A procedure for developing a quality-of-life measure for epilepsy surgery patients.

abstract：OBJECTIVE:To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. METHODS:We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analys...

journal_title：Epilepsia

authors： Loesch AM,Steger H,Losher C,Hartl E,Rémi J,Vollmar C,Noachtar S

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...

journal_title：Epilepsia

authors： Eisermann MM,Ville D,Soufflet C,Plouin P,Chiron C,Dulac O,Kaminska A

更新日期：2006-06-01 00:00:00

abstract：:All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...

journal_title：Epilepsia

authors： McAreavey MJ,Ballinger BR,Fenton GW

更新日期：1992-07-01 00:00:00

abstract：:Little is known about what factors predict intractable epilepsy at the time of initial diagnosis. We performed a case-control study to identify early predictors of medically intractable epilepsy in children. Cases were children who had an average of one seizure or more a month over a 2-year period and who, during that...

journal_title：Epilepsia

authors： Berg AT,Levy SR,Novotny EJ,Shinnar S

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：:The clinical identification of neonatal seizures is critical for the recognition of brain dysfunction; however, diagnosis is often difficult because of the poorly organized and varied nature of these behaviors. Current classification systems are limited in their ability to communicate motor, autonomic, and electroence...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1987-01-01 00:00:00

abstract：:Nonconvulsive status epilepticus may be subdivided into generalized (absence) status and complex partial status. The latter is regarded as a rarity, whereas the former constitutes the dominant part of the hitherto reported cases. We report 10 consecutive cases of adult patients with nonconvulsive status epilepticus, a...

journal_title：Epilepsia

authors： Tomson T,Svanborg E,Wedlund JE

更新日期：1986-05-01 00:00:00

abstract：:Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volu...

journal_title：Epilepsia

authors： Faught E

更新日期：2001-01-01 00:00:00

abstract：:There is little evidence to guide the choice of intravenous anesthetic agent to treat refractory status epilepticus but midazolam, propofol, and barbiturates are widely used. It is impractical to use inhalational anesthetic agents in most circumstances and there is little experience with non-GABA-ergic agents such as ...

journal_title：Epilepsia

authors： Smith M

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To investigate the effects of nitric oxide (NO) on seizure activity observed in brain areas that are remote from a primary epileptic focus. METHODS:Following an injection of kainate (concentration 1 mg/ml, volume 1 microl) in the rat hippocampus, we measured NO synthesis in the contralateral hippocampus and ep...

journal_title：Epilepsia

authors： Yasuda H,Fujii M,Fujisawa H,Ito H,Suzuki M

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:This study investigated the functional plasticity of the brain to reconstitute and compensate for verbal memory functions after epilepsy surgery of left temporocortical and temporomesial structures. We hypothesized that memory outcome would be best when surgery is performed within the period of cerebral plastic...

journal_title：Epilepsia

authors： Helmstaedter C,Elger CE

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To identify the timelines of magnetic resonance imaging (MRI) abnormalities and their relationships with the clinical outcomes of patients with new-onset refractory status epilepticus (NORSE). METHODS:This retrospective observational study enrolled patients with NORSE who were admitted from March 2008 to Jul...

journal_title：Epilepsia

authors： Kim HJ,Lee SA,Kim HW,Kim SJ,Jeon SB,Koo YS

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:The posterior cingulate cortex (PCC)/precuneus is a key hub of the default mode network, whose function is known to be altered in epilepsy. Glutamate and γ-aminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters in the central nervous system, respectively. Glutathione (GSH) is the mo...

journal_title：Epilepsia

authors： Gonen OM,Moffat BA,Desmond PM,Lui E,Kwan P,O'Brien TJ

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Knowledge, attitudes, and perceptions of epilepsy (KAPE) among the public play a major role in determining the extent to which people with epilepsy can be integrated into their society. KAPE SURVEYS IN ASIA:Surveys conducted among Chinese in China, Taiwan, Malaysia, Singapore, and Hong Kong demonstrated simila...

journal_title：Epilepsia

authors： Lim SH,Pan A

更新日期：2005-01-01 00:00:00

abstract：:We report 10 seizure-related thermal injuries severe enough to require hospitalization in patients with epilepsy. Eight of the ten incidents were with patients who had had seizures with impaired consciousness two or more times a month. This suggests that seizure frequency is a risk factor and implies the importance of...

journal_title：Epilepsia

authors： Spitz MC

更新日期：1992-01-01 00:00:00

abstract：:In 45 patients suffering from secondary generalized epilepsy, we have recorded 239 drop seizures both by radio-telemetered EEG/split-screen video taping and polygraphically. Twenty of these patients had pure tonic drop seizures. Nine patients each had myoclonic-atonic or pure atonic seizures, whereas seven had slow fa...

journal_title：Epilepsia

authors： Egli M,Mothersill I,O'Kane M,O'Kane F

更新日期：1985-09-01 00:00:00

abstract：:The first description of epileptic encephalopathies dates back to Dr. West who, in 1857, described the syndrome that took his name. In addition to West syndrome, in the last century other epileptic syndromes entered into the chapter of epileptic encephalopathies. Henry Gastaut has the virtue of having created the mode...

journal_title：Epilepsia

authors： Capovilla G,Wolf P,Beccaria F,Avanzini G

更新日期：2013-11-01 00:00:00

abstract：:The possibility of sudden unexpected death in epilepsy (SUDEP) should affect the management of virtually every patient with proven or suspected epilepsy by (a) underlining the need to make all reasonable efforts to render each patient seizure-free; (b) emphasizing the importance of minimizing avoidable seizures; (c) b...

journal_title：Epilepsia

authors： Fish DR

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:It remains controversial whether a specific pattern of interictal epileptiform activity exists that may help to differentiate temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) from other forms of TLE. In this study, we characterized the distribution of interictal epileptiform discharges in TLE due ...

journal_title：Epilepsia

authors： Hamer HM,Najm I,Mohamed A,Wyllie E

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:In the last decade several studies have been published on incidence, etiology, and prognosis of status epilepticus (SE) with population-based data from the United States and Europe. The aim of this review is to summarize the available information on the epidemiology of SE and to outline the sources of the var...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC,Cascino G,Hauser WA,Coeytaux A,Galobardes B,Morabia A,Jallon P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To study the course and outcome of childhood-onset epilepsy during 15-year follow-up (FU). METHODS:We extended FU in 413 of 494 children with new-onset epilepsy recruited in a previously described prospective hospital-based study by questionnaire. RESULTS:Mean FU was 14.8 years (range 11.6-17.5 years). Five-y...

journal_title：Epilepsia

authors： Geerts A,Arts WF,Stroink H,Peeters E,Brouwer O,Peters B,Laan L,van Donselaar C

更新日期：2010-07-01 00:00:00

abstract：:Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...

journal_title：Epilepsia

authors： Rodin EA,Katz M,Lennox K

更新日期：1976-09-01 00:00:00

abstract：PURPOSE:Our aim was to develop a screening test to predict Dravet syndrome before the first birthday based on the clinical characteristics of infants and the SCN1A mutation analysis. METHODS:Ninety-six patients who experienced febrile seizures before the age of one were enrolled. The patients were divided into two gro...

journal_title：Epilepsia

authors： Hattori J,Ouchida M,Ono J,Miyake S,Maniwa S,Mimaki N,Ohtsuka Y,Ohmori I

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:Zinc is released in synaptic vesicles with glutamate, and modulates glutamatergic neurotransmission. In brain, the highest amount of zinc, detected by Timm staining, is in the mossy fiber (MF) system in the hippocampus. In the intrahippocampal kainate (KA) mouse model of mesial temporal lobe epilepsy, which is ...

journal_title：Epilepsia

authors： Mitsuya K,Nitta N,Suzuki F

更新日期：2009-08-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of lamotrigine (LTG), a new antiepileptic drug (AED), were studied in healthy volunteers. In an open dose-escalating study, LTG 240 mg produced peak plasma concentrations of around 3 micrograms/mg with no significant adverse events. Subsequent pharmacokinetic studies revealed ...

journal_title：Epilepsia

authors： Peck AW

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:A pilot study of the safety, tolerability, dose range and potential efficacy of ganaxolone for the treatment of refractory epilepsy in pediatric and adolescent subjects. METHODS:We report the results of a nonrandomized, nonblinded, open-label, dose-escalation trial of ganaxolone in pediatric subjects (5-15 yea...

journal_title：Epilepsia

authors： Pieribone VA,Tsai J,Soufflet C,Rey E,Shaw K,Giller E,Dulac O

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To explore the structure-function relation of the temporal lobe in newly diagnosed West syndrome of unknown cause (uWS). METHODS:Quantitative magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and tract-based ...

journal_title：Epilepsia

authors： Fosi T,Chu C,Chong WK,Clark C,Scott RC,Boyd S,De Haan M,Neville B

更新日期：2015-04-01 00:00:00

abstract：:Of the 605 patients seen since 1973, 336 patients have been treated with sodium valproate (VPA) alone or in combination with drugs other than carbamazepine (CBZ). Of these 336, 240 have been on monotherapy, of whom 200 are seizure-free. Follow up has been longer than 3 years in 78%. Complete control of seizures has be...

journal_title：Epilepsia

authors： Covanis A,Gupta AK,Jeavons PM

更新日期：1982-12-01 00:00:00

abstract：PURPOSE:To study the neuropsychological status of an epileptic patient presenting with epileptic activity triggered by eye closure in a 14-year follow-up period. METHODS:The patient was studied at 12 and 26 years of age; during this period he underwent periodical clinical evaluations and EEG investigations; brain magn...

journal_title：Epilepsia

authors： Termine C,Rubboli G,Veggiotti P

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Hippocampal sclerosis (HS) is the most common pathologic finding in intractable temporal lobe epilepsy (TLE). In many patients, HS is accompanied by an extrahippocampal lesion (EHL). We sought to assess the lobar distribution and side of EHLs in relation to HS in a large consecutive series of patients presentin...

journal_title：Epilepsia

authors： Hofman PA,Fitt G,Mitchell LA,Jackson GD

更新日期：2011-04-01 00:00:00