Abstract:
:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulation in models of epileptic seizures. We show that the effects of stimulation during epileptic seizures can differ from those observed under normal conditions. Several studies suggest a potentially greater beneficial therapeutic effect of strong depolarizing and overactivating stimulations than hyperpolarizing ones in the treatment of seizures. The potential relevance of these results to other therapeutic stimulation protocols is discussed.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Jiruska P,Powell AD,Deans JK,Jefferys JGdoi
10.1111/j.1528-1167.2010.02619.xsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
93-7eissn
0013-9580issn
1528-1167pii
EPI2619journal_volume
51 Suppl 3pub_type
杂志文章,评审相关文献
EPILEPSIA文献大全abstract:PURPOSE:To characterize the epileptogenic zone in neocortical epilepsy (NE) by using magnetoencephalography (MEG). METHODS:We defined and compared locations of single and multiple clusters of equivalent current dipoles (ECDs) for interictal spikes with MRI findings, ictal-onset zones (IOZs) from subdural electroenceph...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00428.x
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:Epileptic spasms are seizures that occur predominantly in children and are characterized by clusters of brief axial movements. Epileptic spasms may occur in the context of a variety of syndromes. Previous research has found that epileptic spasms occur in a sleep/wake and diurnal rhythm. The purpose of this stud...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2012.03499.x
更新日期:2012-07-01 00:00:00
abstract::Idiopathic epilepsies comprise a wide variety of partial and generalized syndromes that have in common a known or presumed genetic etiology and the lack of overt abnormalities other than the epilepsy itself. Most of these epilepsies have a benign natural history and/or show a favorable response to antiepileptic drug (...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1046/j.1528-1157.2001.042suppl.3031.x
更新日期:2001-01-01 00:00:00
abstract::Visual behavior is frequently impaired at onset of West syndrome (WS). We studied the neuropsychological outcome of eight children who had cryptogenic WS and moderate to severe visual impairment at the onset of epilepsy. At the last examination, a regional cerebral blood flow study using SPECT (single photon emission ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb00448.x
更新日期:1993-07-01 00:00:00
abstract::This study aimed to determine clinical features of adult patients with gelastic seizures recorded on video -electroencephalography (EEG) over a 5-year period. We screened video-EEG telemetry reports for the occurrence of the term "gelastic" seizures, and assessed the semiology, EEG features, and duration of those seiz...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12868
更新日期:2015-01-01 00:00:00
abstract::A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory result...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1994.tb02927.x
更新日期:1994-01-01 00:00:00
abstract::In 2011, the American Academy of Neurology (AAN) established eight epilepsy quality measures (EQMs) for chronic epilepsy treatment to address deficits in quality of care. This study assesses the relationship between adherence to these EQMs and epilepsy-related adverse hospitalizations (ERAHs). A retrospective chart re...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.12965
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Surgical resection of seizure-producing brain tissue is a gold standard treatment for drug-resistant focal epilepsy. However, several patient-specific factors can preclude resective surgery, including a spatially extensive ("regional") seizure-onset zone (SOZ). For such patients, responsive neurostimulation (...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/epi.16409
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital, valproate, and ethosuximide, or vehicle. METHODS:In acute studies of anticonvulsant efficacy, the AEDs were administered via or...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01552.x
更新日期:2008-07-01 00:00:00
abstract::Children with malformations of cortical development represent a significant proportion of pediatric epilepsy surgery candidates. From a cohort of 40 children operated on between 1980 and 1992 with malformation of cortical development, 38 were alive and had data 10 years after surgery. Age at surgery ranged from 6 mont...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.52504.x
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. METHODS:Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01413.x
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:Felbamate (FBM) is a new antiepileptic drug (AED) that is often effective in seizure disorders refractory to other treatments; its use has been greatly restricted after cases of aplastic anemia were reported. To elucidate the putative association between FBM and aplastic anemia, we made a detailed evaluation of...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1157.1997.tb00062.x
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:Subtle microdysplastic features are found in some patients with hippocampal sclerosis (HS) and refractory temporal lobe epilepsy. The significance of these findings is unknown. We investigated their frequency, relation to the pattern of HS, and clinical associations. METHODS:One-hundred forty patients with his...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2004.57203.x
更新日期:2004-08-01 00:00:00
abstract::Genomic findings are emerging rapidly in 2 large, closely related epilepsy research consortia: the Epilepsy Phenome/Genome Project and Epi4K. Disclosure of individual results to participants in genomic research is increasingly viewed as an ethical obligation, but strategies for return of results were not included in t...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.14530
更新日期:2018-09-01 00:00:00
abstract::A 25-year-old man presented with seizures characterized by unconsciousness, automatic behavior, and myoclonic jerks lasting 0.5 to 8 sec. Videotape analysis of 300 simultaneously recorded electroencephalographic and clinical attacks revealed 8- to 9-Hz 150 to 200 muV sharp waves beginning in both medial temporal areas...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1975.tb06081.x
更新日期:1975-09-01 00:00:00
abstract::Autoantibodies to surface proteins that influence neuronal excitability are increasingly found in different forms of epilepsy or encephalitis in adults, and are also beginning to be identified in children. The conditions are often refractory to traditional antiepileptic drugs. Detection of these antibodies can help to...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2011.03224.x
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 +/- 1 days; the id...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2005.46904.x
更新日期:2005-03-01 00:00:00
abstract::Of the 605 patients seen since 1973, 336 patients have been treated with sodium valproate (VPA) alone or in combination with drugs other than carbamazepine (CBZ). Of these 336, 240 have been on monotherapy, of whom 200 are seizure-free. Follow up has been longer than 3 years in 78%. Complete control of seizures has be...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1982.tb05085.x
更新日期:1982-12-01 00:00:00
abstract:PURPOSE:To describe the behavioral and EEG topographic correlates of absences with 3-Hz generalized spike-waves and partitioned impairment of consciousness. METHODS:Two adult women had so-called "phantom" absences, characterized by brief and mild impairments of consciousness that were previously inconspicuous to both ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.2000.tb00229.x
更新日期:2000-06-01 00:00:00
abstract::The results of surgical treatment of intractable epilepsy seizures in a group of patients investigated with the intracarotid amobarbital-pentylenetetrazol EEG test were analyzed. This diagnostic test, originally designed to distinguish a mechanism of primary from that of secondary bilateral synchrony in the EEG was al...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1976.tb03377.x
更新日期:1976-03-01 00:00:00
abstract:PURPOSE:Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The purpose of the present study was to evaluate the efficacy of carisbamate on spontaneous motor seizures in rats with kainate-induced epilepsy. METHODS:Repeated, low-dose (5 mg/kg), intraperito...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01657.x
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Ablation surgery has become the first line of treatment for hypothalamic hamartomas (HHs). For effective treatment, optimum targeting of ablation is mandatory. The present study aimed to evaluate the correspondence between the electrophysiological features of HHs and morphological targeting by semimicrorecord...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16730
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Our objective was to identify whether the whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from alterations in patients without FBTCS. METHODS:We dichotomized a cohort of 83 drug-resistant patients with TLE in...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16819
更新日期:2021-01-21 00:00:00
abstract:PURPOSE:To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment. METHODS:Twelve patients with epilepsy stabilized on PHT monotherapy were enrolled in this st...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.41701.x
更新日期:2002-07-01 00:00:00
abstract::Clinically, and in experimental models, perinatal hypoxic encephalopathy is commonly associated with seizures. We previously described a rat model in which hypoxia induces seizures and permanently increases in seizure susceptibility in immature rats [postnatal day (P) 10-12] but not in older rats. In the present study...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1995.tb00954.x
更新日期:1995-10-01 00:00:00
abstract::We present a technique for automatic detection of epileptic spikes in electroencephalogram (EEG) recordings. We used a nonlinear modeling method that enables us to detect rapidly and accurately epileptic behavior in the EEG signal. Our approach is illustrated by an application to interictal activity from a patient wit...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.43.s.5.7.x
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03114.x
更新日期:2011-09-01 00:00:00
abstract::We studied 47 consecutive patients who underwent temporal resection for seizure control. Nineteen (40%) had febrile convulsions preceding onset of their habitual seizures. In 17 of 18 patients whose disease duration was known, the febrile convulsions were prolonged (mean 4 h). As compared with patients without precedi...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb02105.x
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:To address concerns about possible increases in rates of sudden unexplained death (SUD) after use of new anticonvulsants, more information on the rate of SUD among subjects with refractory epilepsy is needed to provide a comparison. METHODS:We conducted a study to estimate the incidence of SUD among subjects y...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1996.tb00529.x
更新日期:1996-10-01 00:00:00
abstract:PURPOSE:Few data describe the sensitivity of a "Seizure Activity Detection Computer" (SzAC) in childhood video/EEG (VEEG) monitoring, especially for very young children. We examined the accuracy of SzAC in childhood VEEG monitoring in different pediatric age groups. METHODS:We visually analyzed VEEG monitoring samples...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1997.tb01216.x
更新日期:1997-11-01 00:00:00