Plasma levels of diphenylhydantoin and the control of adult epileptic seizures: a Chilean experience.

abstract：:Polypharmacy is a widely employed treatment strategy in epilepsy, particularly for individuals with poorly controlled seizures. Drug combinations should be carefully considered to minimize the potential for unfavorable interactions. Older-generation antiepileptic drugs (AEDs) are well known for their pharmacokinetic i...

journal_title：Epilepsia

authors： Sills G,Brodie M

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the effect of a new antiseizure drug, retigabine (D-23129; N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid ethyl ester) on low-Mg2+-induced epileptiform discharges in rat in vitro. METHODS:Three types of epileptiform discharges (recurrent short discharges in t...

journal_title：Epilepsia

authors： Armand V,Rundfeldt C,Heinemann U

更新日期：2000-01-01 00:00:00

abstract：:In 1990, the NIH Consensus Conference Panel on epilepsy surgery called for the development and use of reliable and valid health-related quality-of-life (HRQOL) measures in epilepsy surgery studies. A HRQOL measure for epilepsy surgery patients has been developed and evaluated. The procedure, which could also be used t...

journal_title：Epilepsia

authors： Vickrey BG

更新日期：1993-01-01 00:00:00

abstract：:The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. ...

journal_title：Epilepsia

authors： Irizarry R,Sukato D,Kollmar R,Schild S,Silverman J,Sundaram K,Stephenson S,Stewart M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). This is a validated model for absence epilepsy, characterized by frequent spontaneous absences concomitant with spike and wave discharges (SWD) on the E...

journal_title：Epilepsia

authors： Dedeurwaerdere S,Vonck K,Van Hese P,Wadman W,Boon P

更新日期：2005-01-01 00:00:00

abstract：:Benzodiazepines (BDZ) interact with components of neuronal membranes to modify excitability in three different ways. Action at a high affinity central receptor (dissociation constant, KD, of 3 nM) linked to the GABAA recognition site enhances the inhibitory action of GABA by increasing the number of openings of Cl- ch...

journal_title：Epilepsia

authors： Meldrum BS,Chapman AG

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...

journal_title：Epilepsia

authors： Ahmadiani A,Mandgary A,Sayyah M

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET. METH...

journal_title：Epilepsia

authors： Kilaru S,Bergqvist AGC

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:Prior studies have given conflicting data concerning the association of benign rolandic epilepsy of childhood (BREC) and migraine but were limited by lack of sensitive, diagnostic criteria for childhood migraine. By using revised International Headache Society (IHS-R) criteria, we compared the prevalence of mig...

journal_title：Epilepsia

authors： Wirrell EC,Hamiwka LD

更新日期：2006-10-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) can be used for noninvasive measurement of more than two dozen small metabolites in the brains of living animals and humans. In the first decade of its use for study of seizure phenomena in animals, MRS successfully detected in vivo seizure-induced cerebral acidosis and reduction ...

journal_title：Epilepsia

authors： Prichard JW

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ). METHODS:The 120 Wistar male rats were allocated randomly into four groups; (A) controls, and lead-treatment groups (B, C, and D) that received lead acetate ...

journal_title：Epilepsia

authors： Arrieta O,Palencia G,García-Arenas G,Morales-Espinosa D,Hernández-Pedro N,Sotelo J

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To evaluate prospectively patient's aims for epilepsy surgery as previously outlined theoretically by Taylor et al. (Epilepsia 1997;3:625-30). METHODS:Ninety-three consecutive patients were interviewed by a psychiatrist as part of their evaluation for epilepsy surgery. Open-ended questions about the patient we...

journal_title：Epilepsia

authors： Taylor DC,McMacKin D,Staunton H,Delanty N,Phillips J

更新日期：2001-05-01 00:00:00

abstract：:Dogs with spontaneous diseases can exhibit a striking similarity in etiology, clinical manifestation, and disease course when compared to human patients. Therefore, dogs are intensely discussed as a translational model of human disease. In particular, genetic studies in selected dog breeds serve as an excellent tool t...

journal_title：Epilepsia

authors： Potschka H,Fischer A,von Rüden EL,Hülsmeyer V,Baumgärtner W

更新日期：2013-04-01 00:00:00

abstract：:The pharmacokinetic profile of a newly developed Dilantin 300-mg Kapseal formulation was compared with that of currently marketed Dilantin 100-mg Kapseals in both a 300-mg single-dose bioequivalence study in nine healthy volunteers and a once-daily 300-mg multiple-dose study in 18 patients with seizures. Results of th...

journal_title：Epilepsia

authors： Randinitis EJ,Buchanan RA,Kinkel AW

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment. METHODS:Twelve patients with epilepsy stabilized on PHT monotherapy were enrolled in this st...

journal_title：Epilepsia

authors： Sachdeo RC,Sachdeo SK,Levy RH,Streeter AJ,Bishop FE,Kunze KL,Mather GG,Roskos LK,Shen DD,Thummel KE,Trager WF,Curtin CR,Doose DR,Gisclon LG,Bialer M

更新日期：2002-07-01 00:00:00

abstract：:We conducted a systematic review to determine which noninvasive technologies should be used in the workup for epilepsy surgery to identify structural or functional abnormalities to help locate the site of seizure onset. The review focused on patients where there was insufficient confidence, in either the decision to g...

journal_title：Epilepsia

authors： Burch J,Marson A,Beyer F,Soares M,Hinde S,Wieshmann U,Woolacott N

更新日期：2012-08-01 00:00:00

abstract：:Convulsive epilepsies are generally unmistakable. Absence epilepsies, which are easily recognized by the provocation of an episode during hyperventilation and by the typical features of the EEG, can be overdiagnosed, especially in the child who daydreams in class and has scattered, asymptomatic, epileptogenic EEG chan...

journal_title：Epilepsia

authors： Murphy JV,Dehkharghani F

更新日期：1994-01-01 00:00:00

abstract：:The teratological effect of nicotine has been studied during different trimesters of pregnancy. Three groups of pregnant albino Swiss mice were used for each trimester. The daily doses of nicotine base used were equivalent to 10 (900 micrograms/kg), 20 (1,800 micrograms/kg), or 30 (2,700 micrograms/kg) cigarettes. The...

journal_title：Epilepsia

authors： Al-Hachim GM,Mahmoud FA

更新日期：1985-11-01 00:00:00

abstract：PURPOSE:To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP). METHODS:Male Wistar rats, stereotactically implanted in both ventral hip...

journal_title：Epilepsia

authors： Cuellar-Herrera M,Peña F,Alcantara-Gonzalez D,Neri-Bazan L,Rocha L

更新日期：2010-03-01 00:00:00

abstract：:Epilepsy-prone and epilepsy-resistant substrains were selectively bred from a strain of BALB/c mice; audiogenic-sensitive epilepsy-prone animals showed enhanced sensitivity to chemical convulsants. Treatment with pyridoxine (100 mg/L in drinking water) initiated at mating and continued throughout pregnancy and the lif...

journal_title：Epilepsia

authors： Dolina S,Peeling J,Sutherland G,Pillay N,Greenberg A

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complicat...

journal_title：Epilepsia

authors： Bruno E,Böttcher S,Biondi A,Epitashvili N,Manyakov NV,Lees S,Schulze-Bonhage A,Richardson MP,RADAR-CNS Consortium.

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustai...

journal_title：Epilepsia

authors： Taub KS,Kessler SK,Bergqvist AG

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Controversy persists about when EEG became a fundamental tool in the preoperative investigation for epilepsy surgery. We revisit Penfield's first use of invasive EEG monitoring, emphasizing its historical importance for the evolution of epilepsy surgery. METHODS:Patients' hospital charts and articles published...

journal_title：Epilepsia

authors： Almeida AN,Martinez V,Feindel W

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:The main objective of this research is the development of automated video processing and analysis procedures aimed at the recognition and characterization of the types of neonatal seizures. The long-term goal of this research is the integration of these computational procedures into the development of a stand-a...

journal_title：Epilepsia

authors： Karayiannis NB,Tao G,Xiong Y,Sami A,Varughese B,Frost JD Jr,Wise MS,Mizrahi EM

更新日期：2005-06-01 00:00:00

abstract：:Identical twins concordant for partial epilepsy, with onset at 8 and 11 years of age, are presented. Their course has been benign on anticonvulsant therapy. It is suggested that these cases of presumed genetic epilepsy support current concepts of cortical origin and genetic determinants in several subtypes of focal ep...

journal_title：Epilepsia

authors： Hurst R,Lenn NJ

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:The medical benefits of epilepsy surgery are well documented, but the psychosocial consequences of surgery have received less attention. This is especially true of the roles of expectations and satisfaction in postsurgery functioning. The present study was designed to examine the relationships between expectati...

journal_title：Epilepsia

authors： Wheelock I,Peterson C,Buchtel HA

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:To describe the epidemiology of somatic and psychiatric conditions in adults with epilepsy in the community and compare it to that of people without epilepsy. METHODS:A cross-sectional population-based study extracting data from the UK General Practice Research Database for the period 1995-1998. Age- and sex-s...

journal_title：Epilepsia

authors： Gaitatzis A,Carroll K,Majeed A,W Sander J

更新日期：2004-12-01 00:00:00

abstract：:Little is known about the effects of carbamazepine (CBZ) on sleep despite the relationship between sleep and epilepsy and the common clinical use of CBZ. As part of a larger study on sleep and interictal activity in kindled cats, we performed sleep recordings in 11 normal cats before and after acute administration of ...

journal_title：Epilepsia

authors： Gigli GL,Gotman J,Thomas ST

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:The objective was to systematically review studies that have focused on behavioral and emotional functioning before (baseline) and after (follow-up) pediatric epilepsy surgery. METHODS:The systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyse...

journal_title：Epilepsia

authors： Reilly C,Baldeweg T,Stewart N,Wadhwani S,Jones C,Helen Cross J,Heyman I

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Self-management challenges facing adults with epilepsy include limited understanding of the condition and treatment, associated psychosocial issues, and lack of community integration. Self-management interventions improve patients' medical, life role, and emotional management. Previous interventions, develope...

journal_title：Epilepsia

authors： Fraser RT,Johnson EK,Lashley S,Barber J,Chaytor N,Miller JW,Ciechanowski P,Temkin N,Caylor L

更新日期：2015-08-01 00:00:00