...

journal_title：Epilepsia

authors： Kameyama S,Fukuda M,Tomikawa M,Morota N,Oishi M,Wachi M,Kanazawa O,Sasagawa M,Kakita A,Takahashi H

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Previous studies have documented a synaptic translocation of calcineurin (CaN) and increased CaN activity following status epilepticus (SE); however, the cellular effect of these changes in CaN in the pathology of SE remains to be elucidated. This study examined a CaN-dependent modification of the dendritic cyt...

journal_title：Epilepsia

authors： Kurz JE,Moore BJ,Henderson SC,Campbell JN,Churn SB

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. Howev...

journal_title：Epilepsia

authors： Pennell PB,Burdette DE,Ross DA,Henry TR,Albin RL,Sackellares JC,Frey KA

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:We studied the effect of vagus nerve stimulation (VNS) on seizure reduction in patients with intractable epilepsy with bilateral independent temporal lobe foci. METHODS:Ten patients who met the criterion of the presence of two distinctive clinical and ictal EEG seizure patterns were identified and followed up ...

journal_title：Epilepsia

authors： Alsaadi TM,Laxer KD,Barbaro NM,Marks WJ Jr,Garcia PA

更新日期：2001-07-01 00:00:00

abstract：:Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. T...

journal_title：Epilepsia

authors： Morris GL 3rd,Mueller WM,Yetkin FZ,Haughton VM,Hammeke TA,Swanson S,Rao SM,Jesmanowicz A,Estkowski LD,Bandettini PA

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:Management of seizures in learning disabled people is challenging. This prospective study explored the efficacy and tolerability of adjunctive topiramate (TPM) in patients with learning disability and refractory epilepsy attending a single centre. METHODS:Sixty-four patients (36 men, 28 women, aged 16-65 years...

journal_title：Epilepsia

authors： Kelly K,Stephen LJ,Sills GJ,Brodie MJ

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:Genetic variants in STXBP1, which encodes the conserved exocytosis protein Munc18-1, are associated with a variety of infantile epilepsy syndromes. We aimed to develop an in vivo Caenorhabditis elegans model that could be used to test the pathogenicity of such variants in a cost-effective manner. METHODS:The...

journal_title：Epilepsia

authors： Zhu B,Mak JCH,Morris AP,Marson AG,Barclay JW,Sills GJ,Morgan A

更新日期：2020-04-01 00:00:00

abstract：:In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of...

journal_title：Epilepsia

authors： Yacubian EM,Rosemberg S,Marie SK,Valério RM,Jorge CL,Cukiert A

更新日期：1996-05-01 00:00:00

abstract：:Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting had been shown to be associated with improved outcomes, but the comparative efficacy and safety of an intramuscular (IM) route, which is faster and consistently achievable, was previously unknown. RA...

journal_title：Epilepsia

authors： Silbergleit R,Lowenstein D,Durkalski V,Conwit R,NETT Investigators.

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Previous studies have shown that the immunosuppressant cyclosporin A (CsA), a specific blocker of the mitochondrial permeability transition (MPT) pore, can dramatically ameliorate the selective neuronal necrosis resulting from ischemia-reperfusion, traumatic brain injury, and N-methyl-d-aspartate (NMDA)-evoked ...

journal_title：Epilepsia

authors： Santos JB,Schauwecker PE

更新日期：2003-08-01 00:00:00

abstract：:The in vivo incorporation of [14C] from [U-14C]-glucose into rat brain proteins from different cortical areas was examined in three different experimental focal epilepsies: cobalt, freeze-lesions, and tityustoxin. When [U-14C]-glucose was injected intraperitoneally into awake and unrestrained animals with marked signs...

journal_title：Epilepsia

authors： Coutinho-Netto J,Boyar MM,Abdul-Ghani AS,Bradford HF

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...

journal_title：Epilepsia

authors： Glauser TA,Miles MV,Tang P,Clark P,McGee K,Doose DR

更新日期：1999-06-01 00:00:00

abstract：:To try to identify the critical structures during epileptogenesis, we used the lithium-pilocarpine model that reproduces most clinical and neuropathological features of temporal lobe epilepsy (TLE). We used imaging techniques as well as a disease modifying approach and pharmacological strategy. With [14C]-2-deoxygluco...

journal_title：Epilepsia

authors： André V,Dubé C,François J,Leroy C,Rigoulot MA,Roch C,Namer IJ,Nehlig A

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Medically refractory epilepsy caused by cortical tubers resulting from tuberous sclerosis complex (TSC) often requires surgical intervention. The locations of cortical tubers generally are determined by preoperative magnetic resonance imaging (MRI). In this pilot study, we explored the feasibility of using the ...

journal_title：Epilepsia

authors： Oh S,Stewart T,Miller I,Bhatia S,Ragheb J,Duchowny M,Jayakar P,Lin WC

更新日期：2011-09-01 00:00:00

abstract：:The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...

journal_title：Epilepsia

authors： Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

更新日期：2009-07-01 00:00:00