The epidemiology of the comorbidity of epilepsy in the general population.

abstract：:From the earliest days of neurology, the classification of epileptic seizures into those generalized from the beginning and those with a definable localization in the cortex from the onset has added to knowledge about the function of the nervous system. Further elaboration of the classification of seizures into those ...

journal_title：Epilepsia

authors： Dreifuss FE

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Epilepsy is a nervous system abnormality that may be caused by unknown exposures during fetal development. Studies have shown neuroprotective effects of early exposure to vitamin D in other neurological disorders, and seasonal variation in birth of children with epilepsy. We aimed to investigate if neonatal 2...

journal_title：Epilepsia

authors： Specht IO,Thorsteinsdottir F,Walker KC,Olsen J,Heitmann BL

更新日期：2020-06-01 00:00:00

abstract：:1-Phenylcyclohexylamine (PCA) and its analogues 1-phenylcyclopentylamine (PPA) and 1-(3-fluorophenyl)cyclohexylamine (3-F-PCA) are potent anticonvulsants in the mouse maximal electroshock (MES) seizure test. Unlike the structurally related dissociative anesthetic phencyclidine (PCP), however, which produces motor toxi...

journal_title：Epilepsia

authors： Blake PA,Yamaguchi S,Thurkauf A,Rogawski MA

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To describe the semiologic features of aggressive behaviors observed in human epileptic seizures with particular reference to the act of biting a conspecific. METHODS:We analyzed the biting behavior (BB) and other aggressive gestures occurring in a group of 11 patients retrospectively selected from >1,000 pati...

journal_title：Epilepsia

authors： Tassinari CA,Tassi L,Calandra-Buonaura G,Stanzani-Maserati M,Fini N,Pizza F,Sartori I,Michelucci R,Lo Russo G,Meletti S

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To characterize the epileptogenic zone in neocortical epilepsy (NE) by using magnetoencephalography (MEG). METHODS:We defined and compared locations of single and multiple clusters of equivalent current dipoles (ECDs) for interictal spikes with MRI findings, ictal-onset zones (IOZs) from subdural electroenceph...

journal_title：Epilepsia

authors： Oishi M,Kameyama S,Masuda H,Tohyama J,Kanazawa O,Sasagawa M,Otsubo H

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Hypothalamic regulation of the reproductive axis in temporal lobe epilepsy (TLE), represented by the ultradian pulsatile secretion of luteinizing hormone (LH), has been shown to be altered interictally and postictally. Our objective is to determine if epilepsy or seizures disrupt normal circadian fluctuations o...

journal_title：Epilepsia

authors： Quigg M,Kiely JM,Johnson ML,Straume M,Bertram EH,Evans WS

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. A substantial number of past studies examined factors that predict memory decline after surger...

journal_title：Epilepsia

authors： Lineweaver TT,Morris HH,Naugle RI,Najm IM,Diehl B,Bingaman W

更新日期：2006-11-01 00:00:00

abstract：:Dipropylacetic acid (VPA, valproic acid) has been quantified in plasma and semen from rabbits and man using a new gas-liquid chromatographic assay. The drug assay is rapid, sensitive and free from interference by VPA metabolites. The beta phase half-life of VPA in rabbits after an i.v. dose (50 mg/kg) was 56 +/- 6 min...

journal_title：Epilepsia

authors： Swanson BN,Harland RC,Dickinson RG,Gerber N

更新日期：1978-12-01 00:00:00

abstract：:Some investigators argue that treating epilepsy with several antiepileptic drugs (AEDs) simultaneously (polytherapy) may give rise to more adverse effects than monotherapy, but this argument lacks supporting quantitative data. To reexamine this issue, we recruited a cohort of patients from the outpatients of the Speci...

journal_title：Epilepsia

authors： Lammers MW,Hekster YA,Keyser A,Meinardi H,Renier WO,van Lier H

更新日期：1995-05-01 00:00:00

abstract：:Status epilepticus (SE) is the most extreme form of epilepsy. It describes a prolonged seizure that may occur in patients with previous epilepsy or in acute disorders of the central nervous system. It is one of the most common neurologic emergencies, with an incidence of up to 41 per 100,000 per year and an estimated ...

journal_title：Epilepsia

authors： Trinka E,Höfler J,Zerbs A

更新日期：2012-09-01 00:00:00

abstract：:Seizures in the neonate are often considered a form of status epilepticus (SE) because they are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be associated with significant morbidity and mortality. Despite their clinical importance, there is still no clear understanding of how sei...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Accurate classification of epileptic seizures, epilepsies, and epilepsy syndromes is mandatory in both clinical practice and epilepsy research. In 2010, the International League Against Epilepsy (ILAE) proposed a new classification scheme. The aim of this study is to determine whether application of this new cl...

journal_title：Epilepsia

authors： van Campen JS,Jansen FE,Brouwer OF,Nicolai J,Braun KP

更新日期：2013-04-01 00:00:00

abstract：:Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X-linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Although medically refractory epilepsy often brings attention to...

journal_title：Epilepsia

authors： Montier L,Haneef Z,Gavvala J,Yoshor D,North R,Verla T,Van Ness PC,Drabek J,Goldman AM

更新日期：2019-10-01 00:00:00

abstract：:The effect od dipropylacetic acid (DPA; Depakine) on the bemegride-induced convulsive threshold was investigated in alert cats. Forty-five min after DPA 200 mg/kg, s.c., no significant effect was obtained; 5 min after the same dose iv., protection from bemegride-induced seizures was pronounced. DPA did not decrease fo...

journal_title：Epilepsia

authors： van Duijn H,Beckmann MK

更新日期：1975-03-01 00:00:00

abstract：PURPOSE:We review what is currently known about functional and morphologic plasticity of hippocampal neuronal circuits in animal epilepsy models. RESULTS:Perforant-path kindling has been shown to enhance excitatory synaptic transmission in the dentate gyrus significantly, and this enhancement has lasted for > or =1 mo...

journal_title：Epilepsia

authors： Maru E,Kanda M,Ashida H

更新日期：2002-01-01 00:00:00

abstract：:A double-blind, randomized, cross-over study of additional vigabatrin (gamma-vinyl-GABA, VGB, 1.0 g twice daily for 6 weeks, followed by 1.5 g twice daily for 6 weeks) and matched placebo was undertaken in 24 patients with refractory epilepsy. Nineteen completed the trial satisfactorily. Fewer seizure days were report...

journal_title：Epilepsia

authors： McKee PJ,Blacklaw J,Friel E,Thompson GG,Gillham RA,Brodie MJ

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

journal_title：Epilepsia

authors： Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To validate and translate the English version of the Neurologic Depression Disorders Inventory in Epilepsy (NDDI-E) into Spanish as a screening instrument for major depressive episodes (MDE) for patients with epilepsy from Argentina and Uruguay. METHODS:One hundred fifty-five consecutive outpatients with ep...

journal_title：Epilepsia

authors： Thomson AE,Calle A,Fontela ME,Yepez L,Muñoz Giacomelli F,Jáuregui A,Racosta JM,Kanner AM

更新日期：2014-02-01 00:00:00

abstract：:[3H]Nimodipine and high-affinity [125I]omega-conotoxin GVIA (CgTX) binding were investigated in membranes from rat cerebral cortex, cerebellum, and hippocampus after electrically and chemically induced seizures. Animals were decapitated 30 min after a single electroconvulsive shock (ECS) or lidocaine-induced seizure a...

journal_title：Epilepsia

authors： Gleiter CH,Cain CJ,Weiss SR,Post RM,Marangos PJ

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...

journal_title：Epilepsia

authors： Glauser TA,Miles MV,Tang P,Clark P,McGee K,Doose DR

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To assess medical intractability in patients considered for restrictive epilepsy surgery. METHODS:Seventy-four patients received single drug treatment with carbamazepine (CBZ), phenytoin (PHT), and either phenobarbital (PB) or primidone (PRM). Medical intractability was established if seizure control was not o...

journal_title：Epilepsia

authors： Hermanns G,Noachtar S,Tuxhorn I,Holthausen H,Ebner A,Wolf P

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:The antiepileptic drug (AED) vigabatrin (VGB), which exerts its pharmacologic effects on the gamma-aminobutyric acid (GABA) system, causes concentric visual field constriction in >40% of exposed adults. This may be a class effect of all agents with GABA-related mechanisms of action. We compared the concentratio...

journal_title：Epilepsia

authors： Sills GJ,Butler E,Forrest G,Ratnaraj N,Patsalos PN,Brodie MJ

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Intracerebral vascular malformations including cavernous angiomas (CAs) and arteriovenous malformations (AVMs) are an important cause of chronic pharmacoresistant epilepsies. Little is known about the pathogenetic basis of epilepsy in patients with vascular malformations. Intracerebral deposits of iron-containi...

journal_title：Epilepsia

authors： Raabe A,Schmitz AK,Pernhorst K,Grote A,von der Brelie C,Urbach H,Friedman A,Becker AJ,Elger CE,Niehusmann P

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...

journal_title：Epilepsia

authors： Leonhardt G,de Greiff A,Weber J,Ludwig T,Wiedemayer H,Forsting M,Hufnagel A

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Presurgical language mapping in dominant hemisphere epilepsy to evaluate the risk of postoperative deficit is particularly difficult in children. Extraoperative invasive cortical stimulation can show some areas critical to language, but not all of them, due to scarce sampling, poor cooperation, cortical immatur...

journal_title：Epilepsia

authors： de Ribaupierre S,Fohlen M,Bulteau C,Dorfmüller G,Delalande O,Dulac O,Chiron C,Hertz-Pannier L

更新日期：2012-01-01 00:00:00

abstract：:The use of rescue benzodiazepines in the management of seizures is widely accepted in emergency pediatric practice. They can, however, cause severe side effects, such as respiratory depression. We describe five patients who presented with severe respiratory depression following benzodiazepine administration for seizur...

journal_title：Epilepsia

authors： Lacroix L,Fluss J,Gervaix A,Korff CM

更新日期：2011-10-01 00:00:00

abstract：:The clinical presentation of 366 children with rolandic spikes was examined to determine whether the presence of a temporal-frontal dipole field is associated with a lower incidence of clinical abnormality. Comparisons were made between the clinical presentation of 99 children with temporal-frontal dipole discharges v...

journal_title：Epilepsia

authors： Gregory DL,Wong PK

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Studies have found that affected individuals who believe the cause of their disorder is genetic may react in various ways, including optimism for improved treatments and pessimism due to perceived permanence of the condition. This study assessed the psychosocial impact of genetic attribution among people with...

journal_title：Epilepsia

authors： Garofalo DC,Sorge ST,Hesdorffer DC,Winawer MR,Phelan JC,Chung WK,Ottman R

更新日期：2019-11-01 00:00:00

abstract：:In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

journal_title：Epilepsia

authors： McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

更新日期：2020-08-01 00:00:00

abstract：:In a double-blind, randomized, parallel-group trial, we compared topiramate (TPM) with placebo as add-on therapy in patients with refractory partial epilepsy. TPM was titrated either to the target dosage of 800 mg/ day [400 mg twice daily (b.i.d)] or to the maximal tolerated dose if lower. Twenty-eight (28) patients w...

journal_title：Epilepsia

authors： Ben-Menachem E,Henriksen O,Dam M,Mikkelsen M,Schmidt D,Reid S,Reife R,Kramer L,Pledger G,Karim R

更新日期：1996-06-01 00:00:00