Surgery for intractable infantile spasms: neuroimaging perspectives.

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：:The course and outcome of epilepsy following central nervous system (CNS) infections has been poorly characterized. Likewise, the impact of antimicrobial treatment as well as other preventative and therapeutic interventions on the development of epilepsy following neurological infectious disorders has been insufficien...

journal_title：Epilepsia

authors： Singh G,Prabhakar S

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Identification of patients at risk of developing epilepsy before the first spontaneous seizure may promote the development of preventive treatment providing opportunity to stop or slow down the disease. METHODS:As development of novel radiotracers and on-site setup of existing radiotracers is highly time-con...

journal_title：Epilepsia

authors： Bascuñana P,Gendron T,Sander K,Jahreis I,Polyak A,Ross TL,Bankstahl M,Arstad E,Bankstahl JP

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Epilepsy is the most common serious neurologic disease, and current treatments are ineffective for

journal_title：Epilepsia

authors： Nilsen KE,Kelso AR,Cock HR

更新日期：2006-07-01 00:00:00

abstract：:Androgen deficiency is unusually common among men with epilepsy. It may contribute to reproductive and sexual dysfunction and possibly exacerbate seizure frequency. The most important androgen is testosterone. it exists in the serum in a free form or bound to albumin or sex hormone-binding globulin (SHBG). Free testos...

journal_title：Epilepsia

authors： Herzog AG

更新日期：1991-01-01 00:00:00

abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

journal_title：Epilepsia

authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the utility of baseline neuropsychological measures and scores from the intracarotid amobarbital procedure (IAP) in the prediction of postoperative memory decline in temporal lobe epilepsy surgery patients. METHODS:Logistic regression analyses were used to determine the rel...

journal_title：Epilepsia

authors： Baxendale S,Thompson P,Harkness W,Duncan J

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate health care expenditures among elderly patients with epilepsy in the United States. METHODS:We performed an analysis of weighted 37 738 607 US participants aged 65 years to estimate health care expenditures in the elderly with and without epilepsy using the Medical E...

journal_title：Epilepsia

authors： Lekoubou A,Bishu KG,Ovbiagele B

更新日期：2018-07-01 00:00:00

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：:Studies from several countries have reported that fewer people with epilepsy marry, but the reasons for this are not clear. In the present investigation, 178 adults with epilepsy were divided into married, separated/divorced, and never married groups. The never married group was subdivided into persons living in depen...

journal_title：Epilepsia

authors： Batzel LW,Dodrill CB

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:Although levetiracetam undergoes minimum metabolism, B-esterases have been identified in whole blood that are capable of metabolising levetiracetam. The present study was designed to ascertain any variability in levetiracetam blood concentrations that could be attributed to in situ metabolism and which could im...

journal_title：Epilepsia

authors： Patsalos PN,Ghattaura S,Ratnaraj N,Sander JW

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To induce status epilepticus (SE) followed by the subsequent onset of spontaneous recurrent seizures, thus characterizing a new model of temporal lobe epilepsy in a nonhuman primate. METHODS:Male and female marmosets (Callithrix jacchus) (n = 18), ages between 2 and 8 years, were injected with domoic acid (0.5...

journal_title：Epilepsia

authors： Perez-Mendes P,Cinini SM,Medeiros MA,Tufik S,Mello LE

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children. Clinical symptoms of phenobarbital hypersensitivity vary from maculopapular rashes (MPs) to severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS),...

journal_title：Epilepsia

authors： Manuyakorn W,Mahasirimongkol S,Likkasittipan P,Kamchaisatian W,Wattanapokayakit S,Inunchot W,Visudtibhan A,Wichukchinda N,Benjaponpitak S

更新日期：2016-10-01 00:00:00

abstract：:The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

journal_title：Epilepsia

authors： Schramm J

更新日期：2008-08-01 00:00:00

abstract：:The ketogenic diet (KD) is a medical nutrition therapy (MNT) for the treatment of epilepsy. As such, it can affect the outcome of an individual's health and chronic medical condition. The components of MNT which have been established by the American Dietetic Association as core guidelines for nutrition care include a ...

journal_title：Epilepsia

authors： Zupec-Kania B,Zupanc ML

更新日期：2008-11-01 00:00:00

abstract：:This study aimed to determine clinical features of adult patients with gelastic seizures recorded on video -electroencephalography (EEG) over a 5-year period. We screened video-EEG telemetry reports for the occurrence of the term "gelastic" seizures, and assessed the semiology, EEG features, and duration of those seiz...

journal_title：Epilepsia

authors： Kovac S,Diehl B,Wehner T,Fois C,Toms N,Walker MC,Duncan JS

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To evaluate how diagnostic criteria influence remission rates for patients with childhood absence epilepsy (CAE) and to assess clinical and EEG parameters as predictors of outcome. METHODS:One hundred nineteen patients were diagnosed with CAE, according to International League Against Epilepsy (ILAE) classific...

journal_title：Epilepsia

authors： Grosso S,Galimberti D,Vezzosi P,Farnetani M,Di Bartolo RM,Bazzotti S,Morgese G,Balestri P

更新日期：2005-11-01 00:00:00

abstract：:Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X-linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Although medically refractory epilepsy often brings attention to...

journal_title：Epilepsia

authors： Montier L,Haneef Z,Gavvala J,Yoshor D,North R,Verla T,Van Ness PC,Drabek J,Goldman AM

更新日期：2019-10-01 00:00:00

abstract：:Cytoarchitectural alterations during central nervous system (CNS) development are believed to underlie aberrations in brain morphology that lead to epilepsy. We have recently reported marked reductions in hippocampal and white matter volumes along with relative ventriculomegaly in a rat strain bred to be seizure-prone...

journal_title：Epilepsia

authors： Gilby KL,Crino P,McIntyre DC

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). METHODS:Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing...

journal_title：Epilepsia

authors： Kälviäinen R,Genton P,Andermann E,Andermann F,Magaudda A,Frucht SJ,Schlit AF,Gerard D,de la Loge C,von Rosenstiel P

更新日期：2016-02-01 00:00:00

abstract：:Nuclear magnetic resonance is a noninvasive technique of imaging the brain using signals produced by magnetic fields and radiowaves. Sixteen patients with refractory temporal lobe epilepsy (TLE) had magnetic resonance imaging (MRI) during investigation for possible surgical management. These images plus those of 10 no...

journal_title：Epilepsia

authors： McLachlan RS,Nicholson RL,Black S,Carr T,Blume WT

更新日期：1985-11-01 00:00:00

abstract：PURPOSE:To clarify the differences between postictal mania (PIM) and postictal psychosis (PIP). METHODS:Five patients with PIM were compared to 17 patients with PIP, with respect to clinical, epileptological, electrophysiological, and neuroimaging features. PIM was distinguished from PIP by the symptoms observed in th...

journal_title：Epilepsia

authors： Nishida T,Kudo T,Inoue Y,Nakamura F,Yoshimura M,Matsuda K,Yagi K,Fujiwara T

更新日期：2006-12-01 00:00:00

abstract：:There is no doubt that structural morphological brain lesions and malformations in epilepsy represent major etiological factors for the cognitive impairments seen in this disease. The role of epileptic activity and seizures for cognition and cognitive development, however, is less easily determined. Epileptic dysfunct...

journal_title：Epilepsia

authors： Helmstaedter C

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Posttraumatic epilepsy (PTE) accounts for 20% of acquired epilepsies. Experimental models are important for studying epileptogenesis. We previously reported that repetitive high-frequency oscillations with spikes (rHFOSs) occur early after lateral fluid percussion injury (FPI) and may be a biomarker for PTE. ...

journal_title：Epilepsia

authors： Reid AY,Bragin A,Giza CC,Staba RJ,Engel J Jr

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuro...

journal_title：Epilepsia

authors： Zhou FW,Rani A,Martinez-Diaz H,Foster TC,Roper SN

更新日期：2011-12-01 00:00:00

abstract：:Little is known about the effects of carbamazepine (CBZ) on sleep despite the relationship between sleep and epilepsy and the common clinical use of CBZ. As part of a larger study on sleep and interictal activity in kindled cats, we performed sleep recordings in 11 normal cats before and after acute administration of ...

journal_title：Epilepsia

authors： Gigli GL,Gotman J,Thomas ST

更新日期：1988-11-01 00:00:00

abstract：:Despite the introduction of newer antiepileptic drugs (AEDs), nonresponsiveness to AEDs remains a common problem in epilepsy clinics. There may be important genetic determinants for responsiveness, and this discussion focused on some potential areas: drug transporters; drug-metabolizing enzymes, and ion channels. We r...

journal_title：Epilepsia

authors： Ramachandran V,Shorvon SD

更新日期：2003-01-01 00:00:00

abstract：:In a prospective study of 117 adult ambulatory patients, 110 of whom were epileptics treated only with oral diphenylhydantoin (DPH), plasma levels of this drug were determined by gas-liquid chromatography. The average follow-up time was 6 months (range, 3 to 13 months); satisfactory control of seizures was obtained wi...

journal_title：Epilepsia

authors： Galdames DG,Saavedra IN,Ortiz MA,Aguilera LI,Valenzuela AL,Concha GL,Droguett PA,Morales ER

更新日期：1980-10-01 00:00:00

abstract：PURPOSE:To study the course and outcome of childhood-onset epilepsy during 15-year follow-up (FU). METHODS:We extended FU in 413 of 494 children with new-onset epilepsy recruited in a previously described prospective hospital-based study by questionnaire. RESULTS:Mean FU was 14.8 years (range 11.6-17.5 years). Five-y...

journal_title：Epilepsia

authors： Geerts A,Arts WF,Stroink H,Peeters E,Brouwer O,Peters B,Laan L,van Donselaar C

更新日期：2010-07-01 00:00:00